Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Abdellatif, Mahmoud; Trummer-Herbst, Viktoria; Heberle, Alexander Martin; Humnig, Alina; Pendl, Tobias; Durand, Sylvère; Cerrato, Giulia; Hofer, Sebastian J.; Islam, Moydul; Voglhuber, Julia; Ramos Pittol, José Miguel; Kepp, Oliver; Hoefler, Gerald; Schmidt, Albrecht; Rainer, Peter P.; Scherr, Daniel; von Lewinski, Dirk; Bisping, Egbert; McMullen, Julie R.; Diwan, Abhinav; Eisenberg, Tobias; Madeo, Frank; Thedieck, Kathrin; Kroemer, Guido; Sedej, Simon

doi:10.1161/circulationaha.122.059863

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Background: The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial. Methods: We performed a lifelong study to ass…