The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Economic Impact of Angina After an Acute Coronary Syndrome: Insights From the MERLIN-TIMI 36 Trial
Abstract
Background— Angina in patients with coronary artery disease is associated with worse quality of life; however, the relationship between angina frequency and resource utilization is unknown. Methods and Results— Using data from the MERLIN-TIMI 36 trial, we assessed the association between the extent of angina after an acute coronary syndrome (ACS) and subsequent cardiovascular resource utilization among 5460 stable outpatients who completed the Seattle Angina Questionnaire at 4 months after an ACS and who were then followed for an additional 8 months. Angina frequency was categorized as none (score, 100; 2739 patients), monthly (score, 61 to 99; 1608 patients), weekly (score, 31 to 60; 854 patients), and daily (score, 0 to 30; 259 patients). Multivariable regression models evaluated the association between angina frequency and overall costs attributable to cardiovascular hospitalizations, outpatient visits and procedures, and medications. As compared with no angina, overall costs increased in a graded fashion with higher angina frequency—no angina, $2928 (reference); monthly angina, $3909 (adjusted relative cost ratio, 1.29; 95% CI, 1.21 to 1.39); weekly angina, $4558 (adjusted relative cost ratio, 1.52; 95% CI, 1.48 to 1.67); and daily angina, $6949 (adjusted relative cost ratio, 2.32; 95% CI, 2.01 to 2.69; P for trend <0.001). Differences in costs were attributable primarily to higher rates of ACS hospitalization and coronary revascularization among patients with more severe angina. Conclusion— Among stable outpatients after ACS, a direct graded relationship was found between higher angina frequency and healthcare costs. As compared with patients without angina, patients with daily angina had a >2-fold increase in resource utilization and incremental costs of $4000 after 8 months of follow-up.
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“but also is associated with increased hospitalizations and healthcare costs”
From Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: a scientific statement from the American Heart Association (2020) · cites this paper as [236]
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Cites
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,799
The TIMI Risk Score for Unstable Angina/Non–ST Elevation MI
Antman, E. M., Cohen, M. C., Bernink, P. J. L. M., McCabe, C. H., Horacek, T., Papuchis, G., Mautner, B., Corbalán, R., Radley, D. R., & Braunwald, E. (2000) · JAMA · doi:10.1001/jama.284.7.835 · Cited by 3,221
Use of a Continuous-Flow Device in Patients Awaiting Heart Transplantation
Miller, L. W., Pagani, F. D., Russell, S. D., John, R., Boyle, A. J., Aaronson, K. D., Conte, J. V., Naka, Y., MANCINI, D. M., Delgado, R. M., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067758 · Cited by 1,734
Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis
Stettler, C., Wandel, S., Allemann, S., Kastrati, A., Morice, M., Schömig, A., Pfisterer, M. E., Stone, G. W., Leon, M. B., de Lezo, J. S., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61444-5 · Cited by 1,435
Spertus, J., Winder, J. A., Dewhurst, T. A., Deyo, R., Prodzinski, J., McDonnell, M., & Fihn, S. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00397-9 · Cited by 1,413
Erbel, R. M., Mario, C. D., Bartúnek, J., Bonnier, J. J. R. M., Bruyne, B. D., Eberli, F. R., Erné, P., Haude, M., Heublein, B., Horrigan, M., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60853-8 · Cited by 908
CHAITMAN, B. R., Skettino, S. L., Parker, J. O., Hanley, P. C., Meluzı́n, J., Kuch, J., Pepine, C. J., Wang, W., Nelson, J. J., Hebert, D. A., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.045 · Cited by 567
Intramyocardial Transplantation of Autologous CD34 + Stem Cells for Intractable Angina
Losordo, D. W., Schatz, R. A., White, C. J., Udelson, J. E., Veereshwarayya, V., Durgin, M., Poh, K. K., Weinstein, R. S., Kearney, M., Chaudhry, M. S., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.687376 · Cited by 553
Health Status Predicts Long-Term Outcome in Outpatients With Coronary Disease
Spertus, J., Jones, P. G., McDonell, M., Fan, V., & Fihn, S. (2002) · Circulation · doi:10.1161/01.cir.0000020688.24874.90 · Cited by 528
Morrow, D. A. (2007) · JAMA · doi:10.1001/jama.297.16.1775 · Cited by 506
Self-citationArora, R. R., Chou, T. M., Jain, D., Fleishman, B. L., Crawford, L. E., McKiernan, T. L., & Nesto, R. W. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00140-0 · Cited by 492
Monitoring the quality of life in patients with coronary artery disease.
