The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Short-Term Disruption of Diurnal Rhythms After Murine Myocardial Infarction Adversely Affects Long-Term Myocardial Structure and Function
Abstract
Rationale: Patients in intensive care units are disconnected from their natural environment. Synchrony between environmental diurnal rhythms and intracellular circadian rhythms is essential for normal organ biology; disruption causes pathology. Whether disturbing rhythms after myocardial infarction (MI) exacerbates long-term myocardial dysfunction is not known. Objective: Short-term diurnal rhythm disruption immediately after MI impairs remodeling and adversely affects long-term cardiac structure and function in a murine model. Methods and Results: Mice were infarcted by left anterior descending coronary artery ligation (MI model) within a 3-hour time window, randomized to either a normal diurnal or disrupted environment for 5 days, and then maintained under normal diurnal conditions. Initial infarct size was identical. Short-term diurnal disruption adversely affected body metabolism and altered early innate immune responses. In the first 5 days, crucial for scar formation, there were significant differences in cardiac myeloperoxidase, cytokines, neutrophil, and macrophage infiltration. Homozygous clock mutant mice exhibited altered infiltration after MI, consistent with circadian mechanisms underlying innate immune responses crucial for scar formation. In the proliferative phase, 1 week after MI, this led to significantly less blood vessel formation in the infarct region of disrupted mice; by day 14, echocardiography showed increased left ventricular dilation and infarct expansion. These differences continued to evolve with worse cardiac structure and function by 8 weeks after MI. Conclusions: Diurnal rhythm disruption immediately after MI impaired healing and exacerbated maladaptive cardiac remodeling. These preclinical findings suggest that disrupted diurnal rhythms such as found in modern intensive care unit environments may adversely affect long-term patient outcome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For instance, recovery from experimentally induced myocardial ischemia is impaired in mice by rapidly shifting light/dark cycles, suggesting that sleep and circadian rhythm disruption that occurs in intensive care units may compromise recovery (145).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [145]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Pfeffer, M. A., & Braunwald, E. (1990) · Circulation · doi:10.1161/01.cir.81.4.1161 · Cited by 2,874
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632
Regulation of the Inflammatory Response in Cardiac Repair
Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,239
Inflammatory Cytokines and Postmyocardial Infarction Remodeling
Nian, M., Lee, P. C., Khaper, N., & Liu, P. J. (2004) · Circulation Research · doi:10.1161/01.res.0000130526.20854.fa · Cited by 1,031
Mullane, K., Kraemer, R. T., & Smith, B. (1985) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(85)90029-4 · Cited by 974
Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction
Nahrendorf, M., Pittet, M. J., & Świrski, F. K. (2010) · Circulation · doi:10.1161/circulationaha.109.916346 · Cited by 818
Ventricular Remodeling after Myocardial Infarction
Mitchell, G. F., Lamas, G. A., & Pfeffer, M. A. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2946-0_25 · Cited by 757
Gibbs, J. E., Blaikley, J., Beesley, S., Matthews, L. C., Simpson, K. D., Boyce, S., Farrow, S. N., Else, K. J., Singh, D., Ray, D. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106750109 · Cited by 692
Cited by
Sorted by citations
Items 101–122 of 122
Noor, K. M. K. M., Wyse, C. A., Roy, L. A., Biello, S. M., McCabe, C., & Dewar, D. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16671316 · Cited by 4
Molecular subtypes of ischemic heart disease based on circadian rhythm
Zhou, Z., Zhang, G., Wang, Z., Xu, Y., Qin, H., Zhang, H., Zhang, P., Li, Z., Xu, S., Tan, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65236-5 · Cited by 5
ATS Core Curriculum 2016: Part I. Adult Sleep Medicine
Balachandran, J. S., Thomson, C. C., Sumter, D. B., Shelgikar, A. V., Lachapelle, P., Pamidi, S., Fall, M., Lal, C., Baba, R. Y., Shah, N. A., et al. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201512-840cme · Cited by 3
Is the bedtime ingestion of hypertensive medications effective and safe?
