The DOI matches its Crossref record, with a small difference in title or year; 251 of the 252 references it cites were found in a registry or an index.
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy
Open accessAbstract
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetrical with the most severe hypertrophy involving the basal interventricular septum. Left ventricular outflow tract obstruction is present at rest in about one third of the patients and can be provoked in another third. The histological features of HCM include myocyte hypertrophy and disarray, as well as interstitial fibrosis. The hypertrophy is also frequently associated with left ventricular diastolic dysfunction. In the majority of patients, HCM has a relatively benign course. However, HCM is also an important cause of sudden cardiac death, particularly in adolescents and young adults. Nonsustained ventricular tachycardia, syncope, a family history of sudden cardiac death, and severe cardiac hypertrophy are major risk factors for sudden cardiac death. This complication can usually be averted by implantation of a cardioverter-defibrillator in appropriate high-risk patients. Atrial fibrillation is also a common complication and is not well tolerated. Mutations in over a dozen genes encoding sarcomere-associated proteins cause HCM. MYH7 and MYBPC3 , encoding β-myosin heavy chain and myosin-binding protein C, respectively, are the 2 most common genes involved, together accounting for ≈50% of the HCM families. In ≈40% of HCM patients, the causal genes remain to be identified. Mutations in genes responsible for storage diseases also cause a phenotype resembling HCM (genocopy or phenocopy). The routine applications of genetic testing and preclinical identification of family members represents an important advance. The genetic discoveries have enhanced understanding of the molecular pathogenesis of HCM and have stimulated efforts designed to identify new therapeutic agents.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This clinical variability can, in part, be explained by the influence of modifiable cardiometabolic risk factors, such as obesity, diabetes, and hypertension [6].”
From Association of GLP-1 receptor agonist use with cardiovascular outcomes in patients with non-obstructive hypertrophic cardiomyopathy (2026) · cites this paper as [6]
Experimental — accuracy not yet measuredIn the citing paper
“Hypertrophic cardiomyopathy (HCM) is characterized by cardiac hypertrophy, a non-dilated left ventricle (LV), and a normal or increased EF.”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247
A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Authors/Task Force members, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu284 · Cited by 4,332
Prevalence of Hypertrophic Cardiomyopathy in a General Population of Young Adults
Maron, B. J., Gardin, J. M., Flack, J. M., Gidding, S. S., Kurosaki, T., & Bild, D. E. (1995) · Circulation · doi:10.1161/01.cir.92.4.785 · Cited by 2,274
Sudden Deaths in Young Competitive Athletes
Maron, B. J., Doerer, J. J., Haas, T. S., Tierney, D. M., & Mueller, F. O. (2009) · Circulation · doi:10.1161/circulationaha.108.804617 · Cited by 2,099
Sudden Death in Young Competitive Athletes: Clinical, Demographic, and Pathological Profiles
Maron, B. J. (1996) · JAMA · doi:10.1001/jama.1996.03540030033028 · Cited by 1,693
New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy
Semsarian, C., Ingles, J., Maron, M. S., & Maron, B. J. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.019 · Cited by 1,405
Geisterfer-Lowrance, A. A. T., Kass, S., Tanigawa, G., Vosberg, H.-P., McKenna, W., Seidman, C. E., & Seidman, J. G. (1990) · Cell · doi:10.1016/0092-8674(90)90274-i · Cited by 1,380
Richard, P., Charron, P., Carrier, L., Ledeuil, C., Cheav, T., Pichereau, C., Benaiche, A., Isnard, R., Dubourg, O., Burban, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000066323.15244.54 · Cited by 1,276
O'Mahony, C., Jichi, F., Pavlou, M., Monserrat, L., Anastasakis, A., Rapezzi, C., Biagini, E., Gimeno, J. R., Limongelli, G., McKenna, W. J., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/eht439 · Cited by 1,251
Research works printed but not linked: 2
- 10.1161/01.CIR.104.3.317 · DOI
- BROCK R. Functional obstruction of the left ventricle (acquired aortic subvalvar stenosis). Guys Hosp Rep. 1959;108:126–143.