Spertus, J. A., Winder, J. A., Dewhurst, T. A., Deyo, R., & Fihn, S. D. (1994) · American Journal of Cardiology · doi:10.1016/0002-9149(94)90555-x · Cited by 435
Schofield, P. M., Sharples, L. D., Caine, N., Burns, S., Tait, S., Wistow, T., Buxton, M. J., & Wallwork, J. L. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11478-2 · Cited by 359
Antianginal Efficacy of Ranolazine When Added to Treatment With Amlodipine
Stone, P. H., Gratsiansky, N. A., Blokhin, A., Huang, I., & Meng, L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.044 · Cited by 353
Wiviott, S. D., Antman, E. M., Gibson, C. M., Montalescot, G., Riesmeyer, J. S., Weerakkody, G. J., Winters, K. J., Warmke, J. W., McCabe, C. H., & D, E. B. M. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.04.012 · Cited by 323
Predictors of Quality-of-Life Benefit After Percutaneous Coronary Intervention
Spertus, J. A., Salisbury, A. C., Jones, P. G., Conaway, D. G., & Thompson, R. C. (2004) · Circulation · doi:10.1161/01.cir.0000150392.70749.c7 · Cited by 189
A randomised controlled trial of a self-management plan for patients with newly diagnosed angina.
Lewin, R., Furze, G., Robinson, J., Griffith, K., Wiseman, S., Pye, M. P., & Boyle, R. (2002) · Europe PMC (PubMed Central) · Cited by 142
Soran, O. Z., Kennard, E. D., Kfoury, A. G., & Kelsey, S. F. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.07.122 · Cited by 124
Stone, G. W., Teirstein, P. S., Rubenstein, R., Schmidt, D. H., Whitlow, P. L., Kosinski, E. J., Mishkel, G. J., & Power, J. A. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01829-6 · Cited by 117
Anginal symptoms consistently predict total mortality among outpatients with coronary artery disease
Mozaffarian, D., Bryson, C. L., Spertus, J. A., McDonell, M. B., & Fihn, S. D. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00436-8 · Cited by 113
Challenges and Opportunities in Quantifying the Quality of Care for Acute Myocardial Infarction
Spertus, J. A., Radford, M. J., Every, N. R., Ellerbeck, E. F., Peterson, E. D., & Krumholz, H. M. (2003) · Circulation · doi:10.1161/01.cir.0000062026.90014.63 · Cited by 111
Kim, J., Henderson, R. A., Pocock, S., Clayton, T. C., Sculpher, M. J., & Fox, K. A. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.10.034 · Cited by 110
Ruhparwar, A. (2008) · Circulation · doi:10.1161/circulationaha.107.188511 · Cited by 108
Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus
Reed, S., Anstrom, K. J., Bakhai, A., Briggs, A. H., Califf, R. M., Cohen, D. J., Drummond, M., Glick, H. A., Gnanasakthy, A., Hlatky, M. A., et al. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.11.001 · Cited by 93
Self-citationPatient Health Status and Costs in Heart Failure
Chan, P. S., Soto, G. E., Jones, P. G., Nallamothu, B. K., Zhang, Z., Weintraub, W. S., & Spertus, J. A. (2009) · Circulation · doi:10.1161/circulationaha.108.820472 · Cited by 88
Self-citationBoden, W. E., O’Rourke, R. A., Teo, K. K., Hartigan, P. M., Maron, D. J., Kostuk, W. J., Knudtson, M. L., Dada, M. R., Casperson, P. R., Harris, C. L., et al. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.08.015 · Cited by 87
Morrow, D. A., Scirica, B. M., Karwatowska‐Prokopczuk, E., Skene, A. M., McCabe, C. H., & Braunwald, E. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.01.004 · Cited by 73
Self-citationMaddox, T. M., Reid, K. J., Rumsfeld, J. S., & Spertus, J. A. (2007) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-7-28 · Cited by 44
Zhang, Z., Spertus, J. A., Mahoney, E. M., Booth, J., Nugara, F., Stables, R., & Weintraub, W. S. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.01.019 · Cited by 33
Self-citationPrevalence and Predictors of Angina Pectoris One Month After Myocardial Infarction
Spertus, J. A., Dawson, J., Masoudi, F. A., Krumholz, H. M., Reid, K. J., Peterson, E. D., & Rumsfeld, J. S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.01.099 · Cited by 31
Routine functional testing after percutaneous coronary intervention
Eisenberg, M. J., Wilson, B. E., Lauzon, C., HUYNH, T., Eisenhauer, M. D., Mak, K. H., Blankenship, J., DOUCET, M., & Pilote, L. (2007) · Acta Cardiologica · doi:10.2143/ac.62.2.2020234 · Cited by 24
Research works printed but not linked: 1
- Red Book (Red Book Drug Topics). 109th edition. Florence Ky: Thompson Healthcare; 2005.
