The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Randomized Comparison of Strategies for Type B Aortic Dissection: The INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) Trial
Abstract
Background— Thoracic endovascular aortic repair (TEVAR) represents a novel concept for type B aortic dissection. Although life-saving in acute emergencies, outcomes and survival of TEVAR in stable dissection are unknown. Methods and Results— One hundred forty patients in stable clinical condition at least 2 weeks after index dissection were randomly subjected to elective stent-graft placement in addition to optimal medical therapy (n=72) or to optimal medical therapy alone (n=68) with surveillance (arterial pressure according to World Health Organization guidelines ≤120/80 mm Hg). The primary end point was all-cause death at 2 years, whereas aorta-related death, progression (with need for conversion or additional endovascular or open surgery), and aortic remodeling were secondary end points. There was no difference in all-cause deaths, with a 2-year cumulative survival rate of 95.6±2.5% with optimal medical therapy versus 88.9±3.7% with TEVAR ( P =0.15); the trial, however, turned out to be underpowered. Moreover, the aorta-related death rate was not different ( P =0.44), and the risk for the combined end point of aorta-related death (rupture) and progression (including conversion or additional endovascular or open surgery) was similar ( P =0.65). Three neurological adverse events occurred in the TEVAR group (1 paraplegia, 1 stroke, and 1 transient paraparesis), versus 1 case of paraparesis with medical treatment. Finally, aortic remodeling (with true-lumen recovery and thoracic false-lumen thrombosis) occurred in 91.3% of patients with TEVAR versus 19.4% of those who received medical treatment ( P <0.001), which suggests ongoing aortic remodeling. Conclusions— In the first randomized study on elective stent-graft placement in survivors of uncomplicated type B aortic dissection, TEVAR failed to improve 2-year survival and adverse event rates despite favorable aortic remodeling. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00525356.
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Cites
The International Registry of Acute Aortic Dissection (IRAD): New Insights Into an Old Disease
Hagan, P. G., Nienaber, C. A., Isselbacher, E. M., Bruckman, D., Karavite, D. J., Russman, P. L., Evangelista, A., Fattori, R., Suzuki, T., Oh, J. K., et al. (2000) · JAMA · doi:10.1001/jama.283.7.897 · Cited by 3,623
Self-citationReporting standards for endovascular aortic aneurysm repair
Chaikof, E. L., Blankensteijn, J. D., Harris, P. L., White, G. H., Zarins, C. K., Bernhard, V. M., Matsumura, J. S., May, J., Veith, F. J., Fillinger, M. F., et al. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.123763 · Cited by 1,773
Erbel, R. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2782 · Cited by 1,217
Svensson, L. G., Kouchoukos, N. T., Miller, D. C., Bavaria, J. E., Coselli, J. S., Curi, M. A., Eggebrecht, H., Elefteriades, J. A., Erbel, R., Gleason, T. G., et al. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.10.099 · Cited by 860
Self-citationButh, J., Harris, P. L., Hobo, R., van Eps, R., Cuypers, P., Duijm, L., & Tielbeek, X. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.08.020 · Cited by 622
Suzuki, T., Mehta, R. H., Ince, H., Nagai, R., Sakomura, Y., Weber, F., Sumiyoshi, T., Bossone, E., Trimarchi, S., Cooper, J. V., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087386.07204.09 · Cited by 590
Self-citationEndovascular stent–graft placement in aortic dissection: a meta-analysis
Eggebrecht, H., Nienaber, C. A., Neuhäuser, M., Baumgart, D., Kische, S., Schmermund, A., Herold, U., Rehders, T. C., Jakob, H. G., & Erbel, R. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi493 · Cited by 535
Self-citationComplicated Acute Type B Dissection: Is Surgery Still the Best Option?
Fattori, R., Tsai, T. T., Myrmel, T., Evangelista, A., Cooper, J. V., Trimarchi, S., Li, J., Lovato, L., Kische, S., Eagle, K. A., et al. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2008.04.009 · Cited by 430
Self-citationErbel, R., Oelert, H., Meyer, J., Puth, M., Mohr-Katoly, S., Hausmann, D., Daniel, W., Maffei, S., Caruso, A., & Covino, F. E. (1993) · Circulation · doi:10.1161/01.cir.87.5.1604 · Cited by 408
Long-Term Predictors of Descending Aorta Aneurysmal Change in Patients With Aortic Dissection
Song, J.-M., Kim, S.-D., Kim, J.-H., Kim, M.-J., Kang, D.-H., Seo, J. B., Lim, T.-H., Lee, J. W., Song, M.-G., & Song, J.-K. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.064 · Cited by 342
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Erbel (2014) · doi:10.1093/eurheartj/ehu281 · Cited by 4,451
Interdisciplinary Expert Consensus Document on Management of Type B Aortic Dissection
Fattori, R., Cao, P., De Rango, P., Czerny, M., Evangelista, A., Nienaber, C., Rousseau, H., & Schepens, M. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.072 · Cited by 494
Self-citationSurvival After Endovascular Therapy in Patients With Type B Aortic Dissection
Fattori, R., Montgomery, D., Lovato, L., Kische, S., Di Eusanio, M., Ince, H., Eagle, K. A., Isselbacher, E. M., & Nienaber, C. A. (2013) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2013.05.003 · Cited by 434
Self-citationEACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ
Czerny, M., Grabenwöger, M., Berger, T., Aboyans, V., Della Corte, A., Chen, E. P., Desai, N. D., Dumfarth, J., Elefteriades, J. A., Etz, C. D., et al. (2024) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezad426 · Cited by 412
Self-citation(2014) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2014.05.007 · Cited by 259
Metadata
- Authors
- Nienaber, C. A., Rousseau, H., Eggebrecht, H., Kische, S., Fattori, R., Rehders, T. C., Kundt, G., Scheinert, D., Czerny, M., Kleinfeldt, T., Zipfel, B., Labrousse, L., & Ince, H.
- Venue
- Circulation
- Published
- 2009-12-22
- Volume
- 120
- Issue
- 25
- Pages
- 2519-2528
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2126242677
- Cited by
- 803
- References
- 16
- FWCI
- 39.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nienaber, C. A., Rousseau, H., Eggebrecht, H., Kische, S., Fattori, R., Rehders, T. C., Kundt, G., Scheinert, D., Czerny, M., Kleinfeldt, T., Zipfel, B., Labrousse, L., & Ince, H. (2009). Randomized Comparison of Strategies for Type B Aortic Dissection: The INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) Trial. Circulation. https://doi.org/10.1161/circulationaha.109.886408
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
