The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
Open accessAbstract
Background—: Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We have investigated the association of 2 478 304 single-nucleotide polymorphisms with incident HF by meta-analyzing data from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study. Methods and Results—: Eligible participants for these analyses were of European or African ancestry and free of clinical HF at baseline. Each study independently conducted genome-wide scans and imputed data to the ≈2.5 million single-nucleotide polymorphisms in HapMap. Within each study, Cox proportional hazards regression models provided age- and sex-adjusted estimates of the association between each variant and time to incident HF. Fixed-effect meta-analyses combined results for each single-nucleotide polymorphism from the 4 cohorts to produce an overall association estimate and P value. A genome-wide significance P value threshold was set a priori at 5.0×10 −7 . During a mean follow-up of 11.5 years, 2526 incident HF events (12%) occurred in 20 926 European-ancestry participants. The meta-analysis identified a genome-wide significant locus at chromosomal position 15q22 (1.4×10 −8 ), which was 58.8 kb from USP3 . Among 2895 African-ancestry participants, 466 incident HF events (16%) occurred during a mean follow-up of 13.7 years. One genome-wide significant locus was identified at 12q14 (6.7×10 −8 ), which was 6.3 kb from LRIG3 . Conclusions—: We identified 2 loci that were associated with incident HF and exceeded genome-wide significance. The findings merit replication in other community-based settings of incident HF.
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Self-citationHeart disease and stroke statistics-2018 update: a report from the american heart association
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Self-citationHeart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
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Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
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Metadata
- Authors
- Smith, N. L., Felix, J. F., Morrison, A. C., Demissie, S., Glazer, N. L., Loehr, L. R., Cupples, L. A., Dehghan, A., Lumley, T., Rosamond, W. D., Lieb, W., Rivadeneira, F., Bis, J. C., Folsom, A. R., Benjamin, E., Aulchenko, Y. S., Haritunians, T., Couper, D., Murabito, J., Wang, Y. A., Stricker, B. H., Gottdiener, J. S., Chang, P. P., Wang, T. J., Rice, K. M., Hofman, A., Heckbert, S. R., Fox, E. R., O'Donnell, C. J., Uitterlinden, A. G., Rotter, J. I., Willerson, J. T., Levy, D., van Duijn, C. M., Psaty, B. M., Witteman, J. C. M., Boerwinkle, E., & Vasan, R. S.
- Venue
- Circulation: Cardiovascular Genetics
- Published
- 2010-06
- Volume
- 3
- Issue
- 3
- Pages
- 256-266
- ISSN
- 1942-325X (ISSN-L)
- 1942-3268
- OpenAlex
- W2110624042
- Cited by
- 195
- References
- 10
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. https://app.cochat.ai/papers/10.1161/circgenetics.109.895763
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- Smith, N. L., Felix, J. F., Morrison, A. C., Demissie, S., Glazer, N. L., Loehr, L. R., Cupples, L. A., Dehghan, A., Lumley, T., Rosamond, W. D., Lieb, W., Rivadeneira, F., Bis, J. C., Folsom, A. R., Benjamin, E., Aulchenko, Y. S., Haritunians, T., Couper, D., Murabito, J., . . . Vasan, R. S. (2010). Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Circulation: Cardiovascular Genetics. https://doi.org/10.1161/circgenetics.109.895763
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
