Cardiac Nonmyocytes in the Hub of Cardiac Hypertrophy
Open accessAbstract
Cardiac hypertrophy is characterized by complex multicellular alterations, such as cardiomyocyte growth, angiogenesis, fibrosis, and inflammation. The heart consists of myocytes and nonmyocytes, such as fibroblasts, vascular cells, and blood cells, and these cells communicate with each other directly or indirectly via a variety of autocrine or paracrine mediators. Accumulating evidence has suggested that nonmyocytes actively participate in the development of cardiac hypertrophy. In this review, recent progress in our understanding of the importance of nonmyocytes as a hub for induction of cardiac hypertrophy is summarized with an emphasis of the contribution of noncontact communication mediated by diffusible factors between cardiomyocytes and nonmyocytes in the heart.
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Advanced signs of cardiovascular aging such as tissue remodeling and cardiac hypertrophy are often preceded and may be initiated by malfunctioning aged endothelia.
“More recent work has also shown that advanced signs of cardiovascular aging such as tissue remodeling and cardiac hypertrophy are often preceded and may be initiated by the malfunctioning of aged endothelia50–52.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [52]
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References 115 · Cited by 171
- Authors
- Kamo, T., Akazawa, H., & Komuro, I.
- Affiliations
- Japan Science and Technology Agency (JP)
- Venue
- Circulation Research
- Published
- 2015-06-19
- Volume
- 117
- Issue
- 1
- Pages
- 89-98
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2272839530
- Cited by
- 171
- References
- 115
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 23 · 2023: 14 · 2022: 9 · 2021: 17 · 2020: 18 · 2019: 20 · 2018: 23 · 2017: 11 · 2016: 14 · 2015: 4
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Circulation Research
- Funders
- Japan Society for the Promotion of Science (26253049, 26670395)
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- cardiac hypertrophy, paracrine signaling, autocrine signaling, cardiac fibroblasts, vascular cells, cardiomyocyte growth, myocardial fibrosis, angiogenesis, inflammation, diffusible factors
- MeSH terms
- Animals, Blood Cells, Fibroblasts, Cardiomegaly, Humans, Macrophages, Mast Cells, Myocardium, Cell Lineage, Endothelin-1, Autocrine Communication, Paracrine Communication, Myocytes, Cardiac, MicroRNAs, Intercellular Signaling Peptides and Proteins, Endothelial Cells, Natriuretic Peptides, Mice
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