The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Forgotten but Not Gone: The Rediscovery of Fatty Heart, the Most Common Unrecognized Disease in America
Abstract
Until 60 years ago, fatty heart was an accepted clinical entity. Since then, its very existence has been questioned, despite the fact that 2 of 3 Americans are now obese or overweight and obesity has been shown to be correlated with cardiac functional abnormalities. In 2000, a syndrome of “lipotoxic cardiomyopathy” resembling earlier pathologic descriptions of fatty human hearts was described in rodents, and fatty infiltration of cardiomyocytes was subsequently reported in patients with congestive failure. Now, magnetic resonance spectroscopy has been adapted to permit routine noninvasive screening for fatty heart. The use of this technique in human volunteers indicates that cardiomyocyte fat correlates well with body mass index and is elevated in uncomplicated obesity. It is more severe when glucose tolerance becomes abnormal or diabetes is present. It is associated with impaired diastolic filling, even in seemingly asymptomatic obese volunteers. Because fatty heart can be readily prevented by lifestyle modification and pharmacologic interventions that reduce caloric intake and increase fatty acid oxidation, it seems important to recognize its existence so as to intervene as early as possible.
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Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
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Self-citationObesity and the risk of heart failure
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Mechanisms and consequences of activation of protein kinase B/Akt
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Lipotoxic heart disease in obese rats: Implications for human obesity
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Cited by
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436
Self-citationDiabetes and apoptosis: lipotoxicity
Kusminski, C. M., Shetty, S., Orci, L., Unger, R. H., & Scherer, P. E. (2009) · Apoptosis · doi:10.1007/s10495-009-0352-8 · Cited by 302
Self-citationRoutledge, C., Ostafin, B., Juhl, J., Sedikides, C., Cathey, C., & Liao, J. (2010) · Journal of Personality and Social Psychology · doi:10.1037/a0021431 · Cited by 227
Mathew, H., Farr, O. M., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2015.10.019 · Cited by 182
Postprandial metabolism of meal triglyceride in humans
Lambert, J. E., & Parks, E. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.01.006 · Cited by 182
Metadata
- Authors
- Szczepaniak, L. S., Victor, R. G., Orci, L., & Unger, R. H.
- Venue
- Circulation Research
- Published
- 2007-10-12
- Volume
- 101
- Issue
- 8
- Pages
- 759-767
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2129179042
- Cited by
- 257
- References
- 85
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Szczepaniak, L. S., Victor, R. G., Orci, L., & Unger, R. H. (2007). Forgotten but Not Gone: The Rediscovery of Fatty Heart, the Most Common Unrecognized Disease in America. Circulation Research. https://doi.org/10.1161/circresaha.107.160457
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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