Cited by 847Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

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Treatment of Atrial Fibrillation With Antiarrhythmic Drugs or Radiofrequency Ablation: Two Systematic Literature Reviews and Meta-Analyses

Calkins, Hugh, Reynolds, Matthew R., Spector, Peter, Sondhi, Manu, Xu, Yingxin, Martin, Amber, Williams, Catherine J., Sledge, Isabella·2009·Circulation Arrhythmia and Electrophysiology

DOI 10.1161/circep.108.824789

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Abstract

BACKGROUND: Although radiofrequency catheter ablation (RFA) has evolved from an experimental procedure to an important treatment option for atrial fibrillation, the relative safety and efficacy of catheter ablation relative to that of antiarrhythmic drug (AAD) therapy has not been established. METHODS AND RESULTS: Two separate systematic reviews were conducted: one on RFA and the other on AAD to provide accurate and broadly representative estimates of the clinical efficacy and safety of both therapies in the treatment of atrial fibrillation. Electronic searches were conducted in EMBASE and MEDLINE from 1990 to 2007. For the RFA review, all study designs were accepted. For the AAD review, articles were limited to prospective studies on the following drugs of interest: amiodarone, dofetilide, sotalol, flecainide, and propafenone. Data were extracted by 1 reviewer, with a second reviewer performing independent confirmation of extracted data. Sixty-three RFA and 34 AAD studies were included in the reviews. Patients enrolled in RFA studies tended to be younger (mean age, 55 versus 62 years), had longer duration of atrial fibrillation (6.0 versus 3.1 years), and had failed a greater number of prior drug trials (2.6 versus 1.7). The single-procedure success rate of ablation off AAD therapy was 57% (95% CI, 50% to 64%), the multiple procedure success rate off AAD was 71% (95% CI, 65% to 77%), and the multiple procedure success rate on AAD or with unknown AAD usage was 77% (95% CI, 73% to 81%). In comparison, the success rate for AAD therapy was 52% (95% CI, 47% to 57%). A major complication of catheter ablation occurred in 4.9% of patients. Adverse events for AAD studies, although more common (30% versus 5%), were less severe. CONCLUSIONS: Studies of RFA for treatment of atrial fibrillation report higher efficacy rates than do studies of AAD therapy and a lower rate of complications.

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10.1161/circ.98.23.2574 · DOI

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BackgroundResultInfluential
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“A previous meta‐analysis found that the single‐procedure success rate of PVI for all types of AF without antiarrhythmic drugs was 50% to 64%.(8) It follows that the rate of AF recurrence after successful PVI remains relatively high.”
Background
Safety of Lower Activated Clotting Times During Atrial Fibrillation Ablation Using Open Irrigated Tip Catheters and a Single Transseptal Puncture
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BackgroundMethodInfluential
Left atrial functional and structural changes associated with ablation of atrial fibrillation - Cardiac magnetic resonance study
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“incorporated the vast majority of patients with paroxysmal AF which is in line with success rates of pulmonary vein isolation in this population.(29) Notably, however, even persistent AF patients with LAECS < 4 cm were noninducible after pulmonary vein isolation, suggesting that isolation of PV triggers could be succe…”
Result
Comparative effectiveness of antiarrhythmic drugs for rhythm control of atrial fibrillation
Qin, D., Leef, G. C., Alam, M. B., Rattan, R., Munir, M. B., Patel, D. R., Khattak, F. H., ADELSTEIN, E. C., Jain, S. K., & Saba, S. (2015) · Journal of Cardiology · doi:10.1016/j.jjcc.2015.07.001 · Cited by 29
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Background
Catheter Ablation vs Lifestyle Modification With Antiarrhythmic Drugs to Treat Atrial Fibrillation
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“Major periprocedural complications were reported in 5% of patients treated using RF ablation (Calkins et al., 2009).”
