The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Altered Creatine Kinase Adenosine Triphosphate Kinetics in Failing Hypertrophied Human Myocardium
Open accessAbstract
Background— The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. Methods and Results— We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (n=10) than in normal subjects (n=14, P <0.006). Left ventricular mass and CK metabolite levels in LVH were not different from those in patients with LVH and heart failure (LVH+CHF, n=10); however, the myocardial CK pseudo first-order rate constant was normal in LVH (0.36±0.04 s −1 in LVH versus 0.32±0.06 s −1 in normal subjects) but halved in LVH+CHF (0.17±0.06 s −1 , P <0.001). The net ATP flux through CK was significantly reduced by 30% in LVH (2.2±0.7 μmol · g −1 · s −1 , P =0.011) and by a dramatic 65% in LVH+CHF (1.1±0.4 μmol · g −1 · s −1 , P <0.001) compared with normal subjects (3.1±0.8 μmol · g −1 · s −1 ). Conclusions— These first observations in human LVH demonstrate that it is not the relative or absolute CK metabolite pool sizes but rather the kinetics of ATP turnover through CK that distinguish failing from nonfailing hypertrophic hearts. Moreover, the deficit in ATP kinetics is similar in systolic and nonsystolic heart failure and is not related to the severity of hypertrophy but to the presence of CHF. Because CK temporally buffers ATP, these observations support the hypothesis that a deficit in myofibrillar energy delivery contributes to CHF pathophysiology in human LVH.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The same quantitative 31P magnetic resonance spectroscopy protocols for measuring human myocardial metabolite concentrations and CK kinetics used here, previously revealed significant reductions in myocardial CK flux inpatients with non-ischemic dilated cardiomyopathy7, and left ventricular hypertrophy secondary to hypertension6.”
The cited source says what the claim attributes to it.
In the citing paper
“The present work extends the observation of reduced kf and CK flux in patients who have both heart failure and hypertrophy produced by pressure overload6, to those with hypertrophy of genetic origin–specifically those with an Arg403Gln point mutation in MH.”
The cited source says what the claim attributes to it.
In the citing paper
“Indeed, the magnitude of the reduction is comparable, albeit less than, the 50–65% reductions observed previously in other heart failure patients6,7.”
From iRhythm ZIO: The Diagnostic Yield of a 14-day Continuous Ambulatory ECG Monitor (Turakhia et al., diagnostic yield of extended ambulatory ECG monitoring) (2013) · cites this paper as [6]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“With inorganic phosphate [Pi] conservatively estimated at 1μmol/g wet wt6,7 in both control and HC patients, the free-energy release with ATP hydrolysis is similar in both groups (ΔG~ATP. −58.5±0.4 vs −58.3±1.3 kJ/mol).”
From iRhythm ZIO: The Diagnostic Yield of a 14-day Continuous Ambulatory ECG Monitor (Turakhia et al., diagnostic yield of extended ambulatory ECG monitoring) (2013) · cites this paper as [6]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
The natural history of congestive heart failure: the Framingham study
McKee, P. A., Castelli, W. P., McNamara, P. M., & Kannel, W. B. (1971) · New England Journal of Medicine · doi:10.1056/nejm197112232852601 · Cited by 3,448
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
Frey, N., & Olson, E. N. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142243 · Cited by 1,480
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction
Vasan, R. S., Larson, S., Benjamin, E. J., Evans, J. C., Reiss, C. K., & Levy, D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00118-7 · Cited by 1,331
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
Neely, J. R., & Morgan, H. E. (1974) · Annual Review of Physiology · doi:10.1146/annurev.ph.36.030174.002213 · Cited by 1,266
Measurement of Coronary Sinus Blood Flow by Continuous Thermodilution in Man
Ganz, W., Tamura, K., Marcus, H. S., DONOSO, R., Yoshida, S., & SWAN, H. J. C. (1971) · Circulation · doi:10.1161/01.cir.44.2.181 · Cited by 961
Heart failure with preserved left ventricular systolic function
Hogg, K. J., Swedberg, K. B., & McMurray, J. J. V. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.046 · Cited by 927
Mechanisms and Models in Heart Failure
Mann, D. L., & Bristow, M. R. (2005) · Circulation · doi:10.1161/circulationaha.104.500546 · Cited by 885
Phosphotransfer networks and cellular energetics
Dzeja, P. P., & Terzic, A. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00426 · Cited by 481
Cardiac hypertrophy: Useful adaptation or pathologic process?
