Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm

Toczek, Jakub; Gona, Kiran; Liu, Yongjian; Ahmad, Azmi; Ghim, Mean; Ojha, Devi; Kukreja, Gunjan; Salarian, Mani; Luehmann, Hannah; Heo, Gyu Seong; Guzman, Raul J.; Ochoa Chaar, Cassius I.; Tellides, George; Hassab, Abdulrahman H.M.; Ye, Yunpeng; Shoghi, Kooresh I.; Zayed, Mohamed A.; Gropler, Robert J.; Sadeghi, Mehran M.

doi:10.1161/circimaging.122.014615

Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm

Background: Matrix metalloproteinases (MMPs) play a key role in the pathogenesis of abdominal aortic aneurysm (AAA). Imaging aortic MMP activity, especially using positron emission tomography to access high sensitivity, quantitative data, could potentially improve AAA risk stratification. Here, w…