Cited by 362Cardiac electrophysiology and arrhythmiasAcute Myocardial Infarction ResearchECG Monitoring and Analysis

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Fragmented Wide QRS on a 12-Lead ECG: A Sign of Myocardial Scar and Poor Prognosis

Das, Mithilesh K., Suradi, Hussam, Maskoun, Waddah, Michael, Mark A., Shen, Changyu, Peng, Jonathan, Dandamudi, Gopi, Mahenthiran, Jo·2008·Circulation: Arrhythmia and Electrophysiology

DOI 10.1161/circep.107.763284

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Abstract

Background— Fragmented QRS (duration <120 ms) on a 12-lead ECG represents myocardial scar in patients with coronary artery disease. However, the significance of fragmented QRS has not been defined in the presence of a wide QRS (wQRS; duration ≥120 ms). We postulate that fragmented wQRS (f-wQRS) due to bundle branch block, premature ventricular complexes, or paced rhythms (f-pQRS) signify myocardial scar and higher mortality. Methods and Results— Patients who underwent cardiac evaluation with nuclear stress imaging or cardiac catheterization and had wQRS (bundle branch block, premature ventricular complex, or pQRS) were studied. f-wQRS was defined by the presence of >2 notches on the R wave or the S wave and had to be present in ≥2 contiguous inferior (II, III, aVF), lateral (I, aVL, V 6 ) or anterior (V 1 to V 5 ) leads. ECG analyses of 879 patients (age, 66.7�11.4 years; male, 97%; mean follow-up, 29�18 months) with bundle branch block (n=310), premature ventricular complex (n=301), and pQRS (n=268) revealed f-wQRS in 415 (47.2%) patients. Myocardial scar was present in 440 (50%) patients. The sensitivity, specificity, positive predictive value, and negative predictive value of f-wQRS for myocardial scar were 86.8%, 92.5%, 92.0%, and 87.5%, respectively. The sensitivity and specificity for diagnosing myocardial scar were 88.6% and 94.4%, 81.4% and 88.4%, and 89.8% and 95.7% for f-bundle branch block, f-premature ventricular complex, and f-pQRS, respectively. f-wQRS was associated with mortality after adjusting for age, ejection fraction, and diabetes ( P =0.017). Conclusions— f-wQRS on a standard 12-lead ECG is a moderately sensitive and highly specific sign for myocardial scar in patients with known or suspected coronary artery disease. f-wQRS is also an independent predictor of mortality.

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Time course for reversal of electrophysiological and ultrastructural abnormalities in subendocardial Purkinje fibers surviving extensive myocardial infarction in dogs.
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Freedman, R. A., Alderman, E. L., Sheffield, L. T., Saporito, M. S., & Fisher, L. D. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80162-6 · Cited by 182
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Show all 35 references

Research works printed but not linked: 8

10.1161/circ.37.1.20 · DOI
10.1161/circ.81.4.1690614 · DOI
10.1161/circ.105.4.539 · DOI
10.1161/res.36.1.1116215 · DOI
10.1161/circ.91.5.1480 · DOI
10.1161/circ.40.6.927 · DOI
10.1161/circ.65.3.6459890 · DOI
Maskoun W, Suradi H, Mahenthiran J, Bhakta D, Das M. Fragmented QRS complexes on a 12-lead ECG predict arrhythmic events in patients with ischemic cardiomyopathy who receive an ICD for primary prophylaxis. Heart Rhythm. 2007; 4: S211–S212.

