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Infective Endocarditis After Transcatheter Aortic Valve Implantation: Results From a Large Multicenter Registry

Open access
Amat-Santos, Ignacio J., Messika-Zeitoun, David, Eltchaninoff, Helene, Kapadia, Samir, Lerakis, Stamatios, Cheema, Asim N., Gutiérrez-Ibanes, Enrique, Munoz-Garcia, Antonio J., Pan, Manuel, Webb, John G., Herrmann, Howard C., Kodali, Susheel, Nombela-Franco, Luis, Tamburino, Corrado, Jilaihawi, Hasan, Masson, Jean-Bernard, de Brito, Fabio Sandoli, Ferreira, Maria Cristina, Lima, Valter Correa, Mangione, José Armando, Iung, Bernard, Vahanian, Alec, Durand, Eric, Tuzcu, E. Murat, Hayek, Salim S., Angulo-Llanos, Rocio, Gómez-Doblas, Juan J., Castillo, Juan Carlos, Dvir, Danny, Leon, Martin B., Garcia, Eulogio, Cobiella, Javier, Vilacosta, Isidre, Barbanti, Marco, R. Makkar, Raj, Ribeiro, Henrique Barbosa, Urena, Marina, Dumont, Eric, Pibarot, Philippe, Lopez, Javier, Roman, Alberto San, Rodés-Cabau, Josep·2015·Circulation

Abstract

Background—: We aimed to determine the incidence, predictors, clinical characteristics, management, and outcomes of infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). Methods and Results—: This multicenter registry included 53 patients (mean age, 79±8 years; men, 57%) who suffered IE after TAVI of 7944 patients after a mean follow-up of 1.1±1.2 years (incidence, 0.67%, 0.50% within the first year after TAVI). Mean time from TAVI was 6 months (interquartile range, 1–14 months). Orotracheal intubation (hazard ratio, 3.87; 95% confidence interval, 1.55–9.64; P =0.004) and the self-expandable CoreValve system (hazard ratio, 3.12; 95% confidence interval, 1.37–7.14; P =0.007) were associated with IE (multivariate analysis including 3067 patients with individual data). The most frequent causal microorganisms were coagulase-negative staphylococci (24%), followed by Staphylococcus aureus (21%) and enterococci (21%). Vegetations were present in 77% of patients (transcatheter valve leaflets, 39%; stent frame, 17%; mitral valve, 21%). At least 1 complication of IE occurred in 87% of patients (heart failure in 68%). However, only 11% of patients underwent valve intervention (valve explantation and valve-in-valve procedure in 4 and 2 patients, respectively). The mortality rate in hospital was 47.2% and increased to 66% at the 1-year follow-up. IE complications such as heart failure ( P =0.037) and septic shock ( P =0.002) were associated with increased in-hospital mortality. Conclusions—: The incidence of IE at 1 year after TAVI was 0.50%, and the risk increased with the use of orotracheal intubation and a self-expandable valve system. Staphylococci and enterococci were the most common agents. Although most patients presented at least 1 complication of IE, valve intervention was performed in a minority of patients, and nearly half of the patients died during the hospitalization period.

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Metadata

Authors
Amat-Santos, I. J., Messika-Zeitoun, D., Eltchaninoff, H., Kapadia, S., Lerakis, S., Cheema, A. N., Gutiérrez-Ibanes, E., Munoz-Garcia, A. J., Pan, M., Webb, J. G., Herrmann, H. C., Kodali, S., Nombela-Franco, L., Tamburino, C., Jilaihawi, H., Masson, J.-B., de Brito, F. S., Ferreira, M. C., Lima, V. C., Mangione, J. A., Iung, B., Vahanian, A., Durand, E., Tuzcu, E. M., Hayek, S. S., Angulo-Llanos, R., Gómez-Doblas, J. J., Castillo, J. C., Dvir, D., Leon, M. B., Garcia, E., Cobiella, J., Vilacosta, I., Barbanti, M., R. Makkar, R., Ribeiro, H. B., Urena, M., Dumont, E., Pibarot, P., Lopez, J., Roman, A. S., & Rodés-Cabau, J.
Venue
Circulation
Published
2015-05-05
Volume
131
Issue
18
Pages
1566-1574
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2676575250
Cited by
280
References
4
FWCI
18.58
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Infective Endocarditis After Transcatheter Aortic Valve Implantation: Results From a Large Multicenter Registry. https://app.cochat.ai/papers/10.1161/circulationaha.114.014089
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Amat-Santos, I. J., Messika-Zeitoun, D., Eltchaninoff, H., Kapadia, S., Lerakis, S., Cheema, A. N., Gutiérrez-Ibanes, E., Munoz-Garcia, A. J., Pan, M., Webb, J. G., Herrmann, H. C., Kodali, S., Nombela-Franco, L., Tamburino, C., Jilaihawi, H., Masson, J.-B., de Brito, F. S., Ferreira, M. C., Lima, V. C., . . . Rodés-Cabau, J. (2015). Infective Endocarditis After Transcatheter Aortic Valve Implantation: Results From a Large Multicenter Registry. Circulation. https://doi.org/10.1161/circulationaha.114.014089

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.