Background
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Ferguson, C., Inglis, S. C., Newton, P. J., Middleton, S., Macdonald, P. S., & Davidson, P. M. (2013) · Australian Critical Care · doi:10.1016/j.aucc.2013.08.002 · Cited by 27
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Background
Atrio-Esophageal Fistula: A Case Series and Literature Review
Schuring, C. A., Mountjoy, L. J., Priaulx, A. B., Schneider, R. J., Smith, H. L., Wall, G. C., Kadaria, D., & Sodhi, A. (2017) · American Journal of Case Reports · doi:10.12659/ajcr.903966 · Cited by 28
Contiguity Between Ablation Lesions and Strict Catheter Stability Settings Assessed by VISITAGTM Module Improve Clinical Outcomes of Paroxysmal Atrial Fibrillation Ablation ― Results From the VISITALY Study ―
Zucchelli, G., Sirico, G., Rebellato, L., Marini, M., Stabile, G., Greco, M. D., Castro, A., Ruvo, E. D., Soldati, E., Zingarini, G., et al. (2018) · Circulation Journal · doi:10.1253/circj.cj-17-0421 · Cited by 26
“Exclusion criteria were: (1) persistent and permanent AF; (2) previous catheter ablation of AF; (3) New York Heart Association functional class >II; (4) left atrial diameter (LAd) >50 mm in the parasternal long-axis view; (5) unstable angina or acute myocardial infarction within 3 months; (6) need for or prior cardiac…”
BackgroundMethod
Impact of Atrial Fibrillation Ablation on Recurrent Hospitalization
Guo, J., Nayak, H. M., Besser, S. A., Beaser, A. D., Aziz, Z. A., Broman, M., Özcan, C., Tung, R. H., & Upadhyay, G. A. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.10.015 · Cited by 26
“nuscript received July 23, 2018; revised manuscript received September of pulmonary veins and other ectopic foci has become a mainstay treatment for drug-refractory symptomatic AF (5).”
Background
Can we improve outcomes in AF patients by early therapy?
Kirchhof, P. F. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-72 · Cited by 26
“rate in patients with paroxysmal AF compared to patients with sustained forms of the arrhythmia [31].”
Result
Quantitative evaluation of atrial radio frequency ablation using intracardiac shear‐wave elastography
Kwiecinski, W., Provost, J., Dubois, R., Sacher, F., Haı̈ssaguerre, M., Legros, M., Nguyen‐Dinh, A., Dufait, R., Tanter, M., & Pernot, M. (2014) · Medical Physics · doi:10.1118/1.4896820 · Cited by 25
Management of atrial fibrillation around the world: a comparison of current ACCF/AHA/HRS, CCS, and ESC guidelines
Wasmer, K., & Eckardt, L. (2011) · EP Europace · doi:10.1093/europace/eur172 · Cited by 25
Comparing the 2010 North American and European Atrial Fibrillation Guidelines
Gillis, A. M., & Skanes, A. C. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.009 · Cited by 25
Ablation of multi-wavelet re-entry: general principles and in silico analyses
Spector, P., de Sa, D. D. C., Tischler, E. S., Thompson, N. C., Habel, N., Stinnett-Donnelly, J. M., Benson, B. E., Bielau, P., & Bates, J. H. T. (2012) · EP Europace · doi:10.1093/europace/eus278 · Cited by 25
Association of P wave duration index with atrial fibrillation recurrence after cryoballoon catheter ablation
Kaypaklı, O., Koca, H., Şahin, D. Y., Okar, S., Karataş, F., & Koç, M. (2017) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2017.09.016 · Cited by 25
Efficacy and safety of high-power short-duration ablation for atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials
Amin, A. M., Ghaly, R., Ibrahim, A. A. A., Ali, M. A., Almaadawy, O., Elzahaby, A., Abuelazm, M. T., Abdelazeem, B., & Munir, M. B. (2024) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-024-01782-2 · Cited by 26
Cost-Effectiveness of Catheter Ablation for Rhythm Control of Atrial Fibrillation
Blackhouse, G., Assasi, N., Xie, F., Gaebel, K., Campbell, K., Healey, J. S., O’Reilly, D. J., & Goeree, R. A. (2013) · International Journal of Vascular Medicine · doi:10.1155/2013/262809 · Cited by 25
“The probability of AF ablation procedural complications was taken from a systematic review of RCT and non-RCT studies evaluating catheter-based AF ablation procedures [31].”