Cited by
Sorted by citations
Items 701–800 of 1,001
Liu, D., Luo, H., Feng, C., Lian, Y., Pan, Z., Guo, X., & Yang, Q. (2024) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2024.110311 · Cited by 4
Cai, S., Jin, T., Liu, M., & Dai, Q. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1546865 · Cited by 4
The Role of Cardiovascular Magnetic Resonance Imaging in Athletic Individuals—A Narrative Review
Grech, N., & Abela, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103576 · Cited by 6
Otmani, Z., Abdrabou, N., Elsayed, H. A., Yassin, M. N. A., Abouzid, M., Hindawi, M. D., & Awad, A. K. (2025) · Indian Heart Journal · doi:10.1016/j.ihj.2025.05.011 · Cited by 4
Role of Genetics in Early-Onset Cardiovascular Disease
van de Meer, M. G., van de Meer, M. G., Mumtaz, M. A., & Jawed, U. (2025) · Cureus · doi:10.7759/cureus.85988 · Cited by 4
Ma, L., Lu, B., Si, Y., Dai, L., Tan, M., Liu, W., Sun, D., Shu, J., Chen, C., Xiang, Q., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110421 · Cited by 5
Wang, W., Cathcart, B., Nguyen, Q. D., Lao, L. Q., Bryans, A., Coleman, S. E., Rouhi, L., Gurha, P., & Marian, A. J. (2025) · JCI Insight · doi:10.1172/jci.insight.192283 · Cited by 4
Self-citationRedefining Left Ventricular Systolic Dysfunction in Hypertrophic Cardiomyopathy
Kwak, S., & Kim, H. (2025) · Heart Failure Clinics · doi:10.1016/j.hfc.2025.06.002 · Cited by 4
Metabolomics in cardiovascular diseases: from prevention strategies to domain-specific applications
Zhao, Q., Pang, Y. Y., Lim, R. L., Tham, W. K., & Choi, H. (2025) · Expert Review of Proteomics · doi:10.1080/14789450.2025.2606050 · Cited by 5
Sun, J., Zhou, D., & Cheng, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010095 · Cited by 4
Faggiano, A., Casas, G., Gonzalez‐Santorum, F., Ingla, A. S., Brusamolino, M., Tomasino, C., Miccoli, D., Fernandez, J. R., Ceballos, M. S., Escribano, P. E., et al. (2026) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeag049 · Cited by 4
mRNA medicine for cardiovascular disease
Zhou, Z., Chen, W., Yu, H., Tabas, I. A., Foo, R., & Tao, W. (2026) · Nature Cardiovascular Research · doi:10.1038/s44161-026-00804-8 · Cited by 6
Case Report: Identification of Mutations in LAMP2 in Two Chinese Infants With Danon Disease
Zhang, L., Yang, F., Chen, M., Zhou, M. D., Qian, T., Mujtaba, M. O., Mohammed, A. H., Yin, J., Cheng, X., Chen, J., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.589838 · Cited by 4
Ariss, R. W., Minhas, A. M. K., Nazir, S., Patel, M. M., Nesheiwat, Z., Mhanna, M., Kayani, W. T., Moukarbel, G. V., Nasir, K., & Jneid, H. M. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101102 · Cited by 4
Incognito, C., Hedley, J., Posadas, K. T., Wang, X., & Desai, M. Y. (2023) · Texas Heart Institute Journal · doi:10.14503/thij-21-7730 · Cited by 4
Zhang, H., Yu, C., Cheng, Y., Chen, Z., Chen, M., He, W., Jin, Z., Cai, S., & Lijuan, Y. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s413136 · Cited by 4
Abulaiti, A., Zhang, Q., Huang, H., Ding, S., Shayiti, M., Wang, S., Wang, Y., & Jia, W. (2023) · Journal of Interventional Cardiology · doi:10.1155/2023/4611602 · Cited by 4
Meng, X., Gao, J. L., Zhang, K., Jun, W., Wang, J., Wang, X., Wang, Y.-G.-S., Zheng, J., Liu, Y.-P., Song, J., et al. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01084-z · Cited by 4
