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Cited by 345Gut microbiota and healthOral microbiology and periodontitis researchNutritional Studies and Diet

Gut Microbiome Associates With Lifetime Cardiovascular Disease Risk Profile Among Bogalusa Heart Study Participants

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Kelly, Tanika N., Bazzano, Lydia A., Ajami, Nadim J., He, Hua, Zhao, Jinying, Petrosino, Joseph F., Correa, Adolfo, He, Jiang·2016·Circulation Research
DOI 10.1161/circresaha.116.309219PMC PMC5045790
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Abstract

Rationale: Few studies have systematically assessed the influence of gut microbiota on cardiovascular disease (CVD) risk. Objective: To examine the association between gut microbiota and lifetime CVD risk profile among 55 Bogalusa Heart Study participants with the highest and 57 with the lowest lifetime burdens of CVD risk factors. Methods and Results: 16S ribosomal RNA sequencing was conducted on microbial DNA extracted from stool samples of the Bogalusa Heart Study participants. α Diversity, including measures of richness and evenness, and individual genera were tested for associations with lifetime CVD risk profile. Multivariable regression techniques were used to adjust for age, sex, and race (model 1), along with body mass index (model 2) and both body mass index and diet (model 3). In model 1, odds ratios (95% confidence intervals) for each SD increase in richness, measured by the number of observed operational taxonomic units, Chao 1 index, and abundance-based coverage estimator, were 0.62 (0.39–0.99), 0.61 (0.38–0.98), and 0.63 (0.39–0.99), respectively. Associations were consistent in models 2 and 3. Four genera were enriched among those with high versus low CVD risk profile in all models. Model 1 P values were 2.12×10 −3 , 7.95×10 −5 , 4.39×10 −4 , and 1.51×10 −4 for Prevotella 2, Prevotella 7 , Tyzzerella , and Tyzzerella 4 , respectively. Two genera were depleted among those with high versus low CVD risk profile in all models. Model 1 P values were 2.96×10 −6 and 1.82×10 −4 for Alloprevotella and Catenibacterium , respectively. Conclusions: The current study identified associations of overall microbial richness and 6 microbial genera with lifetime CVD risk.

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  • Tyzzerella can form spores and is associated with coronary heart disease.

    “Tyzzerella can form spores and is associated with coronary heart disease (Kelly et al., 2016).”

    From <i>Akkermansia muciniphila</i> alleviates <scp>high‐fat‐diet</scp> ‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids (2023) · cites this paper as Kelly et al., 2016

    The Results and Discussion (page numbers unavailable) report that Tyzzerella was enriched among Bogalusa Heart Study participants with a high lifetime cardiovascular disease risk profile. They do not establish an association with diagnosed coronary heart disease or say that Tyzzerella can form spores; searches for spore formation and coronary heart disease found no supporting passage. (LLM, conf=0.90)

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Authors
Kelly, T. N., Bazzano, L. A., Ajami, N. J., He, H., Zhao, J., Petrosino, J. F., Correa, A., & He, J.
Affiliations
Tulane University (US)
ORCID
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-09-30
Volume
119
Issue
8
Pages
956-964
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/circresaha.116.309219
PMC
PMC5045790
OpenAlex
W2506779819
Cited by
345
References
41
Citations by year
2026: 17 · 2025: 28 · 2024: 34 · 2023: 36 · 2022: 65 · 2021: 47 · 2020: 40 · 2019: 29 · 2018: 30 · 2017: 17 · 2016: 2
FWCI
13.52
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (RF1AG041200, R21AG051914, R01AG041200)
  • National Institute of General Medical Sciences (P20GM109036)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
gut microbiota, cardiovascular risk, lifetime cardiovascular risk, microbial diversity, Prevotella, Tyzzerella, Alloprevotella, Catenibacterium, Bogalusa Heart Study, body mass index, diet, 16S rRNA gene sequencing
MeSH terms
Gastrointestinal Microbiome, Adolescent, Adult, Cardiovascular Diseases, Child, Child, Preschool, Female, Humans, Longitudinal Studies, Louisiana, Male, Middle Aged, Risk Factors, RNA, Ribosomal, 16S, Cohort Studies, Young Adult

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