Grossman, W. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90471-4 · Cited by 466
The creatine kinase system in normal and diseased human myocardium
Ingwall, J. S., Kramer, M. F., Fifer, M. A., Lorell, B. H., Shemin, R., Grossman, W., & Allen, P. D. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510243131704 · Cited by 396
Neubauer, S., Krahe, T., Schindler, R., Horn, M., Hillenbrand, H. B., Entzeroth, C., Mader, H., Kromer, E. P., Riegger, G. A. J., & Lackner, K. J. (1992) · Circulation · doi:10.1161/01.cir.86.6.1810 · Cited by 390
Beer, M., Seyfarth, T., Sandstede, J. J. W., Landschütz, W., Lipke, C. S. A., Köstler, H., von Kienlin, M., Harre, K., Hahn, D., & Neubauer, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02160-5 · Cited by 389
ATP flux through creatine kinase in the normal, stressed, and failing human heart
Weiss, R. G., Gerstenblith, G., & Bottomley, P. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408962102 · Cited by 350
Self-citationLiao, R., Jain, M., Cui, L., D’Agostino, J., Aiello, F., Luptak, I., Ngoy, S., Mortensen, R. M., & Tian, R. (2002) · Circulation · doi:10.1161/01.cir.0000034049.61181.f3 · Cited by 333
Conway, M. A., Allis, J. L., Ouwerkerk, R., Niioka, T., Rajagopalan, B., & Radda, G. K. (1991) · The Lancet · doi:10.1016/0140-6736(91)91838-l · Cited by 318
Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy
Hardy, C. J., Weiss, R. G., Bottomley, P. A., & Gerstenblith, G. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90527-o · Cited by 255
Self-citationEnergetic Crosstalk Between Organelles
Kaasik, A., Veksler, V., Boehm, E. A., Novotová, M., Minajeva, A., & Ventura‐Clapier, R. (2001) · Circulation Research · doi:10.1161/hh1401.093440 · Cited by 252
Diastolic Dysfunction in Hypertensive Heart Disease Is Associated With Altered Myocardial Metabolism
Lamb, H. J., Beyerbacht, H. P., van der Laarse, A., Stoel, B. C., Doornbos, J., van der Wall, E. E., & Roos, A. (1999) · Circulation · doi:10.1161/01.cir.99.17.2261 · Cited by 239
Jung, W.-I., Sieverding, L., Breuer, J., Hoess, T., Widmaier, S., Schmidt, O., Bunse, M., van Erckelens, F., Apitz, J., Lutz, O., et al. (1998) · Circulation · doi:10.1161/01.cir.97.25.2536 · Cited by 197
Yabe, T., Mitsunami, K., Inubushi, T., & Kinoshita, M. (1995) · Circulation · doi:10.1161/01.cir.92.1.15 · Cited by 177
MR spectroscopy of the human heart: the status and the challenges.
Bottomley, P. A. (1994) · Radiology · doi:10.1148/radiology.191.3.8184033 · Cited by 163
Self-citationNakae, I., Mitsunami, K., Omura, T., Yabe, T., Tsutamoto, T., Matsuo, S., Takahashi, M., Morikawa, S., Inubushi, T., Nakamura, Y., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.05.005 · Cited by 146
Bittl, J. A., Delayre, J. L., & Ingwall, J. S. (1987) · Biochemistry · doi:10.1021/bi00393a021 · Cited by 140
Bottomley, P. A., Hardy, C. J., & Roemer, P. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140302 · Cited by 136
Self-citationBioenergetics: Dissecting the role of creatine kinase
Wallimann, T. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00008-7 · Cited by 133
High-Energy Phosphate Metabolism and Creatine Kinase in Failing Hearts
Ye, Y., Gong, G., 落合, 康., Liu, J., & Zhang, J. J. (2001) · Circulation · doi:10.1161/01.cir.103.11.1570 · Cited by 125
Simultaneous measurement of myocardial oxygen consumption and blood flow using [1-carbon-11]acetate.
