How mitochondrial dynamism orchestrates mitophagy
Open accessAbstract
Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-promoting proteins that mediate mitochondrial dynamism are highly expressed in, and essential to the normal functioning of, hearts. Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway. Based in part on recent findings from in vivo mouse models in which mitofusin-mediated mitochondrial fusion or dynamin-related protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propose several new concepts that may provide insight into the cardiac mitochondrial dynamism-mitophagy interactome.
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Mitophagy is intricately linked to mitochondrial dynamics.
“Mitophagy is intricately linked to mitochondrial dynamics [180,181,182].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [180]
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References 157 · Cited by 311
Research works printed but not linked: 1
- [87]Barker MG Walmsley RM Replicative ageing in the fission yeast Schizosaccharomyces pombe Yeast 1999 15 1511 1518 10514568
- Authors
- Shirihai, O. S., Song, M., & Dorn, G. W.
- Affiliations
- Boston University (US)
- Venue
- Circulation Research
- Published
- 2015-05-22
- Volume
- 116
- Issue
- 11
- Pages
- 1835-1849
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4443843
- OpenAlex
- W2126133274
- Cited by
- 311
- References
- 157
- Citations by year
- 2026: 13 · 2025: 28 · 2024: 29 · 2023: 26 · 2022: 38 · 2021: 30 · 2020: 35 · 2019: 23 · 2018: 33 · 2017: 29 · 2016: 18 · 2015: 9
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL087871, R01HL128071, HL128071, HL59888, R01HL059888)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074778, DK074778)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondrial dynamics, mitophagy, mitochondrial fission, mitochondrial fusion, cardiomyocytes, Parkin, mitofusins, Drp1, conditional knockout mouse model
- MeSH terms
- PTEN-Induced Putative Kinase, Animals, Humans, Mitochondria, Heart, Models, Biological, Protein Kinases, Signal Transduction, Dynamins, Ubiquitin-Protein Ligases, Mitochondrial Dynamics, Mitophagy
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