Method
First Dutch experience with the endoscopic laser balloon ablation system for the treatment of atrial fibrillation
Gal, P., Smit, J. J. J., Adıyaman, A., Misier, A. R. R., Delnoy, P. P. H. M., & Elvan, A. (2014) · Netherlands Heart Journal · doi:10.1007/s12471-014-0624-y · Cited by 24
“Pulmonary vein isolation (PVI) has become an important treatment modality for atrial fibrillation (AF) [1, 2] although AF recurrences can occur [3].”
BackgroundMethod
Characteristics and management of outpatients with history of or current atrial fibrillation: The observational French EPHA study
Cohen, A. A., Dallongeville, J., Durand‐Zaleski, I., Bouée, S., & Heuzey, J. L. (2010) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2010.06.001 · Cited by 24
Cardiac shear-wave elastography using a transesophageal transducer: application to the mapping of thermal lesions in ultrasound transesophageal cardiac ablation
Kwiecinski, W., Bessière, F., Constanciel, É., N’Djin, W. A., Tanter, M., Lafon, C., & Pernot, M. (2015) · Physics in Medicine and Biology · doi:10.1088/0031-9155/60/20/7829 · Cited by 24
Ablation procedures for rhythm control in patients with atrial fibrillation: clinical and cost-effectiveness analyses.
Assasi, N., Blackhouse, G., Xie, F. X., Gaebel, K., Robertson, D., Hopkins, R. B., Healey, J. S., Roy, D., & Goeree, R. A. (2012) · Europe PMC (PubMed Central) · Cited by 24
Epicardial and endocardial electrophysiological guided thoracoscopic surgery for atrial fibrillation: A multidisciplinary approach of atrial fibrillation ablation in challenging patients
Krul, S. P. J., Pison, L., Meir, M. L., Driessen, A. H. G., Wilde, A. A. M., Maessen, J. G., de Mol, B. A. J. M., Crijns, H. J. G. M., & de Groot, J. R. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.02.043 · Cited by 23
“Catheter-based pulmonary vein antrum isolation (PVAI) [2] is most effective in patients with paroxysmal AF [3,4] and normally sized left”
Background
Three-month lower-dose flecainide after catheter ablation of atrial fibrillation
Hayashi, M., Miyauchi, Y., Iwasaki, Y., Yodogawa, K., Tsuboi, I., Uetake, S., Hayashi, H., Takahashi, K., & Shimizu, W. (2014) · EP Europace · doi:10.1093/europace/euu041 · Cited by 23
PREvention of recurrent arrhythmias with Mediterranean diet (PREDIMAR) study in patients with atrial fibrillation: Rationale, design and methods
Barrio-López, M. T., Ruiz‐Canela, M., Ramos, P., Tercedor, L., Ibáñez, J. L., Ortiz, M., Goñi, L., Ibáñez-Críado, A., Ruiz, R. M., García‐Bolao, I., et al. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.10.009 · Cited by 23
Atrial Fibrillation: The Science behind Its Defiance
Czick, M. E., Shapter, C., & Silverman, D. I. (2016) · Aging and Disease · doi:10.14336/ad.2016.0211 · Cited by 26
“For nonsurgical AF candidates, intravascular catheter ablation is increasingly utilized, and meta-analyses have shown it to be more successful against AF than antiarrhythmic drugs [226, 227].”
Background
Management of Intraprocedural Anticoagulation in Patients on Non-Vitamin K Antagonist Oral Anticoagulants Undergoing Catheter Ablation for Atrial Fibrillation
Martin, A., Godiér, A., Narayanan, K., Smadja, D. M., & Marijon, É. (2018) · Circulation · doi:10.1161/circulationaha.117.033326 · Cited by 23
[Mechanism of the therapeutic action of whole mare's and camel's milk in chronic hepatitis].