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Erdem, F., Tavıl, Y., Yazıcı, H., Aygül, N., Abacı, A., & Boyacı, B. (2012) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12011 · Cited by 25
12-Lead Electrocardiogram to Localize Region of Abnormal Electroanatomic Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy
Tschabrunn, C. M., Haqqani, H. M., Santangeli, P., Zado, E. S., & Marchlinski, F. E. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.01.009 · Cited by 25
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Cardiac diagnoses and long-term outcomes in ring-like late gadolinium enhancement evaluated by cardiac magnetic resonance
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The relationship between fragmentation on electrocardiography and in-hospital prognosis of patients with acute myocardial infarction
Erdinler, I. C. (2014) · Medical Science Monitor · doi:10.12659/msm.890201 · Cited by 23
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Claridge, S., Mennuni, S., Jackson, T., Behar, J. M., Porter, B., Sieniewicz, B., Bostock, J., O'Neill, M. D., MURGATROYD, F. D., Gill, J. S., et al. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13226 · Cited by 23
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Ahn, M., Kim, J., Yoo, B., Lee, J., Lee, J. H., Youn, Y. J., Ahn, S. G., Kim, J.-Y., Lee, S., Yoon, J., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.12.086 · Cited by 22
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Çelikyurt, U., Ağaçdiken, A., Şahı̇n, T., Al, N. Ö., Vural, A., & Ural, D. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9715-0 · Cited by 21
Predictive value of fragmented QRS in primary prevention implantable cardioverter defibrillator recipients with left ventricular dysfunction
Forleo, G. B., Rocca, D. G. D., Papavasileiou, L. P., Panattoni, G., Sergi, D., Duro, L., Mahfouz, K., Magliano, G., Santini, L., & Romeo, F. (2011) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32834ae458 · Cited by 21
Inter- and intra-observer variability of visual fragmented QRS scoring in ischemic and non-ischemic cardiomyopathy
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Predictive value of the fragmented QRS complex in 6-month mortality and morbidity following acute coronary syndrome
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Park, C. H., Chung, H., Kim, Y., Kim, J., Min, P., Lee, K., Yoon, Y. W., Kim, T. H., Lee, B. K., Hong, B., et al. (2018) · International journal of cardiac imaging · doi:10.1007/s10554-018-1365-6 · Cited by 20
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Kurtul, A., & Duran, M. (2017) · Clinical Cardiology · doi:10.1002/clc.22651 · Cited by 20
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Özcan, F., Turak, O., Canpolat, U., Avci, S., Tok, D., İşleyen, A., Cebeci, M., Yüzgeçer, H., Gurel, O. M., Topaloğlu, S., et al. (2014) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12141 · Cited by 19
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Hayashi, T., Fukamizu, S., Hojo, R., Komiyama, K., Tanabe, Y., Tejima, T., Nishizaki, M., Hiraoka, M., Ako, J., Momomura, S., et al. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0335 · Cited by 19
The independent relationship between systemic inflammation and fragmented QRS complexes in patients with stable angina pectoris.
Çetın, M., Kocaman, S. A., Çanğa, A., Durakoğlugil, M. E., Erdoğan, T., Şatıroğlu, Ö., Kırış, T., Uğurlu, Y., Çiçek, Y., & Bostan, M. (2012) · PubMed · Cited by 19
Significance of a fragmented QRS complex in patients with chronic total occlusion of coronary artery without prior myocardial infarction
Bonakdar, H. R., Moladoust, H., Kheirkhah, J., Abbaspour, E., Rad, M. A., Salari, A., Barzigar, A., & Shad, B. M. (2015) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2015.5887 · Cited by 19
Fragmented QRS may predict postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass graft surgery
Çetın, M., Kocaman, S. A., Erdoğan, T., Durakoğlugil, M. E., Çiçek, Y., Bozok, Ş., Çanğa, A., Temız, A., Doğan, S., & Şatıroğlu, Ö. (2012) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2012.184 · Cited by 19
The Independent Relationship of Systemic Inflammation With Fragmented QRS Complexes in Patients With Acute Coronary Syndromes
Çetın, M., Kocaman, S. A., Erdoğan, T., Çanğa, A., Durakoğlugil, M. E., Şatıroğlu, Ö., Akgül, Ö., Kırış, T., Çiçek, Y., Yaylak, B., et al. (2012) · Korean Circulation Journal · doi:10.4070/kcj.2012.42.7.449 · Cited by 19
Myocardial Tissue Perfusion Predicts the Evolution of Fragmented QRS in Patients with ST‐Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Özcan, F., Turak, O., Canpolat, U., Kadife, İ., Avci, S., İşleyen, A., Cebeci, M., Gurel, O. M., Başar, F. N., Tok, D., et al. (2014) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12146 · Cited by 18
Relationship between fragmented QRS complexes and left ventricular systolic and diastolic functions
Çanğa, A., Kocaman, S. A., Durakoğlugil, M. E., Çetın, M., Erdoğan, T., Kırış, T., & Erden, M. (2013) · Herz · doi:10.1007/s00059-012-3739-1 · Cited by 18
Prognostic significance of fragmented QRS in patients with non-ST elevation myocardial infarction
Guo, R., Zhang, J., Li, Y., Xu, Y., Tang, K., & Li, W. (2012) · Herz · doi:10.1007/s00059-012-3603-3 · Cited by 18
Appearance of QRS fragmentation late after Mustard/Senning repair is associated with adverse outcome
Helsen, F., Vandenberk, B., Meester, P. D., Bruaene, A. V. D., Gabriels, C., Troost, E., Gewillig, M. H. M. L., Meyns, B. P., Willems, R., & Budts, W. (2017) · Heart · doi:10.1136/heartjnl-2016-310512 · Cited by 18
Fragmented QRS Can Predict Severity of Aortic Stenosis
Açıkgöz, E., Yaman, B., Açi̇kgöz, S. K., Topal, S., Tavıl, Y., & Boyacı, N. B. (2014) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12175 · Cited by 18
Fragmented QRS Complexes—A Novel but Underutilized Electrocardiograhic Marker of Heart Disease
Fares, H., Heist, E. K., Lavie, C. J., Kumbala, D. R., Ventura, H. O., Meadows, R. Y., Carter, W., Deitelzweig, S. B., & Basu‐Ray, I. (2013) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0b013e31829e005d · Cited by 18
Notched QRS for the Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy
Kawasaki, T., Harimoto, K., Honda, S., Sato, Y., Yamano, M., Miki, S., & Kamitani, T. (2015) · Circulation Journal · doi:10.1253/circj.cj-14-1109 · Cited by 18
A machine learning algorithm for electrocardiographic fQRS quantification validated on multi-center data
Villa, A., Vandenberk, B., Kenttä, T. V., Ingelaere, S., Huikuri, H. V., Zabel, M., Friede, T., Sticherling, C., Tuinenburg, A. E., Malík, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10452-0 · Cited by 17
Fragmented Surface ECG Was a Poor Predictor of Appropriate Therapies in Patients with Chagas’ Cardiomyopathy and ICD Implantation (Fragmented ECG in CHAgas’ Cardiomyopathy Study)
Baranchuk, A. M., Femenía, F., Diez, J. C. L., Muratore, C. A., Valentino, M., Retyk, E., Galizio, N. O., Toro, D. D., Alonso, K., Hopman, W. M., et al. (2013) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12077 · Cited by 17
The delayed activation wave in non-ST-elevation myocardial infarction
Niu, T., Fu, P., Jia, C., Dong, Y., Liang, C., Cao, Q., Yang, Z., Fu, R., Zhang, X., & Sun, Z. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.05.063 · Cited by 17

