Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1

Lu, Jonathan; Yang, Jun-Hai; Burns, Alan R.; Chen, Hsin-Hung; Tang, Daming; Walterscheid, Jeffrey P.; Suzuki, Shinichi; Yang, Chao-Yuh; Sawamura, Tatsuya; Chen, Chu-Huang

doi:10.1161/circresaha.108.190116

Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1

The lectin-like oxidized LDL receptor LOX-1 mediates endothelial cell (EC) uptake of experimentally prepared copper-oxidized LDL (oxLDL). To confirm the atherogenic role of this receptor cloned against copper-oxLDL, we examined whether it mediates EC uptake of L5, an electronegative LDL abundant …