Nutrigenomics in Cardiovascular Medicine
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A major challenge for candidate gene approaches has been lack of replication.
“While candidate genes approaches have identified several potential gene-diet interactions for traits including blood cholesterol levels, a major challenge has been lack of replication.74-77”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [74]
Candidate gene approaches have identified several potential gene-diet interactions for traits including blood cholesterol levels.
“While candidate genes approaches have identified several potential gene-diet interactions for traits including blood cholesterol levels, a major challenge has been lack of replication.74-77”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [74]
Even for better documented gene-diet interactions (APOE locus, dietary saturated fat, LDL-cholesterol; CETP locus, alcohol, HDL-cholesterol), evidence for clinical relevance of these differences remains weak.
“Even for better documented gene-diet interactions – e.g., for the APOE locus, dietary saturated fat, and LDL-cholesterol; or the CETP locus, alcohol, and HDL-cholesterol – evidence for clinical relevance of these differences remains weak.74”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [74]
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References 123 · Cited by 138
- Authors
- Corella, D., & Ordovas, J. M.
- Affiliations
- Tufts University (US)
- From the Nutrition and Genomics Laboratory (D.C., J.M.O.), JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass; Genetic and Molecular Epidemiology Unit and CIBER Fisiopatología de la Obesidad y Nutrición as an initiative of the ISCIII (D.C.), School of Medicine, University of Valencia, Valencia, Spain; and Department of Cardiovascular Epidemiology and Population Genetics (J.M.O.), Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
- ORCID
- Corella, Dolores
- Venue
- Circulation: Cardiovascular Genetics
- Published
- 2009-12
- Volume
- 2
- Issue
- 6
- Pages
- 637-651
- ISSN
- 1942-325X (ISSN-L)
- 1942-3268
- PMC
- PMC2810265
- OpenAlex
- W2128785308
- Cited by
- 138
- References
- 123
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 12 · 2016: 5 · 2015: 5 · 2014: 16 · 2013: 11 · 2012: 13
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Cardiovascular Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL54776, U01HL072524, R01HL054776)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-075030, R01DK075030)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- nutrigenomics, cardiovascular disease, gene-diet interaction, cardiovascular genetics, personalized nutrition
- MeSH terms
- Animals, Cardiovascular Diseases, Diet, Humans, Medicine, Nutrigenomics
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