Metoprolol Reverses Left Ventricular Remodeling in Patients With Asymptomatic Systolic Dysfunction: The REversal of VEntricular Remodeling with Toprol-XL (REVERT) Trial
Abstract
Background There are no randomized, controlled trial data to support the benefit of beta-blockers in patients with asymptomatic left ventricular systolic dysfunction. We investigated whether beta-blocker therapy ameliorates left ventricular remodeling in asymptomatic patients with left ventricular systolic dysfunction. Method and results Patients with left ventricular ejection fraction Conclusion Beta-blocker therapy can ameliorate left ventricular remodeling in asymptomatic patients with left ventricular systolic dysfunction.
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In the REVERT trial, metoprolol improved adverse cardiac remodeling in asymptomatic individuals with an LVEF <40% and mild left ventricular dilatation.
“in the Reversal of Ventricular Remodeling With Toprol-XL (REVERT) trial, in which 45% of the people enrolled had diabetes, metoprolol improved adverse cardiac remodeling in asymptomatic individuals with an LVEF <40% and mild left ventricular dilatation (283).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [283]
In the REVERT trial, metoprolol improved adverse cardiac remodeling in asymptomatic individuals with an LVEF <40% and mild left ventricular dilatation.
“Finally, in the Reversal of Ventricular Remodeling With Toprol-XL (REVERT) trial, in which 45% of the people enrolled had diabetes, metoprolol improved adverse cardiac remodeling in asymptomatic individuals with an LVEF <40% and mild left ventricular dilatation (280).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [280]
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References 29 · Cited by 181
- Authors
- Colucci, W. S., Kolias, T. J., Adams, K. F., Armstrong, W. F., Ghali, J. K., Gottlieb, S. S., Greenberg, B., Klibaner, M. I., Kukin, M. L., & Sugg, J. E.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Circulation
- Published
- 2007-07-03
- Volume
- 116
- Issue
- 1
- Pages
- 49-56
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2065866662
- Cited by
- 181
- References
- 29
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 14
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- metoprolol, beta-blockers, left ventricular remodeling, heart failure with preserved ejection fraction, left ventricular ejection fraction, end-systolic volume, end-diastolic volume, left ventricular mass, brain natriuretic peptide
- MeSH terms
- Adrenergic beta-Antagonists, Aged, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Cardiovascular Agents, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Heart Rate, Humans, Male, Metoprolol, Middle Aged, Stroke Volume, Ultrasonography, Treatment Outcome, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain, Ventricular Remodeling, Angiotensin II Type 1 Receptor Blockers
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