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Cited by 226Acute Myocardial Infarction ResearchCoronary Interventions and DiagnosticsHeart rate and cardiovascular health

Unstable Angina: Is It Time for a Requiem?

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Braunwald, Eugene, Morrow, David A.·2013·Circulation
DOI 10.1161/circulationaha.113.001258
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  • The advent of increasingly sensitive cardiac troponin assays probably makes cardiac ischemia increasingly questionable as the true cause of a hospitalization for chest-pain symptoms without biochemical evidence of myocyte injury.

    “The advent of increasingly sensitive cardiac troponin assays probably makes cardiac ischemia increasingly questionable as the true cause of a hospitalization for chestpain symptoms without biochemical evidence of myocyte injury.27”

    From Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease (2017) · cites this paper as [27]

    The Conclusions (page unavailable) say that more sensitive troponin assays have reduced the proportion of patients classified as having unstable angina and that it is unclear whether acute coronary syndrome events occur without some troponin increase. That supports questioning an acute coronary syndrome diagnosis when sensitive testing shows no increase, but the paper does not extend that inference to cardiac ischemia as the cause of every chest-pain hospitalization; it also discusses angina without myocardial infarction. (LLM, conf=0.79)

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References 47 · Cited by 226

Research works printed but not linked: 40

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Authors
Braunwald, E., & Morrow, D. A.
Affiliations
  • From the TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA.
  • Brigham and Women's Hospital (US)
ORCID
Morrow, David A.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-06-18
Volume
127
Issue
24
Pages
2452-2457
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.113.001258
OpenAlex
W2167000122
Cited by
226
References
47
Citations by year
2026: 13 · 2025: 12 · 2024: 14 · 2023: 18 · 2022: 24 · 2021: 15 · 2020: 20 · 2019: 17 · 2018: 25 · 2017: 22 · 2016: 14 · 2015: 8 · 2014: 16 · 2013: 7
FWCI
2.43
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords
unstable angina, coronary artery disease, myocardial ischemia
MeSH terms
Angina, Unstable, Diagnosis, Differential, Electrocardiography, Humans, Myocardial Infarction, Necrosis, Troponin, Myocytes, Cardiac, Angina, Stable

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