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Exercise Therapy and Cardiovascular Toxicity in Cancer
Open accessAbstract
Cardio-oncology is an emerging discipline focused predominantly on the detection and management of cancer treatment–induced cardiac dysfunction (cardiotoxicity), which predisposes to development of overt heart failure or coronary artery disease. The direct adverse consequences, as well as those secondary to anticancer therapeutics, extend beyond the heart, however, to affect the entire cardiovascular-skeletal muscle axis (ie, whole-organism cardiovascular toxicity). The global nature of impairment creates a strong rationale for treatment strategies that augment or preserve global cardiovascular reserve capacity. In noncancer clinical populations, exercise training is an established therapy to improve cardiovascular reserve capacity, leading to concomitant reductions in cardiovascular morbidity and its attendant symptoms. Here, we overview the tolerability and efficacy of exercise on cardiovascular toxicity in adult patients with cancer. We also propose a conceptual research framework to facilitate personalized risk assessment and the development of targeted exercise prescriptions to optimally prevent or manage cardiovascular toxicity after a cancer diagnosis.
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“during chemotherapy treatment there is a well-documented decline in cardiorespiratory fitness, as measured by VO2peak or 6-minute walk test(4).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [4]
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Metadata
- Authors
- Scott, J. M., Nilsen, T. S., Gupta, D., & Jones, L. W.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Norwegian School of Sport Sciences (NO)
- Venue
- Circulation
- Published
- 2018-03-13
- Volume
- 137
- Issue
- 11
- Pages
- 1176-1191
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC6028047
- OpenAlex
- W2793682287
- Cited by
- 239
- References
- 105
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 29 · 2023: 33 · 2022: 35 · 2021: 29 · 2020: 48 · 2019: 25 · 2018: 8
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- National Cancer Institute (P30CA008748)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- exercise therapy, cardio-oncology, cardiotoxicity, heart failure, coronary artery disease, cancer therapy, exercise prescription, individual risk assessment, cancer patients
- MeSH terms
- Antineoplastic Agents, Cardiovascular Diseases, Exercise Therapy, Health Status, Humans, Risk Factors, Treatment Outcome, Risk Assessment, Cardiotoxicity
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