Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis
Open accessAbstract
The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with age, with at least 1 in 10 adults older than 70 years affected. Carriers of clonal hematopoiesis have been shown to be not only at heightened risk for hematologic malignancy but also at increased risk for atherosclerotic cardiovascular disease. Here, we review the prior literature of clonal selection and expansion of hematopoietic stem cells and the evidence supporting its causal association with atherosclerotic cardiovascular disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These molecules enhance inflammation locally within atherosclerotic plaques by increasing chemotaxis of leukocytes to arterial intima.
“These molecules are thought to enhance inflammation locally within atherosclerotic plaques by increasing chemotaxis of leukocytes to arterial intima”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [93]
The enhanced inflammation locally within atherosclerotic plaques potentially explains the accelerated atherosclerosis seen with loss of Tet2.
“which potentially explains the accelerated atherosclerosis seen with loss of Tet2 93”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [93]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 148 · Cited by 63
- Authors
- Natarajan, P., Jaiswal, S., & Kathiresan, S.
- Affiliations
- Broad Institute (US)
- Stanford Medicine (US)
- Venue
- Circulation Genomic and Precision Medicine
- Published
- 2018-07
- Volume
- 11
- Issue
- 7
- Pages
- e001926-e001926
- ISSN
- 2574-8300 (ISSN-L)
- PMC
- PMC6082163
- OpenAlex
- W2866344331
- Cited by
- 63
- References
- 148
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 8 · 2018: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Genomic and Precision Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K08HL140203)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- clonal hematopoiesis, somatic mutations, atherosclerotic cardiovascular disease, hematologic malignancy risk, hematopoietic stem cells, clonal selection, clonal expansion, aging, exome sequencing, cardiovascular risk
- MeSH terms
- Aged, Aging, Female, Hematopoiesis, Hematopoietic Stem Cells, Humans, Male, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
