Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease: An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region
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Background—: Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations. Methods and Results—: Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and <1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9–33.3) of Asians versus 27.0% (95% CI, 26.5–27.5) of non-Asians ( P <0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2–22.5) versus 14.5% (95% CI, 14.1–14.9), respectively ( P <0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31–1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27–2.19] versus 1.63 [95% CI, 1.24–2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67–1.00] with isolated low HDL-C). Conclusion—: Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted.
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- Authors
- Huxley, R. R., Barzi, F., Lam, T. H., Czernichow, S., Fang, X., Welborn, T., Shaw, J., Ueshima, H., Zimmet, P., Jee, S. H., Patel, J. V., Caterson, I., Perkovic, V., Woodward, M., & for the Asia Pacific Cohort Studies Collaboration and the Obesity in Asia Collaboration
- Affiliations
- The University of Sydney (AU)
- From the George Institute (R.R.H., F.B., S.C., V.P., M.W.) and Boden Institute, Sydney Medical School (I.C.), University of Sydney, Sydney, Australia; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (R.R.H.); University of Hong Kong, School of Public Health/Department of Community Medicine, Hong Kong (T.H.L.); Department of Nutrition, Ambroise Paré Hospital and University of Versailles Saint Quentin en Yvelines, Boulogne-Billancourt, France (S.C.); Department of...
- ORCID
- Venue
- Circulation
- Published
- 2011-11-08
- Volume
- 124
- Issue
- 19
- Pages
- 2056-2064
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1967178573
- Cited by
- 144
- References
- 35
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 2 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 13 · 2013: 14 · 2012: 12
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (571281)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- coronary artery disease, stroke, dyslipidemia, Asian populations, lipid phenotypes, cardiovascular risk, prevalence, individual patient data meta-analysis, Asia-Pacific region, lipid metabolism disorders, cardiovascular hospitalization, cardiovascular risk factors
- MeSH terms
- Adult, Aged, Coronary Disease, Asia, Eastern, Female, Humans, India, Cholesterol, HDL, Male, Middle Aged, Obesity, Risk Factors, Prevalence, Australasia, Asian People, Dyslipidemias
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