Whole-Exome Sequencing Reveals Mutational Signature of Hypertrophic Cardiomyopathy
Wang, X., Fang, Y., & Yu, B.-R. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s422598 · Cited by 4
Chen, C., Liu, Y., Yang, S., Chen, M., & Liao, J. (2024) · Medicine · doi:10.1097/md.0000000000037969 · Cited by 5
Rivas, V. N., Crofton, A. E., Jauregui, C. E., Wouters, J. R., Yang, B. S., Wittenburg, L. A., Kaplan, J. L., Hwee, D. T., Murphy, A. N., Morgan, B. P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-62840-3 · Cited by 4
Shifting paradigms in hypertrophic cardiomyopathy: the role of exercise in disease management
Yamagata, L. M., Yamagata, K., Borg, A., & Abela, M. (2024) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2024.07.001 · Cited by 4
Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor
Kooiker, K. B., Gan, Q.-F., Yu, M., Sa, N., Mohran, S. E., Cheng, Y., Flint, G. V., Neys, S., Gao, C., Nissen, D. L., et al. (2024) · The Journal of General Physiology · doi:10.1085/jgp.202313503 · Cited by 4
Todurov, M. B., Todurov, B. M., Miriniuk, I. V., Zelenchuk, O. V., Hohlov, A. V., Stan, M. V., & Sudakevych, S. M. (2023) · Azerbajdžanskij medicinskij žurnal · doi:10.34921/amj.2023.2.025 · Cited by 4
Hagège, A. A., Puscas, T., Hachmi, M. E., Parodi, A., Bacher, A., Funalot, B., Wahbi, K., Jeunemaı̂tre, X., Damy, T., & Billon, C. (2024) · International Journal of Cardiology · doi:10.1016/j.ijcard.2024.132542 · Cited by 4
Diretriz Brasileira de Ergometria em Crianças e Adolescentes – 2024
de Carvalho, T., de Freitas, O. G. A., Chalela, W. A., Hossri, C. A. C., Milani, M., Buglia, S., Falcão, A. M. G. M., Costa, R. V. C., Ritt, L. E. F., Pfeiffer, M. E. T., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240525 · Cited by 4
Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review
Gill, R. S., Siddiqui, A. K., Yee, B., Dicaro, M. V., Houshmand, N., & Tak, T. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11090290 · Cited by 7
Austrian consensus statement on the diagnosis and management of hypertrophic cardiomyopathy
Verheyen, N., Auer, J., Bonaros, N. E., Buchacher, T., Dalos, D., Grimm, M. F., Mayr, A., Rab, A., Reinstadler, S. J., Scherr, D., et al. (2024) · Wiener klinische Wochenschrift · doi:10.1007/s00508-024-02442-1 · Cited by 4
Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cell-Based Models
Wang, B. (2024) · Life · doi:10.3390/life14111370 · Cited by 4
Calore, C., Mangia, M., Basso, C., Corrado, D., & Thiene, G. (2025) · Genes · doi:10.3390/genes16010074 · Cited by 5
Structural and Functional Characterization of the Aorta in Hypertrophic Obstructive Cardiomyopathy
Ibrahim, A. M., Latif, N., Roshdy, M., Sarathchandra, P., Hosny, M., Elsawy, A., Hekal, S., Attia, A., Elmozy, W., Elaithy, A., et al. (2025) · Circulation Heart Failure · doi:10.1161/circheartfailure.124.012384 · Cited by 4
Burford, E., Kasolo, Y., Draper, J., Sheikh, N., Carr‐White, G., de Marvao, A., Dungu, J. N., Bastiaenen, R., & Cooper, R. M. (2025) · Open Heart · doi:10.1136/openhrt-2025-003218 · Cited by 4
Villa, R. B., Escobar-López, L., Larena, D. V., Salazar‐Mendiguchía, J., Echeto, A., Hernández, I., Rebollo-Gómez, E., & Gimeno, J. R. (2025) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2025.04.004 · Cited by 4
Ultrasound Imaging of Cardiac Fiber Orientation: What are We Looking at?
