RNA-Sequencing Reveals a Distinct Transcriptomic Signature for Giant Cell Myocarditis and Identifies Novel Druggable Targets
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In these tissues, genes related to cardiac contraction, conduction, and homeostasis are downregulated.
“with downregulated genes related to cardiac contraction, conduction, and homeostasis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [188]
In biopsy or explant tissues of patients with giant cell myocarditis, genes related to innate and adaptive immune responses are enriched.
“enriched genes related to innate and adaptive immune responses were identified in biopsy or explant tissues of patients with giant cell myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [188]
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Research works printed but not linked: 5
- [1]Bang V, Ganatra S, Shah SP,. Management of Patients With Giant Cell Myocarditis. Journal of the American College of Cardiology. 2021; 77: 1122– 1134. 33632487
- [2]Xu J and Brooks EG. Giant Cell Myocarditis: A Brief Review. Arch Pathol Lab Med. 2016; 140: 1429– 1434. 27922771
- [3]Salem JE, Allenbach Y, Vozy A, Brechot N, Johnson DB, Moslehi JJ, Kerneis M. Abatacept for Severe Immune Checkpoint Inhibitor-Associated Myocarditis. N Engl J Med. 2019; 380: 2377– 2379. 31189043
- [4]Kittleson MM, Minhas KM, Irizarry RA, Ye SQ, Edness G, Breton E, Conte JV, Tomaselli G, Garcia JG, Hare JM. Gene expression in giant cell myocarditis: Altered expression of immune response genes. Int J Cardiol. 2005; 102: 333– 40. 15982506
- [5]Lassner D, Kuhl U, Siegismund CS, Rohde M, Elezkurtaj S, Escher F, Tschope C, Gross UM, Poller W, Schultheiss HP. Improved diagnosis of idiopathic giant cell myocarditis and cardiac sarcoidosis by myocardial gene expression profiling. Eur Heart J. 2014; 35: 2186– 95. 24667923
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
Self-citation
- Authors
- Amancherla, K., Qin, J., Wang, Y., Axelrod, M. L., Balko, J. M., Schlendorf, K. H., Hoffman, R. D., Xu, Y., Lindenfeld, J., & Moslehi, J.
- Affiliations
- Vanderbilt University Medical Center (US)
- ORCID
- Venue
- Circulation Research
- Published
- 2021-07-23
- Volume
- 129
- Issue
- 3
- Pages
- 451-453
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC8380472
- OpenAlex
- W3171208086
- Cited by
- 12
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- HHS | NIH | National Heart, Lung, and Blood Institute (R01HL141466)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- giant cell myocarditis, gene expression signatures, druggable targets, myocarditis, cardiac fibroblasts, gene expression profiling
- MeSH terms
- Abatacept, Drug Development, Network Pharmacology, Adult, Clinical Trials as Topic, Female, Humans, Male, Middle Aged, Myocarditis, Myocardium, Oxidative Phosphorylation, Giant Cells, Apoptosis, Interleukin 1 Receptor Antagonist Protein, Transcriptome
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