Sharmanov, T. S., Zhangabylov, A. K., & Rd, Z. (1982) · PubMed · Cited by 23
Left atrial shape is independent predictor of arrhythmia recurrence after catheter ablation for atrial fibrillation: A shape statistics study
Jia, S., Nivet, H., Harrison, J., Pennec, X., Camaioni, C., Jaı̈s, P., Cochet, H., & Maxime Sermesant, B. (2021) · Heart Rhythm O2 · doi:10.1016/j.hroo.2021.10.013 · Cited by 22
“LA shape to predict AF recurrence The characteristics of the studied population are consistent with the usual population of AF patients referred for catheter ablation.(20) Patient outcomes are also consistent with prior reports, with recurrence rates (15% in paroxysmal and 35% in persistent AF over a 1-year median fol…”
Result
Association of bone morphogenetic protein 10 and recurrent atrial fibrillation after catheter ablation
Hennings, E., Aeschbacher, S., Coslovsky, M., Paladini, R. E., Meyre, P. B., Voellmin, G., Blum, L., Kastner, P., Ziegler, A., Conen, D., et al. (2023) · EP Europace · doi:10.1093/europace/euad149 · Cited by 21
“Among the different methods of rhythm control for atrial fibrillation (AF), catheter ablation (CA) represents a safe and effective alternative to antiarrhythmic drugs for maintaining sinus rhythm.(1,2) However, AF recurs in about one-third of patients after CA, which poses a major clinical challenge.”
Background
Atrial fibrillation: the rate versus rhythm management controversy
Aj, C., & Savelieva, I. (2012) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2012.s03 · Cited by 22
Minimally Invasive Radiofrequency Ablation of Lone Atrial Fibrillation by Monolateral Right Minithoracotomy: Operative and Early Follow-Up Results
Speziale, G., Bonifazi, R., Nasso, G., Bartolomucci, F., Caldarola, P., Fattouch, K., Martines, G., Tavazzi, L., & Chierchia, S. L. (2010) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2010.03.057 · Cited by 22
Visual, tactile, and contact force feedback: Which one is more important for catheter ablation? Results from an in vitro experimental study
Biase, L. D., Perini, A. P., Mohanty, P. K., Goldenberg, A. S., Grifoni, G., Santangeli, P., Santoro, F., Sánchez, J., Horton, R., Gallinghouse, G. J., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.11.016 · Cited by 22
Left Ventricular Hypertrophy and Antiarrhythmic Drugs in Atrial Fibrillation: Impact on Mortality
Chung, R., Houghtaling, P. L., Tchou, M. J., Niebauer, M. J., Lindsay, B. D., TCHOU, P. J., & Chung, M. K. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12426 · Cited by 22
Catheter Ablation of Atrial Fibrillation
Tung, R. H., Buch, E. F., & Shivkumar, K. (2012) · Circulation · doi:10.1161/circulationaha.111.048421 · Cited by 22
Imaging before cryoablation of atrial fibrillation: is phrenic nerve palsy predictable?
Canpolat, U., Aytemir, K., zal, M. H., rolan, T. H., Yorgun, H., ahiner, L., Kaya, E. B., & Oto, A. (2013) · EP Europace · doi:10.1093/europace/eut155 · Cited by 22
Evaluating the Cost-effectiveness of Catheter Ablation of Atrial Fibrillation
Chang, A. Y., Kaiser, D. W., Ullal, A. J., Perino, A. C., Heidenreich, P. A., Turakhia, M. P., & Veterans Affairs Palo Alto Health Care System, C. (2014) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2014.3.3.177 · Cited by 22
The usefulness of global left atrial strain for predicting atrial fibrillation recurrence after catheter ablation in patients with persistent and paroxysmal atrial fibrillation
Ma, X., Zhang, Y.-L., Hu, B., Zhu, M., Jiang, W., Wang, M., Zheng, D.-Y., & Xue, X. (2017) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2016.11.005 · Cited by 22
Anatomical predisposing factors of transmural thermal injury after pulmonary vein isolation
Kaneshiro, T., Matsumoto, Y., Nodera, M., Kamioka, M., Kamiyama, Y., Yoshihisa, A., Ohkawara, H., Suzuki, H., & Takeishi, Y. (2017) · EP Europace · doi:10.1093/europace/eux185 · Cited by 22
Safety of the Open‐Irrigated Ablation Catheter for Radiofrequency Ablation: Safety Analysis from Six Clinical Studies
Waldo, A. L., Wilber, D. J., Marchlinski, F. E., Stevenson, W. G., AKER, B., Boo, L. M., & Jackman, W. M. (2012) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2012.03480.x · Cited by 22
Atrial fibrillation
Lane, D. A., Andrade, J. G., Arbelo, E., Boriani, G., Hendriks, J., Lee, S., Lip, G. Y. H., Mant, J., & Middeldorp, M. E. (2026) · The Lancet · doi:10.1016/s0140-6736(25)02166-x · Cited by 25
Prognostic significance of atrial fibrillation in acute decompensated heart failure with reduced versus preserved ejection fraction
Jobs, A., Schwind, J., Katalinic, A., Babaev, V., Tilz, R. R., Rausch, S., Thiele, H., Eitel, I., & Eitel, C. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1321-4 · Cited by 21
Variability of P-wave morphology predicts the outcome of circumferential pulmonary vein isolation in patients with recurrent atrial fibrillation
Huo, Y., Holmqvist, F., Carlson, J., Gaspar, T., Hindricks, G., Piorkowski, C., Bollmann, A., & Platonov, P. G. (2014) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2014.11.011 · Cited by 21
“Over the last decade, studies of radiofrequency catheter ablation for treatment of AF reported higher efficacy rates than did studies of antiarrhythmic drug therapy [9–12].”