Ramalli, A., Santos, P., & D’hooge, J. (2018) · IEEE International Ultrasonics Symposium · doi:10.1109/ultsym.2018.8580100 · Cited by 4
Zhou, Y., Yu, M., Yuan, J., Liu, S., Hu, F., Yang, Z., Cui, J., & Qiao, S. (2020) · Heart and Vessels · doi:10.1007/s00380-019-01549-0 · Cited by 4
Scleraxis as a prognostic marker of myocardial fibrosis in hypertrophic cardiomyopathy (SPARC) study
Zhu, A., Bews, H. J., Cheung, D. Y. C., Nagalingam, R. S., Mittal, I., Goyal, V., Asselin, C. Y., Kirkpatrick, I. D. C., Czubryt, M. P., & Jassal, D. S. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0636 · Cited by 4
Zhou, Y., Yu, M., Yuan, J., Hu, F., Liu, S., Yang, Z., Cui, J., & Qiao, S. (2020) · Cardiology · doi:10.1159/000505680 · Cited by 4
Impact of body mass index on left atrial dimension in HOCM patients
Zhou, Y., Yu, M., Cui, J., Liu, S., Yuan, J., & Qiao, S. (2021) · Open Medicine · doi:10.1515/med-2021-0224 · Cited by 4
Park, J., Lee, J. M., & Cho, J. S. (2021) · Medicina · doi:10.3390/medicina57030281 · Cited by 4
Wood, K., Ellingford, J. M., Eden, J., Thomas, H. B., O’Keefe, R. T., Hopton, C., & Newman, W. G. (2021) · Cardiogenetics · doi:10.3390/cardiogenetics11020009 · Cited by 4
Dong, X., Beijing-China, Zhang, D., Qu, Y., Xu, M., Zhao, L. Y., Liu, Y., & Zhou, X. (2021) · The Anatolian Journal of Cardiology · doi:10.5152/anatoljcardiol.2021.98537 · Cited by 4
Addis, D. R., & Townsley, M. M. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2021.07.024 · Cited by 4
Zhao, S. R., Shen, M., Lee, C., Zha, Y., Guevara, J. V., Wheeler, M. T., & Wu, J. C. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102597 · Cited by 4
Batzner, A., & Seggewiß, H. (2020) · Herz · doi:10.1007/s00059-020-04899-y · Cited by 4
Bilgic, D. G. (2022) · Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi · doi:10.34087/cbusbed.1052808 · Cited by 4
Xia, Y., Hu, J., Li, X., Zheng, S., Wang, G., Tan, S., Zou, Z., Ling, Q., Yang, F., & Fan, X. (2022) · Journal of Visualized Experiments · doi:10.3791/63949 · Cited by 4
Hypertrophic cardiomyopathy: an up-to-date snapshot of the clinical drug development pipeline
Tamargo, J. L., Tamargo, M., & Caballero, R. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2113374 · Cited by 4
Inherited cardiomyopathies: how nurses can facilitate holistic care for patients and their families
Martin, L., Mason, S., Kirkby, C., Kearl, F., Hargrave, J., Partridge, J., Taylor, J. S., Bueser, T. ‘., & Cowley, B. (2023) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2022.0107 · Cited by 4
Joseph, A., Hernandez, N. B., Davies, R. R., & Tan, W. (2023) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/21501351231166661 · Cited by 4
Identification of a Novel Splicing-Altering LAMP2 Variant in a Chinese Family with Danon Disease
Fu, D., Wang, S., Luo, Y., Wu, S., & Peng, D. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14417 · Cited by 4
Borrelli, F., Lombardi, R., Canciello, G., Frisso, G., Todde, G., Esposito, G., & Losi, M. A. (2023) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-023-10441-2 · Cited by 4
Li, B., Chen, L., Zheng, M., Yan, P., Wang, L., Feng, S., Yin, W., Zhang, K., Zhang, S., Chen, X., et al. (2023) · International Heart Journal · doi:10.1536/ihj.22-661 · Cited by 4
Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
Sen-Martín, L., Fernández‐Trasancos, Á., López-Unzu, M. Á., Pathak, D., Ferrarini, A., Labrador-Cantarero, V., Sánchez-Ortiz, D., Pricolo, M. R., Vicente, N., Velázquez-Carreras, D., et al. (2026) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2025.100517 · Cited by 4
