Renal Sympathetic Denervation in Patients With Heart Failure With Preserved Ejection Fraction
Abstract
Background Arterial hypertension is the most common comorbidity in patients with heart failure with preserved ejection fraction (HFpEF) and mediates adverse hemodynamics through related aortic stiffness and increased pulsatile load. We aimed to investigate the clinical and hemodynamic implications of renal sympathetic denervation (RDN) in patients with HFpEF and uncontrolled arterial hypertension. Methods Patients undergoing RDN between 2011 and 2018 in a single-center were retrospectively analyzed and classified as HFpEF (n=99) or no HF (n=65). Stroke volume index and aortic distensibility were measured through cardiac magnetic resonance imaging, and left ventricular (LV) systolic and diastolic properties were assessed echocardiographically. Results At baseline, patients with HFpEF had higher stroke volume index (median 40 [interquartile range, 33-48] versus 33 [26-40] mL/m 2 , P =0.002), pulse pressure (69 [63-77] versus 61 [55-67] mm Hg, P 100mm Hg (18 [10-28] versus 24 [15-40] mL, P =0.007) and aortic distensibility (1.5 [1.1-2.6] versus 2.7 [1.1-3.5] 10 -3 mm Hg -1 , P =0.013) as compared to no-HF patients. Systolic blood pressure decreased comparable in patients with HFpEF and no-HF patients following RDN (-9 [-16 to -2], P 2 , P =0.011) decreased and aortic distensibility (0.2 [-0.1 to +1.1] 10 -3 mm Hg -1 , P =0.007) and systolic stiffness ( P P =0.032, P =0.043, and P Conclusions Patients with HFpEF undergoing RDN showed increased stroke volume index, vascular, and L…
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A retrospective observational study of patients with heart failure with preserved ejection fraction found that renal denervation was associated with improved cardiac function, including reductions in stroke volume index, left ventricular diastolic stiffness, left ventricular filling pressures and N-terminal pro-B-type natriuretic peptide levels.
“A retrospective observational study that analysed data from patients with HFpEF who underwent RDN at a single centre between 2011 and 2018, found that the procedure was associated with improved cardiac function150. The beneficial effects of RDN included reductions in stroke volume index, left ventricular diastolic stiffness, left ventricular filling pressures and NT-proBNP levels150.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [150]
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References 42 · Cited by 96
- Authors
- Kresoja, K.-P., Rommel, K.-P., Fengler, K., von Roeder, M., Besler, C., Lücke, C., Gutberlet, M., Desch, S., Thiele, H., Böhm, M., & Lurz, P.
- Affiliations
- Leipzig Heart Institute (DE)
- Leipzig University (DE)
- Department of Cardiology (K.-P.K., K.-P.R., K.F., M.v.R., C.B., S.D., H.T., P.L.), Heart Center Leipzig, University of Leipzig, Germany.
- University Hospital Leipzig (DE)
- Universitätsklinikum des Saarlandes (DE)
- Corresponding author
- Lurz, Philipp
- ORCID
- Venue
- Circulation: Heart Failure
- Published
- 2021-03
- Volume
- 14
- Issue
- 3
- Pages
- e007421-e007421
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W3133759837
- Cited by
- 96
- References
- 42
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 26 · 2023: 15 · 2022: 17 · 2021: 10
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- renal denervation, heart failure with preserved ejection fraction, hypertension, aortic stiffness, stroke volume index, aortic distensibility, left ventricular diastolic stiffness, left ventricular filling pressure, hemodynamics, blood pressure reduction, cardiac magnetic resonance imaging, echocardiography, left ventricular ejection
- MeSH terms
- Aged, Aorta, Blood Pressure, Echocardiography, Female, Heart Failure, Humans, Hypertension, Magnetic Resonance Imaging, Male, Middle Aged, Peptide Fragments, Renal Artery, Retrospective Studies, Stroke Volume, Sympathectomy, Treatment Outcome, Ventricular Pressure, Magnetic Resonance Imaging, Cine, Natriuretic Peptide, Brain, Ablation Techniques, Vascular Stiffness
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