The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Large Animal Models of Heart Failure: A Critical Link in the Translation of Basic Science to Clinical Practice
Open accessAbstract
Congestive heart failure (HF) is a clinical syndrome, with hallmarks of fatigue and dyspnea, that continues to be highly prevalent and morbid. Because of the growing burden of HF as the population ages, the need to develop new pharmacological treatments and therapeutic interventions is of paramount importance. Common pathophysiologic features of HF include changes in left ventricle structure, function, and neurohormonal activation. The recapitulation of the HF phenotype in large animal models can allow for the translation of basic science discoveries into clinical therapies. Models of myocardial infarction/ischemia, ischemic cardiomyopathy, ventricular pressure and volume overload, and pacing-induced dilated cardiomyopathy have been created in dogs, pigs, and sheep for the investigation of HF and potential therapies. Large animal models recapitulating the clinical HF phenotype and translating basic science to clinical applications have successfully traveled the journey from bench to bedside. Undoubtedly, large animal models of HF will continue to play a crucial role in the elucidation of biological pathways involved in HF and the development and refinement of HF therapies.
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Cites
Bone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J., McKay, R., Nadal-Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,155
A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure
Cohn, J. N., & Tognoni, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010713 · Cited by 3,108
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251
Reimer, K. A., Lowe, J. E., Rasmussen, M. M., & Jennings, R. B. (1977) · Circulation · doi:10.1161/01.cir.56.5.786 · Cited by 1,944
Intracoronary Injection of Mononuclear Bone Marrow Cells in Acute Myocardial Infarction
Lunde, K., Solheim, S., Aakhus, S., Arnesen, H., Abdelnoor, M., Egeland, T., Endresen, K., Ilebekk, A., Mangschau, A., Fjeld, J. G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055706 · Cited by 1,310
Reimer, K. A., & Jennings, R. B. (1979) · PubMed · Cited by 1,219
Amado, L. C., Saliaris, A. P., Schuleri, K. H., St. John, M., Xie, J.-S., Cattaneo, S., Durand, D. J., Fitton, T., Kuang, J. Q., Stewart, G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504388102 · Cited by 1,073
β-Adrenergic Receptor Blockade in Chronic Heart Failure
Bristow, M. R. (2000) · Circulation · doi:10.1161/01.cir.101.5.558 · Cited by 1,028
Meyer, G. P., Wollert, K. C., Lotz, J., Steffens, J., Lippolt, P., Fichtner, S., Hecker, H., Schaefer, A., Arseniev, L., Hertenstein, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.575118 · Cited by 991
Silva, G. V., Litovsky, S., Assad, J. A. R., Sousa, A. L. S., Martin, B. J., Vela, D., Coulter, S. C., Lin, J., Ober, J., Vaughn, W. K., et al. (2005) · Circulation · doi:10.1161/01.cir.0000151812.86142.45 · Cited by 801
Cited by
Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research · doi:10.1161/circresaha.117.305365 · Cited by 478
Small and large animal models in cardiac contraction research: advantages and disadvantages
Milani-Nejad, N., & Janssen, P. M. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.007 · Cited by 484
Animal Models of Heart Failure: A Scientific Statement From the American Heart Association
Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research · doi:10.1161/res.0b013e3182582523 · Cited by 435
Self-citationDiffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches
López, B., Ravassa, S., Moreno, M. U., José, G. S., Beaumont, J., González, A., & Díez, J. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00504-1 · Cited by 361
Pleger, S. T., Shan, C., Ksienzyk, J., Bekeredjian, R., Boekstegers, P., Hinkel, R., Schinkel, S., Leuchs, B., Ludwig, J., Qiu, G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002097 · Cited by 234
Metadata
- Authors
- Dixon, J. A., & Spinale, F. G.
- Venue
- Circulation: Heart Failure
- Published
- 2009-05
- Volume
- 2
- Issue
- 3
- Pages
- 262-271
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2547318251
- Cited by
- 294
- References
- 65
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dixon, J. A., & Spinale, F. G. (2009). Large Animal Models of Heart Failure: A Critical Link in the Translation of Basic Science to Clinical Practice. Circulation: Heart Failure. https://doi.org/10.1161/circheartfailure.108.814459
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