Result
Long-Term Benefits Following Catheter Ablation of Atrial Fibrillation
Latchamsetty, R., & Morady, F. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0298 · Cited by 21
The effect of integrated cardiac rehabilitation versus treatment as usual for atrial fibrillation patients treated with ablation: the randomised CopenHeart RFA trial protocol
Risom, S. S., Zwisler, A., Rasmussen, T. B., Sibilitz, K. L., Svendsen, J. H., Gluud, C. N., Hansen, J. L., Winkel, P., Thygesen, L. C., Perhonen, M. A., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002377 · Cited by 21
“RFA is an invasive treatment, intended to cure AF, and has a success rate of 77% versus 52% for antiarrhythmic medication.(15) In Denmark, around 600 RFAs are conducted annually at two heart centres.”
Background
High-sensitive cardiac troponin T as a novel predictor for recurrence of atrial fibrillation after radiofrequency catheter ablation
Nakanishi, K., Fukuda, S., Yamashita, H., Hasegawa, T., Kosaka, M., Shirai, N., Shimada, K., Yoshikawa, J., & Tanaka, A. (2017) · EP Europace · doi:10.1093/europace/euw314 · Cited by 21
Atrial Fibrillation and Risk of Dementia/Cognitive Decline.
SHAH, A. D., Merchant, F. M., & DeLurgio, D. B. (2016) · PubMed · doi:10.4022/jafib.1353 · Cited by 21
The Past, the Present, and the Future of Cardiac Arrhythmia Ablation
Andrade, J. G., Rivard, L., & Macle, L. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.07.731 · Cited by 22
Repeat ablation or medical management alone for recurrent arrhythmias after ablation of persistent atrial fibrillation
Barakat, A. F., Wazni, O. M., Saliba, W. I., Yzeiraj, E., Amuthan, R., Rehman, K. A., Tarakji, K. G., Bassiouny, M., Baranowski, B. J., TCHOU, P. J., et al. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13434 · Cited by 21
Perioperative Safety and Efficacy of Different Anticoagulation Strategies With Direct Oral Anticoagulants in Pulmonary Vein Isolation
Gorla, R., Dentali, F., Crippa, M., Marazzato, J., Minno, M. N. D. D., Grandi, A. M., & Ponti, R. D. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.04.006 · Cited by 20
“interrupted for OB) is comparable to or even lower than that reported in large prospective studies (58–60), administrative databases (61–64), meta-analyses (65,66), and surveys (67,68) published over the past decade on patients mainly treated with vitamin K antagonists.”
