The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
PGC-1 Coactivators in Cardiac Development and Disease
Open accessAbstract
The beating heart requires a constant flux of ATP to maintain contractile function, and there is increasing evidence that energetic defects contribute to the development of heart failure. The last 10 years have seen a resurgent interest in cardiac intermediary metabolism and a dramatic increase in our understanding of transcriptional networks that regulate cardiac energetics. The PPAR-γ coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological cues, as well as the roles they play in cardiac development and disease, are reviewed here.
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Cited by
Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F. H., & Hunter, T. (2016) · eLife · doi:10.7554/elife.13374 · Cited by 671
“At first glance, this was confusing, because overexpression of PGC-1a in cardiac cells triggers the upregula- tion of hundreds of genes in glycolysis, TCA and mitochondrial respiratory complexes (Rowe et al., 2010).”
BackgroundThe role of PGC‐1 coactivators in aging skeletal muscle and heart
Dillon, L. M., Rebelo, A. P., & Moraes, C. T. (2012) · IUBMB Life · doi:10.1002/iub.608 · Cited by 116
Testosterone replacement attenuates mitochondrial damage in a rat model of myocardial infarction
Wang, F., Yang, J., Sun, J., Dong, Y., Zhao, H., Shi, H., & Fu, L. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0638 · Cited by 41
Cellular Models of Aging and Senescence
Kim, B., Lee, D. I., Basisty, N., & Dai, D.-F. (2025) · Cells · doi:10.3390/cells14161278 · Cited by 16
Metadata
- Authors
- Rowe, G. C., Jiang, A., & Arany, Z.
- Venue
- Circulation Research
- Published
- 2010-10
- Volume
- 107
- Issue
- 7
- Pages
- 825-838
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2106136075
- Cited by
- 355
- References
- 196
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
