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Cited by 390Cardiovascular Effects of ExerciseCardiomyopathy and Myosin StudiesCardiovascular and exercise physiology

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning

Pelliccia, Antonio, Maron, Barry J., De Luca, Rosanna, Di Paolo, Fernando M., Spataro, Antonio, Culasso, Franco·2002·Circulation
DOI 10.1161/hc0802.104534
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Abstract

Background The clinical significance and long-term consequences of left ventricular (LV) hypertrophy associated with intensive athletic conditioning remain unresolved. Methods and results We prospectively evaluated 40 elite male athletes who had shown marked LV cavity enlargement of > or = 60 mm, wall thickness of > or = 13 mm, or both in a longitudinal fashion with serial echocardiograms, initially at peak training (age 24 +/- 4 years) and subsequently after a long-term deconditioning period (1 to 13 years; mean, 5.6 +/- 3.8). After detraining, LV cavity dimension decreased by 7% (61.2 +/- 2.9 to 57.2 +/- 3.1 mm; P or = 60 mm) in 9 athletes (22%); in contrast, wall thickness returned to normal in each athlete. Multiple regression analysis demonstrated that approximately 50% of the incomplete reduction in cavity dimension was explained by increased body weight and recreational physical activity performed during the follow-up period. No athlete had developed cardiac symptoms, impaired exercise performance, or evidence of LV dysfunction. Conclusions LV remodeling was evident after long-term detraining, with significant reduction in cavity size and normalization of wall thickness. Resolution of cavity enlargement was, however, incomplete in most cases, and substantial chamber dilatation persisted in >20% of athletes. The possibility that this residual LV hypertrophy, apparently part of the athlete's heart syndrome, may have future long-term clinical implications in some individu…

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  1. 10.1161/circ.101.3.336 · DOI
  2. 10.1001/jama.1996.03540030045030 · DOI
  3. 10.1161/circ.91.5.1596 · DOI
  4. 10.1161/circ.62.5.7418156 · DOI
  5. 10.1161/circ.96.6.1863 · DOI
  6. Armitage P Berry G. Statistical Methods in Medical Research. Oxford England: McGraw-Hill; 1994: 277.

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Metadata

Authors
Pelliccia, A., Maron, B. J., De Luca, R., Di Paolo, F. M., Spataro, A., & Culasso, F.
Affiliations
  • Minneapolis Heart Institute Foundation (US)
  • From the Institute of Sports Science, Department of Medicine (A.P., R.D.L., F.M.D.P., A.S.), Rome, Italy; Minneapolis Heart Institute Foundation (B.J.M.), Minneapolis, Minn; and Department of Experimental Medicine, University La Sapienza (F.C.), Rome, Italy.
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-02-26
Volume
105
Issue
8
Pages
944-949
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/hc0802.104534
OpenAlex
W2009338965
Cited by
390
References
28
Citations by year
2026: 6 · 2025: 14 · 2024: 15 · 2023: 19 · 2022: 17 · 2021: 26 · 2020: 19 · 2019: 12 · 2018: 13 · 2017: 13 · 2016: 28 · 2015: 23 · 2014: 17 · 2013: 10 · 2012: 26
FWCI
5.47
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
Minneapolis Heart Institute Foundation
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
left ventricular hypertrophy, detraining, left ventricular remodeling, left ventricular wall thickness, elite athletes, body weight, leisure-time physical activity
MeSH terms
Adaptation, Physiological, Adult, Aging, Cardiac Volume, Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Diagnosis, Differential, Echocardiography, Electrocardiography, Heart Ventricles, Humans, Longitudinal Studies, Male, Physical Fitness, Rome, Sports, Stroke Volume, Time, Reproducibility of Results, Observer Variation, Ventricular Function, Hypertrophy, Left Ventricular, Cardiovascular Deconditioning

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