CoChat
Sign Up
Cited by 644Cardiac Fibrosis and RemodelingCardiovascular Function and Risk FactorsHeart Failure Treatment and Management

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

Westermann, Dirk, Lindner, Diana, Kasner, Mario, Zietsch, Christine, Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, Paul, Riad, Alexander, Poller, Wolfgang, Schultheiss, Heinz-Peter, Tschöpe, Carsten·2011·Circulation Heart Failure
DOI 10.1161/circheartfailure.109.931451
Open this paper in CoChat — free account

Abstract

BACKGROUND: The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF. METHODS AND RESULTS: We investigated left ventricular systolic and diastolic function in 20 patients with HFNEF and 8 control patients by conductance catheter methods and echocardiography. Endomyocardial biopsy samples were also obtained, and ECM proteins as well as cardiac inflammatory cells were investigated. Primary human cardiac fibroblasts were outgrown from the endomyocardial biopsy samples to investigate the gene expression of ECM proteins after stimulation with transforming growth factor-β. Diastolic dysfunction was present in the HFNEF patients compared with the control patients. In endomyocardial biopsy samples from HFNEF patients, we found an accumulation of cardiac collagen, which was accompanied by a decrease in the major collagenase system (matrix metalloproteinase-1) in the heart. Moreover, a subset of inflammatory cells, which expressed the profibrotic growth factor transforming growth factor-β, could be documented in the HFNEF patients. Stimulation of primary human cardiac fibroblasts from HFNEF patients with transforming growth factor-β resulted in transdifferentiation of fibroblasts to myofibroblasts, which produced more collagen and decreased the amount of matrix metalloproteinase-1, the major collagenase in the human heart. A positive correlation between cardiac collagen, as well as the amount of inflammatory cells, and diastolic dysfunction was evident and suggests a direct influence of inflammation on fibrosis triggering diastolic dysfunction. CONCLUSIONS: Cardiac inflammation contributes to diastolic dysfunction in HFNEF by triggering the accumulation of ECM.

Overview

Integrity signals

Registry

Crossref · 10.1161/circheartfailure.109.931451

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 55 references

Cited by

Sorted by citations

Items 601–638 of 638

Related

See all

Metadata

Authors
Westermann, D., Lindner, D., Kasner, M., Zietsch, C., Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, P., Riad, A., Poller, W., Schultheiss, H.-P., & Tschöpe, C.
Affiliations
  • Leiden University Medical Center (NL)
  • From the Department of Cardiology and Pneumology (D.W., D.L., M.K., C.Z., K.S., F.E., J.v.S., C.S., A.R., W.P., H.-P.S., C.T.), Charité, Universititäts-Medizin Berlin, Campus Benjamin Franklin, Berlin, Germany, and Department of Cardiology (P.S.), Leiden University Medical Center, Leiden, The Netherlands.
ORCID
Venue
Circulation Heart Failure
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-01
Volume
4
Issue
1
Pages
44-52
ISSN
  • 1941-3289 (ISSN-L)
  • 1941-3297
DOI
10.1161/circheartfailure.109.931451
OpenAlex
W2131184290
Cited by
644
References
55
Citations by year
2026: 32 · 2025: 48 · 2024: 53 · 2023: 50 · 2022: 57 · 2021: 58 · 2020: 49 · 2019: 37 · 2018: 45 · 2017: 49 · 2016: 35 · 2015: 42 · 2014: 30 · 2013: 21 · 2012: 17
FWCI
12.97
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords
heart failure with preserved ejection fraction, cardiac inflammation, extracellular matrix remodeling, diastolic dysfunction, myocardial fibrosis, collagen deposition, MMP-1, TGF-beta, myofibroblasts, endomyocardial biopsy, left ventricular systolic function
MeSH terms
Adult, Aged, Biopsy, Cells, Cultured, Collagen, Extracellular Matrix, Female, Fibroblasts, Fibrosis, Heart, Heart Failure, Humans, Inflammation, Male, Middle Aged, Myocardium, Stroke Volume, Case-Control Studies, Transforming Growth Factor beta, Ventricular Function, Left, Extracellular Matrix Proteins, Disease Progression, Matrix Metalloproteinase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review