Cited by
Sorted by citations
Fihn, S. D., Gardin, J. M., Abrams, J., Berra, K., Blankenship, J. C., Dallas, A. P., Douglas, P. S., Foody, J. M., Gerber, T. C., Hinderliter, A. L., et al. (2012) · Circulation · doi:10.1161/cir.0b013e3182776f83 · Cited by 2,419
Fihn, S. D., Gardin, J. M., Abrams, J., Berra, K., Blankenship, J. C., Dallas, A. P., Douglas, P. S., Foody, J. M., Gerber, T. C., Hinderliter, A. L., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.013 · Cited by 1,583
Fihn, S. D., Gardin, J. M., Abrams, J., Berra, K., Blankenship, J. C., Dallas, A. P., Douglas, P. S., Foody, J. M., Gerber, T. C., Hinderliter, A. L., et al. (2012) · Circulation · doi:10.1161/cir.0b013e318277d6a0 · Cited by 845
Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease
Spertus, J. A., Jones, P. G., Maron, D. J., O’Brien, S. M., Reynolds, H. R., Rosenberg, Y., Stone, G. W., Harrell, F. E., Boden, W. E., Weintraub, W. S., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1916370 · Cited by 487
Self-citationSafdar, B., Spatz, E. S., Dreyer, R. P., Beltrame, J. F., Lichtman, J. H., Spertus, J. A., Reynolds, H. R., Geda, M. E., Bueno, H., Dziura, J. D., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009174 · Cited by 453
Metadata
- Authors
- Arnold, S. V., Morrow, D. A., Lei, Y., Cohen, D. J., Mahoney, E. M., Braunwald, E., & Chan, P. S.
- Affiliations
- Brigham and Women's Hospital (US)
- From the Saint Luke’s Mid America Heart Institute (S.V.A., Y.L., D.J.C., E.M.M., P.S.C.), Kansas City, Mo; and the TIMI Study Group (D.A.M., E.B.), Brigham and Women’s Hospital, Boston, Mass.
- Venue
- Circulation: Cardiovascular Quality and Outcomes
- Published
- 2009-07
- Volume
- 2
- Issue
- 4
- Pages
- 344-353
- ISSN
- 1941-7705 (ISSN-L)
- 1941-7713
- OpenAlex
- W2887283102
- Cited by
- 128
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 4 · 2021: 17 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 19 · 2014: 9 · 2013: 6 · 2012: 7
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Cardiovascular Quality and Outcomes (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- angina frequency, acute coronary syndrome, health care costs, resource utilization (health care), coronary artery disease, Seattle Angina Questionnaire, hospitalization, coronary revascularization, stable outpatients
- MeSH terms
- Ranolazine, Acetanilides, Aged, Ambulatory Care, Angina Pectoris, Costs and Cost Analysis, Enzyme Inhibitors, Female, Follow-Up Studies, Health Status, Hospitalization, Humans, Male, Middle Aged, Piperazines, Quality of Life, Surveys and Questionnaires, Health Care Costs, Kaplan-Meier Estimate, Acute Coronary Syndrome
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