Bowles, N. P., & Shea, S. A. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101511 · Cited by 3
The circadian clock regulates innate immunity and cardiovascular diseases
Qiu, D., Li, L., Yu, X., Xiao, Z., Chen, K., Wang, Z., & Wang, S. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178050 · Cited by 2
Récepteurs nucléaires et rythmes circadiens
Duez, H., & Pourcet, B. (2022) · médecine/sciences · doi:10.1051/medsci/2022102 · Cited by 2
Wang, B., Chen, J., Wang, L., Liu, Y., & Liu, M. (2025) · International Heart Journal · doi:10.1536/ihj.24-510 · Cited by 1
Twenty‐Four Hour Rhythms in Cardiovascular Physiology
Thomsen, M. B. (2025) · Acta Physiologica · doi:10.1111/apha.70116 · Cited by 1
Podobed, P. (2014) · The Atrium (University of Guelph)
Tsimakouridze, E. V. (2017) · The Atrium (University of Guelph)
Self-citationDisruption of the light/dark cycle and outcome after experimental stroke
Noor, K. M. K. M., & Mastura, K. (2017) · Enlighten: Theses (The University of Glasgow)
Circadian Medicine: Cannabinoid Chronotherapy for Treatment of Hypertension
Murray, A. (2020) · The Atrium (University of Guelph)
Circadian Regulation of Autophagy in the Heart Via the mTOR Pathway
Love, M., Rabinovich-Nikitin, I., & Kirshenbaum, L. A. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-78799-8_9
Through the multidimensional looking glass: Novel perspectives on heart failure
Crnko, S. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/919
Chronobiologie et implications en pathologie cardiovasculaire
Decoin, R., Butruille, L., Ducastel, S., Staels, B., & Montaigne, D. (2022) · La Presse Médicale Formation · doi:10.1016/j.lpmfor.2022.10.020
Artificial Light at Night Disrupts Pain Behavior and Cerebrovascular Structure in Mice
Bumgarner, J. R. (2023) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.12037
Circadian Regulation of Peripheral Inflammation
Tiwari, A., & Ch, R. (2024) · Progress in inflammation research · doi:10.1007/978-3-031-74744-1_2
Lin, J., Yao, H., Li, J., Tian, S., Li, X., & Hou, Q. (2023) · Figshare · doi:10.6084/m9.figshare.24531956
Pollock, D. M., Martino, T. A., Knutson, K. L., Panda, S., Chaix, A., Paul, K., Shimbo, D., & Gumz, M. L. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0000000000000198
Self-citationLuo, C., Li, T., Tak, J., DeBerge, M., Tsai, K., & Eltzschig, H. K. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01339-y
Metadata
- Authors
- Alibhai, F. J., Tsimakouridze, E. V., Chinnappareddy, N., Wright, D. C., Billia, F., O’Sullivan, M. L., Pyle, W. G., Sole, M. J., & Martino, T. A.
- Affiliations
- University Health Network (CA)
- ORCID
- Venue
- Circulation Research
- Published
- 2014-05-23
- Volume
- 114
- Issue
- 11
- Pages
- 1713-1722
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2129546872
- Semantic Scholar
- 52dc76bbff6a1eb6aeaa8f8ad67a1849f7a682fe
- Cited by
- 122
- References
- 54
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 18 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 5 · 2015: 10 · 2014: 6
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- IslandScholar (University of Prince Edward Island) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MOP119518)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- myocardial infarction, circadian rhythm disruption, diurnal cycle, cardiac remodeling, myocardial fibrosis, innate immune response, macrophage infiltration, neutrophils, myeloperoxidase, infarct healing, coronary artery ligation, ICU environment, left ventricular dilatation, infarct expansion, Clock mutant mice
- MeSH terms
- Animals, Circadian Rhythm, Coronary Vessels, Disease Models, Animal, Heart, Ligation, Male, Mice, Inbred C57BL, Myocardial Infarction, Myocardium, Time Factors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
