The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Cardiac Troponin Elevation, Cardiovascular Morbidity, and Outcome After Subarachnoid Hemorrhage
Abstract
Background— Cardiac troponin I (cTI) release occurs frequently after subarachnoid hemorrhage (SAH) and has been associated with a neurogenic form of myocardial injury. The prognostic significance and clinical impact of these elevations remain poorly defined. Methods and Results— We studied 253 SAH patients who underwent serial cTI measurements for clinical or ECG signs of potential cardiac injury. These patients were drawn from an inception cohort of 441 subjects enrolled in the Columbia University SAH Outcomes Project between November 1998 and August 2002. Peak cTI levels were divided into quartiles or classified as undetectable. Adverse in-hospital events were prospectively recorded, and outcome at 3 months was assessed with the modified Rankin Scale. Admission predictors of cTI elevation included poor clinical grade, intraventricular hemorrhage, loss of consciousness at ictus, global cerebral edema, and a composite score of physiological derangement (all P ≤0.01). Peak cTI level was associated with an increased risk of echocardiographic left ventricular dysfunction (odds ratio [OR], 1.3 per quintile; 95% CI, 1.0 to 1.7; P =0.03), pulmonary edema (OR, 2.1 per quintile; 95% CI, 1.6 to 2.7; P <0.001), hypotension requiring pressors (OR, 1.9 per quintile; 95% CI, 1.5 to 2.3; P <0.001), and delayed cerebral ischemia from vasospasm (OR, 1.3 per quintile; 95% CI, 1.07 to 1.7; P =0.01). Peak cTI levels were predictive of death or severe disability at discharge after controlling for age, clinical grade, and aneurysm size (adjusted OR, 1.4 per quintile; 95% CI, 1.1 to 1.9; P =0.02), but this association was no longer significant at 3 months. Conclusions— cTI elevation after SAH is associated with an increased risk of cardiopulmonary complications, delayed cerebral ischemia, and death or poor functional outcome at discharge.
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Self-citationA Multinational Comparison of Subarachnoid Hemorrhage Epidemiology in the WHO MONICA Stroke Study
Ingall, T., Asplund, K., Mähönen, M., & Bonita, R. (2000) · Stroke · doi:10.1161/01.str.31.5.1054 · Cited by 515
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Myocardial Injury and Left Ventricular Performance After Subarachnoid Hemorrhage
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Self-citationCardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage
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Effect of acute physiologic derangements on outcome after subarachnoid hemorrhage*
Claassen, J., Vu, A., Kreiter, K. T., Kowalski, R. G., Du, E. Y., Ostapkovich, N., Fitzsimmons, B.-F. M., Connolly, E. S., & Mayer, S. A. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000114830.48833.8a · Cited by 221
Self-citationSerial electrocardiographic recording in aneurysmal subarachnoid hemorrhage.
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Cardiac injury associated with neurogenic pulmonary edema following subarachnoid hemorrhage
Mayer, S. A., Fink, M. E., Homma, S., Sherman, D., LiMandri, G., Lennihan, L., Solomon, R. A., Klebanoff, L. M., Beckford, A., & Raps, E. C. (1994) · Neurology · doi:10.1212/wnl.44.5.815 · Cited by 208
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Cited by
Dreier, J. P. (2011) · Nature Medicine · doi:10.1038/nm.2333 · Cited by 1,132
Aneurysmal Subarachnoid Hemorrhage
Suarez, J. I., Tarr, R. W., & Selman, W. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052732 · Cited by 986
Newby, L. K., Jesse, R. L., Babb, J. D., Christenson, R. H., De Fer, T. M., Diamond, G. A., Fesmire, F. M., Geraci, S. A., Gersh, B. J., Larsen, G. C., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.969 · Cited by 402
Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury
Sposato, L. A., Hilz, M. J., Aspberg, S., Murthy, S. B., Bahit, M. C., Hsieh, C.-Y., Sheppard, M. N., & Scheitz, J. F. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.009 · Cited by 313
Heart–Brain Axis: Effects of Neurologic Injury on Cardiovascular Function
Tahsili-Fahadan, P., & Geocadin, R. G. (2017) · Circulation Research · doi:10.1161/circresaha.116.308446 · Cited by 291
Metadata
- Authors
- Naidech, A. M., Kreiter, K. T., Janjua, N., Ostapkovich, N. D., Parra, A., Commichau, C., Fitzsimmons, B.-F. M., Connolly, E. S., & Mayer, S. A.
- Venue
- Circulation
- Published
- 2005-11
- Volume
- 112
- Issue
- 18
- Pages
- 2851-2856
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2169526588
- Cited by
- 344
- References
- 14
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Naidech, A. M., Kreiter, K. T., Janjua, N., Ostapkovich, N. D., Parra, A., Commichau, C., Fitzsimmons, B.-F. M., Connolly, E. S., & Mayer, S. A. (2005). Cardiac Troponin Elevation, Cardiovascular Morbidity, and Outcome After Subarachnoid Hemorrhage. Circulation. https://doi.org/10.1161/circulationaha.105.533620
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