Sun, K., Yeatman, L. A., Buxton, D. B., Chen, K., Johnson, J. A., Huang, S., Kofoed, K. F., Weismüller, S., Czernin, J. G., Phelps, M. E., et al. (1998) · PubMed · Cited by 123
Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy.
Bottomley, P. A., Herfkens, R. J., Smith, L. S., & Bashore, T. M. (1987) · Radiology · doi:10.1148/radiology.165.3.2961004 · Cited by 117
Self-citationLaine, H. K., Katoh, C., Luotolahti, M., Yki‐Järvinen, H., Kantola, I. M., Jula, A., Takala, T., Ruotsalainen, U., Iida, H., Haaparanta‐Solin, M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.24.2425 · Cited by 106
Human cardiac high‐energy phosphate metabolite concentrations by 1D‐resolved NMR spectroscopy
Bottomley, P. A., Atalar, E., & Weiss, R. G. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350507 · Cited by 96
Self-citationFour‐angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo
Bottomley, P. A., Ouwerkerk, R., Lee, R. F., & Weiss, R. G. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10130 · Cited by 95
Self-citationOxidative capacity in failing hearts
Gong, G., Liu, J., Liang, P., Guo, T., Hu, Q., Ochiai, K., Hou, M., Ye, Y., Wu, X., Mansoor, A., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01142.2002 · Cited by 95
Saupe, K. W., Spindler, M., Hopkins, J. C. A., Shen, W., & Ingwall, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001932200 · Cited by 93
Myocardial Oxygen Consumption During Ventricular Contraction and Relaxation
MONROE, R. G. (1964) · Circulation Research · doi:10.1161/01.res.14.4.294 · Cited by 93
Massie, B. M., Schaefer, S., Garcia, J., McKirnan, M. D., Schwartz, G. G., Wisneski, J. A., Weiner, M. W., & White, F. C. (1995) · Circulation · doi:10.1161/01.cir.91.6.1814 · Cited by 91
Bittl, J. A., Balschi, J. A., & Ingwall, J. S. (1987) · Circulation Research · doi:10.1161/01.res.60.6.871 · Cited by 89
Smith, S. H., Kramer, M. F., Reis, I., Bishop, S. P., & Ingwall, J. S. (1990) · Circulation Research · doi:10.1161/01.res.67.6.1334 · Cited by 85
Robitaille, P.-M. L., Merkle, H., Lew, B. T., Path, G., Hendrich, K. S., Lindstrom, P., From, A. H. L., Garwood, M., Bache, R. J., & Uǧurbil, K. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910160110 · Cited by 85
Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy
Bache, R. J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00332-0 · Cited by 79
Spindler, M., Meyer, K., Strömer, H., Leupold, A., Boehm, E. A., Wagner, H., & Neubauer, S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01016.2003 · Cited by 78
Bioenergetic consequences of cardiac phosphocreatine depletion induced by creatine analogue feeding.
Zweier, J. L., Jacobus, W. E., KORECKY, B., & Brandejs-Barry, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54922-x · Cited by 76
Okada, M., Mitsunami, K., Inubushi, T., & Kinoshita, M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390515 · Cited by 60
Horn, M., Remkes, H., Strömer, H., Dienesch, C., & Neubauer, S. (2001) · Circulation · doi:10.1161/hc3901.095933 · Cited by 57
Crozatier, B., Badoual, T., Boehm, E. A., Ennezat, P., Guenoun, T., Su, J. B., Veksler, V., Hittinger, L., & Ventura‐Clapier, R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0652com · Cited by 54
Intracellular high-energy phosphate transfer in normal and hypertrophied myocardium.
