The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Secondary Prevention and Mortality in Peripheral Artery Disease: National Health and Nutrition Examination Study, 1999 to 2004
Open accessAbstract
Background—: Whether individuals with peripheral artery disease (PAD) identified by screening ankle-brachial index benefit from preventive therapies to reduce cardiovascular risk is unknown. We aimed to determine the number of US adults with PAD who are not receiving preventive therapies and whether treatment is associated with reduced mortality in PAD subjects without known cardiovascular disease. Methods and Results—: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004 with mortality follow-up through December 31, 2006. We defined PAD as an ankle-brachial index ≤0.90. Of 7458 eligible participants ≥40 years, weighted PAD prevalence was 5.9±0.3% (mean±SE), corresponding to ≈7.1 million US adults with PAD. Statin use was reported in only 30.5±2.5%, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use in 24.9±1.9%, and aspirin use in 35.8±2.9%, corresponding to 5.0 million adults with PAD not taking statins, 5.4 million not taking angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and 4.5 million not receiving aspirin. After adjustment for age, sex, and race/ethnicity, PAD was associated with all-cause mortality (hazard ratio, 2.4; 95% confidence interval, 1.9 to 2.9; P <0.0001). Even after exclusion of individuals with known cardiovascular disease, subjects with PAD had higher mortality rates (16.1±2.1%) than subjects without PAD or cardiovascular disease (4.1±0.3%), with an adjusted hazard ratio of 1.9 (95% confidence interval, 1.3 to 2.8; P =0.001). Among PAD subjects without cardiovascular disease, use of multiple preventive therapies was associated with 65% lower all-cause mortality (hazard ratio, 0.35; 95% confidence interval, 0.20 to 0.86; P =0.02). Conclusions—: Millions of US adults with PAD are not receiving secondary prevention therapies. Treatment with multiple therapies is associated with reduced all-cause mortality.
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Sex Differences in Peripheral Artery Disease
Aitken, S., & Kavurma, M. M. (2026) · Physiology in health and disease · doi:10.1007/978-3-032-26472-5_24
Park, J. (2026) · Family Medicine and Community Health · doi:10.1136/fmch-2026-004259
Statins Use in Veterans With Peripheral Artery Disease: Insights From the PEARLS Study
Nathani, R., Nguyen, C., Li, Q., Vaughan‐Sarrazin, M., Al-Garadi, M. A., Minniefield‐Young, N., Smolderen, K. G. E., Tsai, S. X., Arya, S., Beckman, J. A., et al. (2026) · Circulation Population Health and Outcomes · doi:10.1161/circoutcomes.125.013213
Self-citationWang, M., & Wang, Y. (2026) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2026.10.028
Krankheiten des Kreislaufsystems
Weber, F., & Bönner, G. (2012) · Springer eBooks · doi:10.1007/978-3-642-21081-5_12
General Considerations in the Diabetic Patient with Peripheral Vascular Disease
Kundi, R., Meltzer, A. J., & Bajakian, D. R. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-158-5_1
Metadata
- Authors
- Pande, R. L., Perlstein, T. S., Beckman, J. A., & Creager, M. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Circulation
- Published
- 2011-07-05
- Volume
- 124
- Issue
- 1
- Pages
- 17-23
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3139992
- OpenAlex
- W2082336558
- Semantic Scholar
- 91f0b40eb962eac5bce27896ae06727a10351d5f
- Cited by
- 406
- References
- 30
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 28 · 2023: 31 · 2022: 24 · 2021: 39 · 2020: 33 · 2019: 26 · 2018: 35 · 2017: 26 · 2016: 38 · 2015: 25 · 2014: 21 · 2013: 19 · 2012: 35
- FWCI
- 24.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K12HL083786, R01HL075771)
- Topics
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vascular Procedures and Complications
- Keywords
- peripheral arterial disease, secondary prevention, all-cause mortality, ankle-brachial index, statin use, ACE inhibitors, angiotensin receptor blockers, aspirin, cardiovascular risk reduction, untreated patients
- MeSH terms
- Aged, Angiotensin-Converting Enzyme Inhibitors, Aspirin, Cardiovascular Diseases, Female, Humans, Male, Nutrition Surveys, Retrospective Studies, Risk Factors, United States, Prevalence, Secondary Prevention, Angiotensin II Type 2 Receptor Blockers, Peripheral Arterial Disease
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