PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36

Qi, Zhiyong; Hu, Liang; Zhang, Jianjun; Yang, Wenlong; Liu, Xin; Jia, Daile; Yao, Zhifeng; Chang, Lin; Pan, Guanxing; Zhong, Haoxuan; Luo, Xinping; Yao, Kang; Sun, Aijun; Qian, Juying; Ding, Zhongren; Ge, Junbo

doi:10.1161/circulationaha.120.046290

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36

Background: PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein cholesterol by degrading low-density lipoprotein receptor. Pleiotropic effects of PCSK9 beyond lipid metabolism have been shown. However,…