Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus

Giugliano, Robert P.; Cannon, Christopher P.; Blazing, Michael A.; Nicolau, José C.; Corbalán, Ramón; Špinar, Jindřich; Park, Jeong-Gun; White, Jennifer A.; Bohula, Erin A.; Braunwald, Eugene

doi:10.1161/circulationaha.117.030950

Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus

Background: Ezetimibe, when added to simvastatin, reduces cardiovascular events after acute coronary syndrome. We explored outcomes stratified by diabetes mellitus (DM). Methods: In IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial), 18 144 patients after acute coro…