Characterization of 18 F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves
Abstract
Background 18 F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been recently acknowledged as a diagnostic tool for prosthetic valve endocarditis, but its specificity is limited by uptake on noninfected valves. The objective of this study was to outline the main features of FDG uptake on PET/CT in patients with noninfected prosthetic heart valve (PHV). Methods and results Our institution's PET/CT database was reviewed to identify patients with PHV, excluding those suspected of infection or who had received antibiotic treatment. PET indication, valve location, and type (biological/mechanical) and time from implantation were collected for each patient. Images with and without attenuation correction were considered for interpretation. The pattern of FDG uptake (absent, homogeneous, or heterogeneous) was recorded. Fifty-four PHVs (51 patients) were identified, including 32 biological valves. Indications for PET were oncology (n=26), suspicion of prosthetic valve endocarditis subsequently excluded (n=17), and history of vasculitis (n=11). A periprosthetic FDG uptake was present in 47 (87%) and 30 (56%) PHVs with and without attenuation correction, respectively, and the pattern was homogeneous in all but 4 (7%) and 3 (6%) PHVs, respectively. On quantitative analysis, maximum standardized uptake values was greater in mechanical than in biological valves (4.0 [2.4-8.0] versus 3.3 [2.1-6.1]; P =0.01) and in patients with vasculitis than in those…
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In cardiovascular imaging, postoperative changes or sterile inflammation can be difficult to differentiate from active infection.
“while postoperative changes or sterile inflammation can be difficult to differentiate from active infection [136,137,138].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [138]
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- Authors
- Mathieu, C., Mikaïl, N., Benali, K., Iung, B., Duval, X., Nataf, P., Jondeau, G., Hyafil, F., Le Guludec, D., & Rouzet, F.
- Affiliations
- Inserm (FR)
- From the Department of Nuclear Medicine, Bichat Hospital, Assistance Publique-Hôpitaux de Paris (APHP) and DHU FIRE, France (C.M., N.M., K.B., F.H., D.L.G., F.R.); Paris-Diderot University, France (N.M., K.B., B.I., X.D., P.N., G.J., F.H., D.L.G., F.R.); Inserm Unité Mixte de Recherche U1148, LVTS (N.M., K.B., B.I., P.N., G.J., F.H., D.L.G., F.R.); Department of Cardiology, Bichat Hospital, Assistance Publique Hôpitaux de Paris (APHP) and DHU FIRE, France (B.I., G.J.); Inserm Clinical Investigation...
- ORCID
- Venue
- Circulation: Cardiovascular Imaging
- Published
- 2017-03
- Volume
- 10
- Issue
- 3
- Pages
- e005585-e005585
- ISSN
- 1941-9651 (ISSN-L)
- 1942-0080
- OpenAlex
- W2977456061
- Cited by
- 102
- References
- 24
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 12 · 2023: 6 · 2022: 9 · 2021: 15 · 2020: 17 · 2019: 9 · 2018: 9 · 2017: 11
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Cardiovascular Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- 18F-fluorodeoxyglucose uptake, prosthetic valve endocarditis, FDG PET/CT, attenuation correction, standardized uptake value, vasculitis, FDG uptake patterns
- MeSH terms
- Positron Emission Tomography Computed Tomography, Adult, Aged, Aged, 80 and over, Female, Heart Valve Prosthesis, Heart Valves, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Tissue Distribution, Reproducibility of Results, Databases, Factual, Treatment Outcome, Radiopharmaceuticals, Fluorodeoxyglucose F18, Heart Valve Prosthesis Implantation
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