The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy
Abstract
Vast parts of mammalian genomes encode for transcripts that are not further translated into proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained paradoxical for a long time. However, a growing body of evidence demonstrates that long noncoding RNAs are dynamically expressed in different cell types, diseases, or developmental stages to execute a wide variety of regulatory roles at virtually every step of gene expression and translation. Indeed, long noncoding RNAs influence gene expression via epigenetic modulations, through regulating alternative splicing, or by acting as molecular sponges. The abundance of long noncoding RNAs in the cardiovascular system indicates that they may be part of a complex regulatory network governing physiology and pathology of the heart. In this review, we discuss the multifaceted functions of long noncoding RNAs and highlight the current literature with an emphasis on cardiac development and disease. Furthermore, as the enormous spectrum of long noncoding RNAs potentially opens up new avenues for diagnosis and prevention of heart failure, we ultimately evaluate the futuristic prospects of long noncoding RNAs as biomarkers, and therapeutic targets for the treatment of cardiovascular disorders, as well.
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Cites
Yaşlı Kadınlarda Üreme Sağlığı
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Cited by
Peng, T., Liu, M., Hu, L., Guo, D., Wang, D., Qi, B., Ren, G., Hu, C., Zhang, F., Chun, H. J., et al. (2022) · Biology Direct · doi:10.1186/s13062-022-00346-6 · Cited by 57
Metadata
- Authors
- Bär, C., Chatterjee, S., & Thum, T.
- Venue
- Circulation
- Published
- 2016-11-08
- Volume
- 134
- Issue
- 19
- Pages
- 1484-1499
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2549388125
- Cited by
- 267
- References
- 110
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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