The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Management of Massive Pulmonary Embolism
Open accessAbstract
Background—Acute massive pulmonary embolism (PE) carries an exceptionally high mortality rate. We explored how often adjunctive therapies, particularly thrombolysis and inferior vena caval (IVC) filter placement, were performed and how these therapies affected the clinical outcome of patients with massive PE. Methods and Results—Among 2392 patients with acute PE and known systolic arterial blood pressure at presentation, from the International Cooperative Pulmonary Embolism Registry (ICOPER), 108 (4.5%) had massive PE, defined as a systolic arterial pressure 90 mm Hg, and 2284 (95.5%) had non–massive PE with a systolic arterial pressure 90 mm Hg. PE was first diagnosed at autopsy in 16 patients (15%) with massive PE and in 29 patients (1%) with non–massive PE (P0.001). The 90-day mortality rates were 52.4 % (95 % CI, 43.3 % to 62.1%) and 14.7 % (95 % CI, 13.3 % to 16.2%), respectively. In-hospital bleeding complications occurred in 17.6 % versus 9.7 % and recurrent PE within 90 days in 12.6 % and 7.6%, respectively (P0.001). In patients with massive PE, thrombolysis, surgical embolectomy, or catheter embolectomy were withheld in 73 (68%). Thrombolysis was performed in 33 patients, surgical embolectomy in 3, and catheter embolectomy in 1. Thrombolytic therapy did not reduce 90-day mortality (thrombolysis, 46.3%; 95 % CI, 31.0 % to 64.8%; no thrombolysis, 55.1%; 95 % CI, 44.3 % to 66.7%; hazard ratio, 0.79; 95 % CI, 0.44 to 1.43). Recurrent PE rates at 90 days were similar in patients with and without thrombolytic therapy (12 % for both; P0.99). None of the 11 patients who received an IVC filter developed recurrent PE within 90 days, and 10 (90.9%)
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Self-citationAntithrombotic Therapy for Venous Thromboembolic Disease
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Right heart thrombi in pulmonary embolism
Torbicki, A., Galié, N., Covezzoli, A., Rossi, E., De Rosa, M., & Goldhaber, S. Z. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00479-0 · Cited by 518
Self-citationSchoepf, U. J., Kucher, N., Kipfmueller, F., Quiroz, R., Costello, P., & Goldhaber, S. Z. (2004) · Circulation · doi:10.1161/01.cir.0000147612.59751.4c · Cited by 489
Self-citationJerjes-Sanchez, C., Ramírez-Rivera, A., de Lourdes García, M., Arriaga-Nava, R., Valencia, S., Rosado-Buzzo, A., Pierzo, J. A., & Rosas, E. (1995) · Journal of Thrombosis and Thrombolysis · doi:10.1007/bf01062714 · Cited by 485
Cardiac Biomarkers for Risk Stratification of Patients With Acute Pulmonary Embolism
Kucher, N., & Goldhaber, S. Z. (2003) · Circulation · doi:10.1161/01.cir.0000100687.99687.ce · Cited by 325
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Cited by
Kucher, N., Rossi, E., De Rosa, M., & Goldhaber, S. Z. (2006) · Circulation · doi:10.1161/circulationaha.105.592592 · Cited by 780
Self-citationKuo, W. T., Gould, M. K., Louie, J. D., Rosenberg, J. K., Sze, D. Y., & Hofmann, L. V. (2009) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2009.08.002 · Cited by 504
Chronic thromboembolic pulmonary hypertension
Hoeper, M. M., Madani, M. M., Nakanishi, N., Meyer, B., Cebotari, S., & Rubin, L. J. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70089-x · Cited by 272
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Metadata
- Authors
- Kucher, N., & Goldhaber, S. Z.
- Venue
- Circulation
- Published
- 2005-07-12
- Volume
- 112
- Issue
- 2
- Pages
- e28-32
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2058411733
- Cited by
- 300
- References
- 23
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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