The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography: Main Results From the Randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT)
Open accessAbstract
Background—: It remains uncertain whether acetylcysteine prevents contrast-induced acute kidney injury. Methods and Results—: We randomly assigned 2308 patients undergoing an intravascular angiographic procedure with at least 1 risk factor for contrast-induced acute kidney injury (age >70 years, renal failure, diabetes mellitus, heart failure, or hypotension) to acetylcysteine 1200 mg or placebo. The study drugs were administered orally twice daily for 2 doses before and 2 doses after the procedure. The allocation was concealed (central Web-based randomization). All analysis followed the intention-to-treat principle. The incidence of contrast-induced acute kidney injury (primary end point) was 12.7% in the acetylcysteine group and 12.7% in the control group (relative risk, 1.00; 95% confidence interval, 0.81 to 1.25; P =0.97). A combined end point of mortality or need for dialysis at 30 days was also similar in both groups (2.2% and 2.3%, respectively; hazard ratio, 0.97; 95% confidence interval, 0.56 to 1.69; P =0.92). Consistent effects were observed in all subgroups analyzed, including those with renal impairment. Conclusions—: In this large randomized trial, we found that acetylcysteine does not reduce the risk of contrast-induced acute kidney injury or other clinically relevant outcomes in at-risk patients undergoing coronary and peripheral vascular angiography. Clinical Trial Registration—: http://www.clinicaltrials.gov . Unique identifier: NCT00736866.
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Metadata
- Authors
- ACT Investigators*
- Venue
- Circulation
- Published
- 2011-09-13
- Volume
- 124
- Issue
- 11
- Pages
- 1250-1259
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1790120012
- Cited by
- 354
- References
- 40
- FWCI
- 30.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- ACT Investigators*. (2011). Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography: Main Results From the Randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT). Circulation. https://doi.org/10.1161/circulationaha.111.038943
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