Authors: Das, M. K., Suradi, H., Maskoun, W., Michael, M. A., Shen, C., Peng, J., Dandamudi, G., & Mahenthiran, J.
Affiliations: Indiana University Indianapolis (US)
ORCID: Das, Mithilesh K.
Suradi, Hussam
Maskoun, Waddah
Shen, Changyu
Venue: Circulation: Arrhythmia and Electrophysiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-10
Volume: 1
Issue: 4
Pages: 258-268
ISSN: 1941-3084 (ISSN-L)
1941-3149
DOI: 10.1161/circep.107.763284
OpenAlex: W2107103201
Cited by: 362
References: 35
Citations by year: 2026: 12 · 2025: 16 · 2024: 21 · 2023: 7 · 2022: 20 · 2021: 26 · 2020: 24 · 2019: 32 · 2018: 20 · 2017: 24 · 2016: 19 · 2015: 27 · 2014: 38 · 2013: 20 · 2012: 31
FWCI: 6.09
Type: journal article
Language: en
Open access: closed
Locations: Circulation Arrhythmia and Electrophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
Keywords: fragmented QRS complex, wide QRS, myocardial scar, coronary artery disease, bundle branch block, premature ventricular contractions, paced rhythm, mortality prediction, 12-lead ECG, electrocardiographic markers
MeSH terms: Aged, Bundle-Branch Block, Cicatrix, Coronary Artery Disease, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Myocardium, Prognosis, Retrospective Studies, Time Factors, Reproducibility of Results, Tomography, Emission-Computed, Single-Photon, Ventricular Premature Complexes

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Fragmented Wide QRS on a 12-Lead ECG: A Sign of Myocardial Scar and Poor Prognosis

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