The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression
Abstract
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated with increased morbidity and mortality. The incidence of AF is expected to continue to rise with the aging of the population. AF is generally considered to be a progressive condition, occurring first in a paroxysmal form, then in persistent, and then long-standing persistent (chronic or permanent) forms. However, not all patients go through every phase, and the time spent in each can vary widely. Research over the past decades has identified a multitude of pathophysiological processes contributing to the initiation, maintenance, and progression of AF. However, many aspects of AF pathophysiology remain incompletely understood. In this review, we discuss the cellular and molecular electrophysiology of AF initiation, maintenance, and progression, predominantly based on recent data obtained in human tissue and animal models. The central role of Ca 2+ -handling abnormalities in both focal ectopic activity and AF substrate progression is discussed, along with the underlying molecular basis. We also deal with the ionic determinants that govern AF initiation and maintenance, as well as the structural remodeling that stabilizes AF-maintaining re-entrant mechanisms and finally makes the arrhythmia refractory to therapy. In addition, we highlight important gaps in our current understanding, particularly with respect to the translation of these concepts to the clinical setting. Ultimately, a comprehensive understanding of AF pathophysiology is expected to foster the development of improved pharmacological and nonpharmacological therapeutic approaches and to greatly improve clinical management.
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Cites
Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
Haïssaguerre, M., Jaïs, P., Shah, D. C., Takahashi, A., Hocini, M., Quiniou, G., Garrigue, S., Le Mouroux, A., Le Métayer, P., & Clémenty, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809033391003 · Cited by 7,975
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2012 focused update of the ESC Guidelines for the management of atrial fibrillation
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Atrial Fibrillation Begets Atrial Fibrillation: A Study in Awake Chronically Instrumented Goats
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2012 focused update of the ESC Guidelines for the management of atrial fibrillation
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Self-citationMicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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Electrical, contractile and structural remodeling during atrial fibrillation
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Self-citationColilla, S., Crow, A., Petkun, W., Singer, D. E., Simon, T., & Liu, X. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.05.063 · Cited by 1,321
Cited by
Calkins, H., Hindricks, G., Cappato, R., Kim, Y.-H., Saad, E. B., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,755
Self-citationGoette, A., Kalman, J. M., Aguinaga, L., Akar, J., Cabrera, J. A., Chen, S. A., Chugh, S. S., Corradi, D., D’Avila, A., Dobrev, D., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 771
Self-citationAtrial Fibrillation and Mechanisms of Stroke: Time for a New Model
Kamel, H., Okin, P. M., Elkind, M. S. V., & Iadecola, C. (2016) · Stroke · doi:10.1161/strokeaha.115.012004 · Cited by 627
Postoperative atrial fibrillation: mechanisms, manifestations and management
Dobrev, D., Aguilar, M., Heijman, J., Guichard, J.-B., & Nattel, S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0166-5 · Cited by 608
Self-citationInflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery
Zakkar, M., Ascione, R., James, A. F., Angelini, G. D., & Suleiman, M. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.009 · Cited by 274
Metadata
- Authors
- Heijman, J., Voigt, N., Nattel, S., & Dobrev, D.
- Venue
- Circulation Research
- Published
- 2014-04-25
- Volume
- 114
- Issue
- 9
- Pages
- 1483-1499
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2125693777
- Cited by
- 677
- References
- 163
- FWCI
- 34.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heijman, J., Voigt, N., Nattel, S., & Dobrev, D. (2014). Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression. Circulation Research. https://doi.org/10.1161/circresaha.114.302226
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
