Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue

Li, Yanming; Ren, Pingping; Dawson, Ashley; Vasquez, Hernan G.; Ageedi, Waleed; Zhang, Chen; Luo, Wei; Chen, Rui; Li, Yumei; Kim, Sangbae; Lu, Hong S.; Cassis, Lisa A.; Coselli, Joseph S.; Daugherty, Alan; Shen, Ying H.; LeMaire, Scott A.

doi:10.1161/circulationaha.120.046528

Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue

Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life-threatening complications. To improve our understanding of ATAA pathogenesis, we aimed to comprehensively chara…