Wu, X., Li, Y., Wang, Y., Zhang, M., Zhu, W., Cai, Q., Jiang, W., Sun, L., Ding, X., Ye, X., et al. (2019) · International journal of cardiac imaging · doi:10.1007/s10554-019-01530-y · Cited by 4
MYH7 Gene-Related Mutation p.V878L Identified in a Chinese Family with Hypertrophic Cardiomyopathy
Du, Y., Wang, Y., Han, X., Feng, Z., & Ma, A. (2019) · International Heart Journal · doi:10.1536/ihj.19-146 · Cited by 4
Ren, M., Chai, X., Li, L., Wang, X., & Yin, C. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1150 · Cited by 4
Thirty Controversies and Considerations in Hypertrophic Cardiomyopathy
Masri, A., Nazer, B., Al‐Rashdan, L., Mannello, M., Fischer, K. L., Akhavein, R., Divanji, P., Song, H. K., & Heitner, S. B. (2020) · Structural Heart · doi:10.1080/24748706.2020.1844926 · Cited by 4
An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
Esfahani, P. H., & Knöll, R. (2020) · Journal of Visualized Experiments · doi:10.3791/61577 · Cited by 4
Masuyama, K., Higo, T., Lee, J., Matsuura, R., Jones, I., Bakal, C., Higo, S., Morimoto, S., Miyagawa, S., Sawa, Y., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94100-z · Cited by 4
Delayed Diagnosis of Danon Disease in Patients Presenting With Isolated Cardiomyopathy
Demirdas, S., van Slegtenhorst, M. A., Verdijk, R. M., Lee, M., van den Hout, H. M. P., Wessels, M. W., Frohn-Mulder, I. M. E., Gardeitchik, T., van der Ploeg, A. T., & Schaaf, G. (2019) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.118.002395 · Cited by 4
Ioakeimidis, N. S., Pitsis, A. A., Ntelios, D., Zegkos, T., Kelpis, T. G., Papamitsou, T., Parcharidou, D. G., Efthimiadis, G. K., & Meditskou, S. (2021) · PubMed · doi:10.14670/hh-18-369 · Cited by 4
Burghardt, T. P. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00056-x · Cited by 4
Suay‐Corredera, C., & Alegre‐Cebollada, J. (2021) · Genetics in Medicine · doi:10.1038/s41436-021-01235-5 · Cited by 4
Danter, W. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.18.549304 · Cited by 4
Inherited arrhythmias and gene therapy: Are there any ethical considerations to take into account?
Spartalis, Μ., Spartalis, E. D., & Siasos, G. (2023) · World Journal of Cardiology · doi:10.4330/wjc.v15.i12.623 · Cited by 4
Du, J., Sudlow, L. C., Biswas, H., Mitchell, J. D., Mollah, S. A., & Berezin, M. Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.11.579390 · Cited by 4
Przytuła, N., Dziewięcka, E. M., Winiarczyk, M., Graczyk, K., Stępień, A., & Rubiś, P. (2024) · World Journal of Cardiology · doi:10.4330/wjc.v16.i9.496 · Cited by 4
Abi-Gerges, N., McMahon, C., Vargas, H., Sager, P., Chui, R., Stevens, D., Davila, J., Schaub, J. R., Wu, J. C., del Rio, C., et al. (2019) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2019.106582 · Cited by 3
Li, G., Lin, D., Fan, X., & Peng, B. (2024) · Cardiology Research and Practice · doi:10.1155/2024/4639334 · Cited by 3
Guo, X., Huang, M., Song, C., Nie, C., Zheng, X., Zhou, Z., Wang, S., & Huang, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34727 · Cited by 3
Identification and validation of autophagy‑related genes in hypertrophic cardiomyopathy
Qiu, R., Zhao, S.-T., Li, Z., Zeng, R.-Y., Qiu, Z.-C., Peng, H.-Z., Xu, Z., Zhou, L.-F., Lai, S., & Wan, L. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12729 · Cited by 3
Jager, J., Ribeiro, M., Furtado, M., Carvalho, T., Syrris, P., Lopes, L. R., Elliot, P. M., Cabral, J. M. S., Carmo‐Fonseca, M., da Rocha, S. T., et al. (2024) · Stem Cell Research · doi:10.1016/j.scr.2024.103582 · Cited by 3
In-hospital mortality and risk factors in critically ill patients with hypertrophic cardiomyopathy