Result
Radiofrequency Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation: Meta-analysis of Safety and Efficacy
Fang, Y., Hou, W., Zhou, C. Y., Yin, Y., Lu, S., Duan, C., Cao, M., Li, M., Toft, E. S., & Zhang, H. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000654 · Cited by 20
Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
Roh, S., Lee, D. I., Hwang, S. H., Lee, K., Baek, Y., Iqbal, M., Kim, D., Ahn, J., Shim, J., Choi, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72929-0 · Cited by 20
Update on the management of atrial fibrillation
Amerena, J. V., Walters, T. E., Mirzaee, S., & Kalman, J. M. (2013) · The Medical Journal of Australia · doi:10.5694/mja13.10191 · Cited by 20
Rate and rhythm control have comparable effects on mortality and stroke in atrial fibrillation but better data are needed
Kotecha, D., & Kirchhof, P. F. (2014) · BMJ Evidence-Based Medicine · doi:10.1136/ebmed-2014-110062 · Cited by 20
“4 Another study previously confirmed that catheter ablation maintains sinus rhythm better than AAD alone.(5) The clinical application of these findings is troublesome, particularly as this review combines tabular data from different types of AF, which diverge in terms of mechanism, prognosis and the response to treatm…”
Background
Executive Summary of the II Brazilian Guidelines for Atrial Fibrillation
de Magalhães, L. P., Figueiredo, M. J. D. O., Cintra, F. D., Saad, E., Kuniyoshi, R. R., Filho, A. M. L., d’Ávila, A., de Paola, Â. A. V., Kalil, C., Moreira, D. A. R., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160190 · Cited by 19
Predictors of Atrial Fibrillation Recurrence after Catheter Ablation.
Epicoco, G., & Sorgente, A. (2014) · Europe PMC (PubMed Central) · doi:10.4022/jafib.1016 · Cited by 20
EURASIAN CLINICAL RECOMMENDATIONS ON DIAGNOSIS AND TREATMENT OF ATRIAL FIBRILLATION
Sp, G., Панченко, Е. П., Станиславовна, К. Е., Laiovich, L. I., Maykov, E. B., Mironov, N. Y., & Shakhmatova, O. O. (2019) · Eurasian heart journal · doi:10.38109/2225-1685-2019-4-4-85 · Cited by 21
Usefulness of empiric superior vena cava isolation in paroxysmal atrial fibrillation ablation: a meta-analysis of randomized clinical trials
Mariani, M. V., Palombi, M., Jabbour, J. P., Pierucci, N., Cipollone, P., Piro, A., Chimenti, C., Miraldi, F., Vizza, C. D., & Lavalle, C. (2024) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-024-01867-y · Cited by 19
Long-Term Differences in Autonomic Alterations After Cryoballoon vs Radiofrequency Atrial Fibrillation Ablation
Andrade, J. G., Bennett, R. G., Deyell, M. W., Bennett, M., Phulka, J., Hawkins, N. M., Aksu, T., Field, T. S., Aguilar, M., Khairy, P., et al. (2024) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2024.09.003 · Cited by 20
Predictive value of B-type natriuretic peptide levels in patients with paroxysmal and persistent atrial fibrillation undergoing pulmonary vein isolation
Degener, S., Pattberg, S. V., Feuersenger, H., Bansmann, P. M., Shin, D., Krummenauer, F., & Horlitz, M. (2011) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-010-9540-2 · Cited by 19
“The risk of major complications such as stroke, transient ischemic attacks, and pericardial tamponade is about 5% [12, 13 ].”
Background

Authors: Calkins, H., Reynolds, M. R., Spector, P., Sondhi, M., Xu, Y., Martin, A., Williams, C. J., & Sledge, I.
Affiliations: University of Vermont (US)
ORCID: Calkins, Hugh
Reynolds, Matthew R.
Spector, Peter
Martin, Amber
Venue: Circulation Arrhythmia and Electrophysiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-08
Volume: 2
Issue: 4
Pages: 349-361
ISSN: 1941-3084 (ISSN-L)
1941-3149
DOI: 10.1161/circep.108.824789
OpenAlex: W2020741490
Cited by: 847
References: 128
Citations by year: 2026: 19 · 2025: 29 · 2024: 42 · 2023: 33 · 2022: 38 · 2021: 48 · 2020: 35 · 2019: 37 · 2018: 43 · 2017: 54 · 2016: 62 · 2015: 63 · 2014: 72 · 2013: 69 · 2012: 74
FWCI: 43.34
Type: journal article
Language: en
Open access: closed
Locations: Circulation Arrhythmia and Electrophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: atrial fibrillation, radiofrequency catheter ablation, antiarrhythmic drugs, amiodarone, dofetilide, sotalol, flecainide, propafenone, treatment efficacy, procedural complications, ablation success rate
MeSH terms: Anti-Arrhythmia Agents, Atrial Fibrillation, Humans, Catheter Ablation

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Treatment of Atrial Fibrillation With Antiarrhythmic Drugs or Radiofrequency Ablation: Two Systematic Literature Reviews and Meta-Analyses

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