Cardiac Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 Diabetes Mellitus
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Patients with type 1 diabetes exhibit elevated levels of anti-heart autoantibodies.
“Sousa et al reported that patients with type 1 diabetes, an autoimmune condition, exhibit elevated levels of anti-heart autoantibodies”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [155]
In the study’s main text (page not provided), cardiac autoantibodies were detected in 146 of 892 participants with type 1 diabetes (16%). This supports their presence in some patients, but the paper reports antibody positivity, not elevated antibody levels relative to a comparison group. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn patients with type 1 diabetes, anti-heart autoantibody levels correlate with cardiac dysfunction and increased cardiovascular disease risk.
“which correlate with cardiac dysfunction and increased cardiovascular disease risk.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [155]
In the main text (page unavailable), the study associates positivity for ≥2 cardiac autoantibodies with larger left ventricular dimensions and lower ejection fraction in patients with type 1 diabetes; it does not establish a correlation across antibody levels. Its limitations state that too few heart-failure events occurred to assess risk, and the conclusion says future risk requires longer follow-up. The increased cardiovascular disease risk attributed to this study is therefore not supported. (LLM, conf=0.90)
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Cites
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans
Lv, H., Havari, E., Pinto, S., Gottumukkala, R. V. S. R. K., Cornivelli, L., Raddassi, K., Matsui, T., Rosenzweig, A., Bronson, R. T., Smith, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44583 · Cited by 228 · see citing works
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Research works printed but not linked: 4
- [1]Sousa GR, Pober D, Galderisi A, Lv H, Yu L, Pereira AC, Doria A, Kosiborod M, and Lipes MA. Glycemic control, cardiac autoimmunity, and long-term risk of cardiovascular disease in type 1 diabetes mellitus. Circulation. 2019; 139: 730– 743. 30586738 PMC6361693
- [2]Turkbey EB, Backlund JY, Genuth S, Jain A, Miao C, Cleary PA, Lachin JM, Nathan DM, van der Geest RJ, Soliman EZ, Liu CY, Lima JA, and Bluemke DA. Myocardial structure, function, and scar in patients with type 1 diabetes mellitus. Circulation. 2011; 124: 1737– 46. 21947298 PMC3215589
- [3]Genuth SM, Backlund JY, Bayless M, Bluemke DA, Cleary PA, Crandall J, Lachin JM, Lima JA, Miao C, Turkbey EB, and DCCT/EDIC Research Group. Effects of prior intensive versus conventional therapy and history of glycemia on cardiac function in type 1 diabetes in the DCCT/EDIC. Diabetes. 2013; 62: 3561– 9. 23520132 PMC3781466
- [5]Gottumukkala RV, Lv H, Cornivelli L, Wagers AJ, Kwong RY, Bronson R, Stewart GC, Schulze PC, Chutkow W, Wolpert HA, Lee RT, and Lipes MA. Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes. Sci Transl Med 2012; 4: 138ra80. PMC4303259 22700956
Cited by
Sorted by citations
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Sousa, G. R., Kosiborod, M., Bluemke, D. A., & Lipes, M. A.
- Affiliations
- Brigham and Women's Hospital (US)
- The George Institute for Global Health (AU)
- University of Wisconsin–Madison (US)
- Venue
- Circulation
- Published
- 2020-03-31
- Volume
- 141
- Issue
- 13
- Pages
- 1107-1109
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC7121734
- OpenAlex
- W3013239677
- Cited by
- 20
- References
- 1
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103609, R01DK103699, P30DK036836)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardiac autoimmunity, subclinical cardiac dysfunction, type 1 diabetes, autoantibodies, myocardial function
- MeSH terms
- Diabetes Mellitus, Type 1, Female, Heart, Humans, Male, Middle Aged, Autoimmunity, Diabetic Cardiomyopathies
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