Ma, Z., & Shirani, J. (2025) · Journal of Cardiology · doi:10.1016/j.jjcc.2025.01.003 · Cited by 3
Copeland, K. M., Chen, H., Chintapula, U. K., Almasian, M., Chung, D. K., Taylor, A. M., Ding, Y., Sharma, G., Jessen, M. E., Hong, Y., et al. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1620594 · Cited by 3
Unveiling the complexity of nonobstructive hypertrophic cardiomyopathy
Ordine, L., Polizzi, R., Canciello, G., Borrelli, F., Napoli, S., Moscano, L., Napolitano, B., Martorano, R., Spinelli, A. M., Lombardi, R., et al. (2025) · Heart Failure Reviews · doi:10.1007/s10741-025-10535-w · Cited by 3
Ibrahim, A. M., Elfawy, H. A., Terracciano, C. M., & Yacoub, M. H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1641584 · Cited by 3
Hypertrophic Cardiomyopathy: Current Perspectives
Patel, D., Bhargav, R., Mousa, A., & Bokhari, S. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm42824 · Cited by 3
LARP1 acts as a key mediator in preventing angiotensin II-induced cardiac dysfunction and fibrosis
Zheng, H., & Yang, C. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01481-z · Cited by 3
Beta blockers and hypertrophic obstructive cardiomyopathy: a systematic review and meta-analysis
Smith, A. J., Cromie, A. M. M., Bowles, L., Anderson, T., Panchal, J., & Walters, B. (2025) · Open Heart · doi:10.1136/openhrt-2025-003460 · Cited by 3
Mechanisms and Therapies of Hypertrophic Cardiomyopathy
Pietsch, N., Singh, S. R., & Carrier, L. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042224-093244 · Cited by 3
Mechanisms of metabolic transition in hypertrophic cardiomyopathy
Tan, C., Guo, Z., Zhou, J., & Yuan, W. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1700313 · Cited by 3
Nogueira-Garcia, B., Pinheiro, D., Gregório, C., Caldeira, D., Pinto, F. J., & Brito, D. A. (2025) · Journal of Cardiology · doi:10.1016/j.jjcc.2025.12.007 · Cited by 3
GSDME in cardiovascular diseases: research system and contemporary progress
Yang, Z., Luo, Z., Zhang, H., Zong, J., Huang, P., Niu, Y., Zhou, C., Wang, S., & Zhang, D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1683116 · Cited by 3
Molecular Pathology of Cardiomyopathies: Bridging Morphology, Genomics, and Clinical Phenotypes
Marzullo, A., & Salzillo, C. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48010060 · Cited by 3
Cardio-Vascular Extracellular Matrix: The Unmet Enigma
PARASKEVAIDIS, I. A., Tsougos, E., & Kourek, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010544 · Cited by 5
Mahmoud, A. K., Awad, K., Sheashaa, H., Kandil, O., Farina, J. M., Ibrahim, R., Abdelnabi, M., Allam, M., Mital, R., Shipman, J., et al. (2026) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcag051 · Cited by 3
Couto, J., & Martins, E. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144706 · Cited by 3
Wang, H., Bo, K., Gao, Y., Zhou, Z. X., Gao, X., Sun, Z., & Xu, L. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-23-466 · Cited by 3
Derda, A. A., Abelmann, M., Sieweke, J., Waleczek, F. J. G., Weber, N., Zehrfeld, N., Bär, C., Duncker, D., Bavendiek, U., Berliner, D., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-54153-2 · Cited by 3
Fu, D.-S., Adili, A., Chen, X., Li, J.-Z., & Muheremu, A. (2024) · SLAS TECHNOLOGY · doi:10.1016/j.slast.2024.100166 · Cited by 3
Heart Physiology and Heart Disease
Okwose, N. C., Charman, S. J., Fuller, A. S., MacGowan, G., Filipović, N., & Jakovljević, D. G. (2024) · Springer eBooks · doi:10.1007/978-3-031-60044-9_3 · Cited by 4
