Coronary artery anomalies
Open accessAbstract
Coronary artery anomalies (CAAs) are a group of congenital conditions characterized by abnormal origin or course of any of the 3 main epicardial coronary arteries. Although CAAs have been identified as a common underlying condition in young athletes with sudden cardiac death, the widespread use of invasive and noninvasive coronary imaging has led to increased recognition of CAAs among adults. CAAS are often discovered as an incidental finding during the diagnostic workup for ischemic heart disease. The clinical correlates and prognostic implication of CAAs remain poorly understood in this context, and guideline-recommended therapeutic choices are supported by a low level of scientific evidence. Several studies have examined whether assessment of CAA-related myocardial ischemia can improve risk stratification in these patients, suggesting that multimodality imaging and functional tests may be key in the management of CAAs. The aim of this review is to outline definitions, classification, and epidemiology of the most relevant CAAs, highlighting recent advances and the potential impact of multimodality evaluation, and to discuss current therapeutic opportunities.
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There is no evidence that sudden cardiac death related to malignant anomalies such as origin from the opposite sinus is increased in TS.
“However, there is no evidence that sudden cardiac death related to malignant anomalies such as origin from the opposite sinus is increased in TS.397”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [397]
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References 104 · Cited by 281
- Authors
- Gentile, F., Castiglione, V., & De Caterina, R.
- Affiliations
- University of Pisa (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Cardiology Division, Pisa University Hospital, Italy (F.G., V.C., R.D.C.).
- Venue
- Circulation
- Published
- 2021-09-21
- Volume
- 144
- Issue
- 12
- Pages
- 983-996
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W3201304426
- Cited by
- 281
- References
- 104
- Citations by year
- 2026: 64 · 2025: 71 · 2024: 62 · 2023: 53 · 2022: 27 · 2021: 3
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- coronary artery anomalies, congenital coronary anomaly, sudden cardiac death in athletes, myocardial ischemia, risk stratification
- MeSH terms
- Coronary Artery Disease, Coronary Vessel Anomalies, Coronary Vessels, Echocardiography, Heart Defects, Congenital, Humans
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