Habitual Coffee Consumption and Risk of Heart Failure: A Dose-Response Meta-Analysis
Open accessAbstract
Background—: There have been discrepant findings on the association between coffee consumption and risk of incident heart failure. Methods and Results—: We conducted a systematic review and a dose-response meta-analysis of prospective studies that assessed the relationship between habitual coffee consumption and the risk of heart failure. We searched electronic databases (MEDLINE, Embase, and CINAHL) from January 1966 through December 2011, with the use of a standardized protocol. Eligible studies were prospective cohort studies that examined the association of coffee consumption with incident heart failure. Five independent prospective studies of coffee consumption and heart failure risk, including 6522 heart failure events and 140 220 participants, were included in the meta-analysis. We observed a statistically significant J-shaped relationship between coffee and heart failure. Compared with no consumption, the strongest inverse association was seen for 4 servings/day and a potentially higher risk at higher levels of consumption. There was no evidence that the relationship between coffee and heart failure risk varied by sex or by baseline history of myocardial infarction or diabetes. Conclusions—: Moderate coffee consumption is inversely associated with risk of heart failure, with the largest inverse association observed for consumption of 4 servings per day.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prior meta-analyses of prospective cohort studies did not support an association between coffee consumption and a higher risk of cardiovascular disease.
“These meta-analyses did not support an association between coffee consumption and a higher CVD risk, but the shape of the association remains uncertain.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 29 · Cited by 185
- Authors
- Mostofsky, E., Rice, M. S., Levitan, E. B., & Mittleman, M. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Circulation: Heart Failure
- Published
- 2012-07
- Volume
- 5
- Issue
- 4
- Pages
- 401-405
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- PMC
- PMC3425948
- OpenAlex
- W2107269509
- Cited by
- 185
- References
- 29
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 9 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 25 · 2013: 17 · 2012: 5
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32-HL098048-03, T32HL098048)
- National Cancer Institute (T32-CA-09001-35, T32CA009001)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- coffee consumption, heart failure, J-shaped association, dose-response relationship, incident heart failure risk, sex differences, myocardial infarction, diabetes mellitus
- MeSH terms
- Central Nervous System Stimulants, Caffeine, Coffee, Dose-Response Relationship, Drug, Female, Heart Failure, Humans, Male, Risk Factors, Incidence, Odds Ratio, Nonlinear Dynamics, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