Guelfi, G., Venanzi, N., Capaccia, C., Stefanetti, V., Brachelente, C., Sforna, M., Porciello, F., & Lepri, E. (2024) · International Journal of Experimental Pathology · doi:10.1111/iep.12514 · Cited by 3
Ji, F., Yu, X., Sheng, W., Zhang, W., Wei, Y., Ji, X., Shan, Z., & Qi, L. (2024) · Heart & Lung · doi:10.1016/j.hrtlng.2024.10.006 · Cited by 3
Wang, C., Guo, W., Duan, H., Qin, J., Wang, F., He, T., Gao, L., Han, Z., Zhang, R., & Wu, L. (2024) · Echocardiography · doi:10.1111/echo.15930 · Cited by 3
Three Novel Pathogenic Variants in Unrelated Vietnamese Patients with Cardiomyopathy
Tran, D. D., Lien, N. T. K., Tung, N. V., Hựu, N. C., Nguyen, P. T., Tien, D. A., Thu, D. T. H., Huy, B. Q., Oanh, T. T. K., Lien, N. T. P., et al. (2024) · Diagnostics · doi:10.3390/diagnostics14232709 · Cited by 3
Sarwer, K., Lashari, S., Rafaqat, N., Maher, Raheem, A., Rehman, M. U., & Abbas, S. M. I. (2024) · The Egyptian Heart Journal · doi:10.1186/s43044-024-00587-y · Cited by 4
Exosome-Derived microRNAs in Hypertrophic Cardiomyopathy
Wang, B. (2024) · Cardiogenetics · doi:10.3390/cardiogenetics14040019 · Cited by 3
Abunada, A., Shah, M., Kumar, A., Mir, S. L., Kumar, D., Ahmed, S., Tanzeel, M., Kumar, V., Meghjiani, A., Siddiqui, M. B. A., et al. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1477487 · Cited by 3
Cardiac structural and molecular alterations in rodent models of temporal lobe epilepsy
Liu, Z., Sivathamboo, S., Thergarajan, P., Gomes, F. M. M., Ali, I. Y., Powell, K. L., Perucca, P., Jones, N. C., O'Brien, T. J., & Casillas-Espinosa, P. M. (2025) · Epilepsia Open · doi:10.1002/epi4.70032 · Cited by 3
Accelerometry-defined physical activity and quality of life in hypertrophic cardiomyopathy
Schoonvelde, S. A. C., Zwetsloot, P.-P. M., Hirsch, A., Schinkel, A. F. L., Knackstedt, C., Germans, T., van Slegtenhorst, M. A., Verhagen, J. M. A., de Boer, R. A., & Michels, M. (2025) · Heart · doi:10.1136/heartjnl-2025-326217 · Cited by 3
Metadata
- Authors
- Marian, A. J., & Braunwald, E.
- Affiliations
- Brigham and Women's Hospital (US)
- From the Center for Cardiovascular Genetics, Institute of Molecular Medicine, Department of Medicine, University of Texas Health Sciences Center at Houston (A.J.M.); Texas Heart Institute, Houston (A.J.M.); and TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (E.B.).
- ORCID
- Marian, Ali J.
- Venue
- Circulation Research
- Published
- 2017-09-15
- Volume
- 121
- Issue
- 7
- Pages
- 749-770
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC5654557
- OpenAlex
- W2756203218
- Cited by
- 1,403
- References
- 252
- Citations by year
- 2026: 175 · 2025: 226 · 2024: 219 · 2023: 199 · 2022: 153 · 2021: 174 · 2020: 103 · 2019: 83 · 2018: 61 · 2017: 6
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL088498, R01HL132401)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- hypertrophic cardiomyopathy, left ventricular hypertrophy, left ventricular outflow tract obstruction, sudden cardiac death, non-sustained ventricular tachycardia, syncope, cardioverter-defibrillator implantation, atrial fibrillation, sarcomere gene mutations, MYH7, MYBPC3, genetic testing, phenocopy, storage diseases, left ventricular diastolic dysfunction, interstitial fibrosis, molecular pathogenesis
- MeSH terms
- Animals, Biopsy, Cardiomyopathy, Dilated, DNA Mutational Analysis, Genetic Markers, Humans, Mutation, Myocardium, Phenotype, Predictive Value of Tests, Prognosis, Risk Factors, Ventricular Function, Left, Risk Assessment, Genetic Predisposition to Disease, Molecular Diagnostic Techniques, Cardiac Imaging Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
