The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure
Open accessAbstract
Background— To support the clinical distinction between systolic heart failure (SHF) and diastolic heart failure (DHF), left ventricular (LV) myocardial structure and function were compared in LV endomyocardial biopsy samples of patients with systolic and diastolic heart failure. Methods and Results— Patients hospitalized for worsening heart failure were classified as having SHF (n=22; LV ejection fraction (EF) 34±2%) or DHF (n=22; LVEF 62±2%). No patient had coronary artery disease or biopsy evidence of infiltrative or inflammatory myocardial disease. More DHF patients had a history of arterial hypertension and were obese. Biopsy samples were analyzed with histomorphometry and electron microscopy. Single cardiomyocytes were isolated from the samples, stretched to a sarcomere length of 2.2 μm to measure passive force (F passive ), and activated with calcium-containing solutions to measure total force. Cardiomyocyte diameter was higher in DHF (20.3±0.6 versus 15.1±0.4 μm, P <0.001), but collagen volume fraction was equally elevated. Myofibrillar density was lower in SHF (36±2% versus 46±2%, P <0.001). Cardiomyocytes of DHF patients had higher F passive (7.1±0.6 versus 5.3±0.3 kN/m 2 ; P <0.01), but their total force was comparable. After administration of protein kinase A to the cardiomyocytes, the drop in F passive was larger ( P <0.01) in DHF than in SHF. Conclusions— LV myocardial structure and function differ in SHF and DHF because of distinct cardiomyocyte abnormalities. These findings support the clinical separation of heart failure patients into SHF and DHF phenotypes.
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Cites
Kitzman, D. W. (2002) · JAMA · doi:10.1001/jama.288.17.2144 · Cited by 883
Cardiomyocyte stiffness in diastolic heart failure
Borbély, A., van der Velden, J., Papp, Z., Bronzwaer, J. G. F., Edes, I., Stienen, G. J. M., & Paulus, W. J. (2005) · Circulation · doi:10.1161/01.cir.0000155257.33485.6d · Cited by 536
Nagueh, S. F., Shah, G., Wu, Y., Torre-Amione, G., King, N. M. P., Lahmers, S., Witt, C. C., Becker, K., Labeit, S., & Granzier, H. L. (2004) · Circulation · doi:10.1161/01.cir.0000135591.37759.af · Cited by 486
Cited by
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564
Self-citationPaulus, W. J., Tschöpe, C., Sanderson, J. E., Rusconi, C., Flachskampf, F. A., Rademakers, F. E., Marino, P., Smiseth, O. A., De Keulenaer, G., Leite-Moreira, A. F., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm037 · Cited by 2,679
Self-citationMohammed, S. F., Hussain, S., Mirzoyev, S. A., Edwards, W. D., Maleszewski, J. J., & Redfield, M. M. (2015) · Circulation · doi:10.1161/circulationaha.114.009625 · Cited by 874
The pathophysiology of heart failure with preserved ejection fraction
Borlaug, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.83 · Cited by 726
van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.728550 · Cited by 723
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Metadata
- Authors
- van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J., & Paulus, W. J.
- Venue
- Circulation
- Published
- 2006-04-25
- Volume
- 113
- Issue
- 16
- Pages
- 1966-1973
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2106909429
- Cited by
- 664
- References
- 3
- FWCI
- 28.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J., & Paulus, W. J. (2006). Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure. Circulation. https://doi.org/10.1161/circulationaha.105.587519
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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