The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate
Open accessAbstract
Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is common in CKD patients and drives vascular calcification. In this article, we review the physiological regulatory mechanisms for Ca and P homeostasis and the basis for their dysregulation in CKD. In addition, we highlight recent findings indicating that elevated Ca and P have direct effects on vascular smooth muscle cells (VSMCs) that promote vascular calcification, including stimulation of osteogenic/chondrogenic differentiation, vesicle release, apoptosis, loss of inhibitors, and extracellular matrix degradation. These studies suggest a major role for elevated P in promoting osteogenic/chondrogenic differentiation of VSMC, whereas elevated Ca has a predominant role in promoting VSMC apoptosis and vesicle release. Furthermore, the effects of elevated Ca and P are synergistic, providing a major stimulus for vascular calcification in CKD. Unraveling the complex regulatory pathways that mediate the effects of both Ca and P on VSMCs will ultimately provide novel targets and therapies to limit the destructive effects of vascular calcification in CKD patients.
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Citations
Cites
Calcium metabolism in health and disease
Peacock, M. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05910809 · Cited by 886
Dhingra, R. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.9.879 · Cited by 861
Calcium and phosphate homeostasis: Concerted interplay of new regulators
Renkema, K. Y., Alexander, R. T., Bindels, R. J., & Hoenderop, J. G. (2008) · Annals of Medicine · doi:10.1080/07853890701689645 · Cited by 263
Tanikawa, T., Okada, Y., Tanikawa, R., & Tanaka, Y. (2009) · Journal of Vascular Research · doi:10.1159/000226225 · Cited by 191
Shao, J.-S., Cheng, S.-L., Charlton-Kachigian, N., Loewy, A. P., & Towler, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308825200 · Cited by 174
Osteoblast Autonomous Pi Regulation via Pit1 Plays a Role in Bone Mineralization
Yoshiko, Y., Candeliere, G. A., Maeda, N., & Aubin, J. E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00104-07 · Cited by 140
Cited by
Yahagi, K., Kolodgie, F. D., Lutter, C., Mori, H., Romero, M. E., Finn, A. V., & Virmani, R. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.306256 · Cited by 573
Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion
Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.305012 · Cited by 525
Self-citationYutzey, K. E., Demer, L. L., Body, S. C., Huggins, G. S., Towler, D. A., Giachelli, C. M., Hofmann-Bowman, M. A., Mortlock, D. P., Rogers, M. B., Sadeghi, M. M., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.302523 · Cited by 371
Self-citationPetsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.312787 · Cited by 341
The Role of Sclerostin in Bone and Ectopic Calcification
De Maré, A., D’Haese, P. C., & Verhulst, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093199 · Cited by 45
Metadata
- Authors
- Shanahan, C. M., Crouthamel, M. H., Kapustin, A., & Giachelli, C. M.
- Venue
- Circulation Research
- Published
- 2011-09-02
- Volume
- 109
- Issue
- 6
- Pages
- 697-711
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2108116509
- Cited by
- 958
- References
- 6
- FWCI
- 35.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shanahan, C. M., Crouthamel, M. H., Kapustin, A., & Giachelli, C. M. (2011). Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate. Circulation Research. https://doi.org/10.1161/circresaha.110.234914
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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