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Cited by 117Heart Failure Treatment and ManagementThyroid Disorders and TreatmentsHormonal and reproductive studies

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

DITPA (3,5-Diiodothyropropionic Acid), a Thyroid Hormone Analog to Treat Heart Failure: Phase II Trial Veterans Affairs Cooperative Study

Goldman, Steven, McCarren, Madeline, Morkin, Eugene, Ladenson, Paul W., Edson, Robert, Warren, Stuart, Ohm, Janet, Thai, Hoang, Churby, Lori, Barnhill, Jamie, O'Brien, Terrence, Anand, Inder, Warner, Alberta, Hattler, Brack, Dunlap, Mark, Erikson, John, Shih, Mei-Chiung, Lavori, Phil·2009·Circulation
DOI 10.1161/circulationaha.108.834424
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Abstract

Background—In animal studies and a pilot trial in patients with congestive heart failure, the thyroid hormone analog 3,5 diiodothyropropionic acid (DITPA) had beneficial hemodynamic effects. Methods and Results—This was a phase II multicenter, randomized, placebo-controlled, double-blind trial of New York Heart Association class II to IV congestive heart failure patients randomized (2:1) to DITPA or placebo and treated for 6 months. The study enrolled 86 patients (n=57 to DITPA, n=29 to placebo). The primary objective was to assess the effect of DITPA on a composite congestive heart failure end point that classifies patients as improved, worsened, or unchanged based on symptom changes and morbidity/mortality. DITPA was poorly tolerated, which obscured the interpretation of congestive heart failure-specific effects. Fatigue and gastrointestinal complaints, in particular, were more frequent in the DITPA group. DITPA increased cardiac index (by 18%) and decreased systemic vascular resistance (by 11%), serum cholesterol (−20%), low-density lipoprotein cholesterol (−30%), and body weight (−11 lb). Thyroid-stimulating hormone was suppressed in patients given DITPA, which reflects its thyromimetic effect; however, no symptoms or signs of potential hypothyroidism or thyrotoxicosis were seen. Conclusions—DITPA improved some hemodynamic and metabolic parameters, but there was no evidence for symptomatic benefit in congestive heart failure.

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Crossref · 10.1161/circulationaha.108.834424

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Research works printed but not linked: 5

  1. 10.1161/circ.102.10.1076 · DOI
  2. 10.1161/circ.88.3.8353891 · DOI
  3. 10.1161/circ.91.3.794 · DOI
  4. 10.1097/00001648-199801000-00004 · DOI
  5. Pennock GD, Raya TE, Bahl JJ, Goldman S, Morkin E. Cardiac effects of 3,5-diiodothyroproprionic acid, a thyroid analog with inotropic selectivity. J Pharmacol Exp Ther. 1992; 263: 163–169. · DOI

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Metadata

Authors
Goldman, S., McCarren, M., Morkin, E., Ladenson, P. W., Edson, R., Warren, S., Ohm, J., Thai, H., Churby, L., Barnhill, J., O'Brien, T., Anand, I., Warner, A., Hattler, B., Dunlap, M., Erikson, J., Shih, M.-C., & Lavori, P.
Affiliations
  • University of Arizona (US)
  • From Cardiology, Southern Arizona VA Health Care System (S.G., J.O., H.T.), Tucson, Ariz; VA Pharmacy Benefits Management (M.M.), Hines, Ill; University of Arizona (E.M.), Tucson, Ariz; Johns Hopkins University (P.W.L.), Baltimore, Md; R&D Service (R.E., L.C., M.-C.S., P.L.), Veterans Affairs Medical Center, Palo Alto, Calif; R&D Service (S.W., J.B.), Veterans Affairs Medical Center, Albuquerque, NM; Cardiology (T.O.), Veterans Affairs Medical Center, Charleston, SC; Cardiology (I.A.),...
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-06-23
Volume
119
Issue
24
Pages
3093-3100
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.108.834424
OpenAlex
W2146450311
Cited by
117
References
28
Citations by year
2026: 2 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 8 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 7
FWCI
6.69
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
thyroid hormone analogs, congestive heart failure, cardiac index, systemic vascular resistance, serum cholesterol, TSH suppression, drug tolerability, fatigue, hypothyroidism
MeSH terms
Adolescent, Adult, Aged, Body Weight, Cholesterol, Diiodothyronines, Double-Blind Method, Fatigue, Female, Gastrointestinal Diseases, Heart Failure, Humans, Lipoproteins, LDL, Male, Middle Aged, Propionates, Thyroid Hormones, United States, United States Department of Veterans Affairs, Vascular Resistance

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