The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Development of the Pacemaker Tissues of the Heart
Abstract
Pacemaker and conduction system myocytes play crucial roles in initiating and regulating the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging cause dysfunction of the pacemaker and conduction tissues, emphasizing the clinical necessity to understand the molecular and cellular mechanisms of their development and homeostasis. Although all cardiac myocytes of the developing heart initially possess pacemaker properties, the majority differentiates into working myocardium. Only small populations of embryonic myocytes will form the sinus node and the atrioventricular node and bundle. Recent efforts have revealed that the development of these nodal regions is achieved by highly localized suppression of working muscle differentiation, and have identified transcriptional repressors that mediate this process. This review will summarize and reflect new experimental findings on the cellular origin and the molecular control of differentiation and morphogenesis of the pacemaker tissues of the heart. It will also shed light on the etiology of inborn and acquired errors of nodal tissues.
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Cites
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Cited by
Protze, S. I., Liu, J., Nussinovitch, U., Ohana, L., Backx, P. H., Gepstein, L., & Keller, G. M. (2017) · Nature Biotechnology · doi:10.1038/nbt.3745 · Cited by 366
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18
Kapoor, N., Liang, W., Marbán, E., & Cho, H. C. (2013) · Nature Biotechnology · doi:10.1038/nbt.2465 · Cited by 321
The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life
Tan, C. M. J., & Lewandowski, A. J. (2020) · Fetal Diagnosis and Therapy · doi:10.1159/000501906 · Cited by 253
Multi-chamber cardioids unravel human heart development and cardiac defects
(2023) · doi:10.1016/j.cell.2023.10.030 · Cited by 205
Sartiani, L., Mannaioni, G., Masi, A., Novella Romanelli, M., & Cerbai, E. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014035 · Cited by 143
Metadata
- Authors
- Christoffels, V. M., Smits, G. J., Kispert, A., & Moorman, A. F. M.
- Venue
- Circulation Research
- Published
- 2010-02-05
- Volume
- 106
- Issue
- 2
- Pages
- 240-254
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2159459254
- Cited by
- 295
- References
- 111
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Christoffels, V. M., Smits, G. J., Kispert, A., & Moorman, A. F. M. (2010). Development of the Pacemaker Tissues of the Heart. Circulation Research. https://doi.org/10.1161/circresaha.109.205419
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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