Bittl, J. A., & Js, I. (1987) · PubMed · Cited by 45
Myocardial creatine kinase kinetics and isoform expression in hearts with severe LV hypertrophy
Ye, Y., Wang, C., Zhang, J. J., Cho, Y. K., Gong, G., Murakami, Y., & Bache, R. J. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.1.h376 · Cited by 40
Gated in vivo examination of cardiac metabolites with 31P nuclear magnetic resonance
Kantor, H. L., Briggs, R. W., Metz, K. R., & Balaban, R. S. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.251.1.h171 · Cited by 35
Creatine Phosphate Consumption and the Actomyosin Crossbridge Cycle in Cardiac Muscles
Ogut, O., & Brozovich, F. V. (2003) · Circulation Research · doi:10.1161/01.res.0000080536.06932.e3 · Cited by 16
Shulman, R. G., & Rothman, D. L. (2005) · Cited by 14
(2004) · Wiley eBooks · doi:10.1002/0470011505 · Cited by 11
The energy cost of relaxation in control and hypertrophic rabbit papillary muscles
Gibbs, C. L., Wendt, I. R., Kotsanas, G., & Young, I. R. (1990) · Heart and Vessels · doi:10.1007/bf02058690 · Cited by 7
Shulman, R. G., & Rothman, D. L. (2004) · doi:10.1002/0470011505.ch9 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 13
- 10.1161/circ.91.6.1814 · DOI
- 10.1161/circ.103.11.1570 · DOI
- 10.1161/circ.99.17.2261 · DOI
- 10.1161/circ.86.6.1451253 · DOI
- 10.1161/res.60.6.2954720 · DOI
- 10.1161/res.67.6.2147129 · DOI
- 10.1161/circ.92.1.15 · DOI
- 10.1161/circ.100.24.2425 · DOI
- 10.1161/circ.97.25.2536 · DOI
- 10.1161/circ.104.15.1844 · DOI
- 10.1161/res.89.2.153 · DOI
- 10.1161/circ.44.2.181 · DOI
- 10.1161/res.14.4.294 · DOI
Cited by
Sorted by citations
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
Borlaug, B. A., & Paulus, W. J. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq426 · Cited by 1,136
Mitochondrial dysfunction in pathophysiology of heart failure
Zhou, B., & Tian, R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120849 · Cited by 973
Mitochondrial function as a therapeutic target in heart failure
Brown, D. A., Perry, J. B., Allen, M. E., Sabbah, H. N., Stauffer, B. L., Shaikh, S. R., Cleland, J. G. F., Colucci, W. S., Butler, J., Voors, A. A., et al. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.203 · Cited by 829
Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Olson, T. P., Lam, C. S. P., Flood, K. S., Lerman, A., Johnson, B. D., & Redfield, M. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.077 · Cited by 733
Metabolic Mechanisms in Heart Failure
Ashrafian, H., Frenneaux, M. P., & Opie, L. H. (2007) · Circulation · doi:10.1161/circulationaha.107.702795 · Cited by 522
Metadata
- Authors
- Smith, C. S., Bottomley, P. A., Schulman, S. P., Gerstenblith, G., & Weiss, R. G.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Circulation
- Published
- 2006-09-12
- Volume
- 114
- Issue
- 11
- Pages
- 1151-1158
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC1808438
- OpenAlex
- W2111571221
- Cited by
- 204
- References
- 53
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 13 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 13 · 2012: 9
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Donald W. Reynolds Foundation
- National Heart, Lung, and Blood Institute (HL61912, HL-63030, R01HL063030, R01HL061912, R01HL056882, HL56882)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- creatine kinase, adenosine triphosphate, left ventricular hypertrophy, chronic heart failure, myocardial energy metabolism, phosphocreatine, ATP turnover, pressure overload, heart failure pathophysiology
- MeSH terms
- Adenosine Triphosphate, Adult, Aged, Cardiac Output, Low, Creatine Kinase, Energy Metabolism, Female, Heart, Heart Ventricles, Humans, Male, Middle Aged, Myocardium, Severity of Illness Index, Hypertrophy, Left Ventricular, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
