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Cited by 379Atrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Excessive Supraventricular Ectopic Activity and Increased Risk of Atrial Fibrillation and Stroke

Binici, Zeynep, Intzilakis, Theodoros, Nielsen, Olav Wendelboe, Køber, Lars, Sajadieh, Ahmad·2010·Circulation
DOI 10.1161/circulationaha.109.874982
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Abstract

BACKGROUND: Prediction of stroke and atrial fibrillation in healthy individuals is challenging. We examined whether excessive supraventricular ectopic activity (ESVEA) correlates with risk of stroke, death, and atrial fibrillation in subjects without previous stroke or heart disease. METHODS AND RESULTS: The population-based cohort of the Copenhagen Holter Study, consisting of 678 healthy men and women aged between 55 and 75 years with no history of cardiovascular disease, atrial fibrillation, or stroke, was evaluated. All had fasting laboratory tests and 48-hour ambulatory ECG monitoring. ESVEA was defined as >or=30 supraventricular ectopic complexes (SVEC) per hour or as any episodes with runs of >or=20 SVEC. The primary end point was stroke or death, and the secondary end points were total mortality, stroke, and admissions for atrial fibrillation. Median follow-up was 6.3 years. Seventy subjects had SVEC>or=30/h, and 42 had runs of SVEC with a length of >or=20 SVEC. Together, 99 subjects (14.6%) had ESVEA. The risk of primary end point (death or stroke) was significantly higher in subjects with ESVEA compared with those without ESVEA after adjustment for conventional risk factors (hazard ratio=1.64; 95% confidence interval, 1.03 to 2.60; P=0.036). ESVEA was also associated with admissions for atrial fibrillation (hazard ratio=2.78; 95% confidence interval, 1.08 to 6.99; P=0.033) and stroke (hazard ratio=2.79; 95% confidence interval, 1.23 to 6.30; P=0.014). SVEC, as a continuous variable, was also associated with both the primary end point of stroke or death and admissions for atrial fibrillation. CONCLUSIONS: ESVEA in apparently healthy subjects is associated with development of atrial fibrillation and is associated with a poor prognosis in term of death or stroke.

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Crossref · 10.1161/circulationaha.109.874982

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  1. 10.1161/str.19.11.3188119 · DOI
  2. 10.1161/str.31.12.2925 · DOI

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Metadata

Authors
Binici, Z., Intzilakis, T., Nielsen, O. W., Køber, L., & Sajadieh, A.
Affiliations
Amager Hospital (DK)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-05-04
Volume
121
Issue
17
Pages
1904-1911
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.109.874982
OpenAlex
W2011158253
Cited by
379
References
26
Citations by year
2026: 12 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 34 · 2021: 27 · 2020: 28 · 2019: 23 · 2018: 25 · 2017: 33 · 2016: 32 · 2015: 34 · 2014: 20 · 2013: 18 · 2012: 14
FWCI
10.56
Type
journal article
Language
en
Update notices
correction (2010-09-28)
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
Hjerteforeningen
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
atrial fibrillation, stroke, mortality, cardiac arrhythmias, Holter monitoring, cardiovascular risk prediction, healthy adults
MeSH terms
Aged, Atrial Fibrillation, Denmark, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Prognosis, Risk Factors, Urban Population, Electrocardiography, Ambulatory, Incidence, Prevalence, Proportional Hazards Models, Atrial Premature Complexes, Stroke, Kaplan-Meier Estimate

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