CoChat
Sign Up
Cited by 205Cardiac electrophysiology and arrhythmiasCardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Heart Failure After Myocardial Infarction: Altered Excitation-Contraction Coupling

Gómez, A.M., Guatimosim, S., Dilly, K.W., Vassort, G., Lederer, W.J.·2001·Circulation
DOI 10.1161/hc3201.092285
Open this paper in CoChat — free account

Abstract

Background — Heart failure (HF) frequently follows the occurrence of myocardial infarction (MI). Questions about how HF develops and what cellular defects contribute to this dysfunction led to this study. Methods and Results — MI was induced in rats by coronary artery ligation. Clinical examination of the post-MI (PMI) surviving animals indicated that they were in overt HF by all measures. Cellular examination of the cardiomyocytes by patch-clamp and confocal [Ca 2+ ] i imaging methods indicated that cellular function was significantly compromised. At the single-cell level, [Ca 2+ ] i transient amplitudes were reduced and contractions were decreased and slowed, although Ca 2+ current ( I Ca ) remained unchanged. The excitation-contraction coupling (ECC) gain function measured as Δ[Ca 2+ ] i / I Ca was significantly decreased. Ouabain, a cardiotonic steroid that blocks the Na + ,K + -ATPase and activates Ca 2+ entry via cardiac Na + channels, largely alleviated this defect. Conclusions — After MI, I Ca becomes less able to trigger release of Ca 2+ from the sarcoplasmic reticulum. This failure of ECC is a major factor contributing to the development of contractile dysfunction and HF in PMI animals. The improved ECC gain, enhanced Ca 2+ entry, and augmented Ca 2+ signaling due to cardiotonic steroids contribute to the beneficial effects of these agents.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/hc3201.092285

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. 10.1161/circ.99.8.1077 · DOI
  2. 10.1161/res.78.1.166 · DOI
  3. 10.1161/circ.101.22.2586 · DOI
  4. 10.1161/res.84.4.424 · DOI

Cited by

Sorted by citations

See all 205

Related

See all

Metadata

Authors
Gómez, A. M., Guatimosim, S., Dilly, K. W., Vassort, G., & Lederer, W. J.
Affiliations
  • From INSERM-U.390, IFR-3, Montpellier, France (A.M.G., G.V.), and Medical Biotechnology Center and School of Medicine, University of Maryland Biotechnology Institute, Baltimore (A.M.G., S.G., K.W.D., W.J.L.).
  • Inserm (FR)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-08-07
Volume
104
Issue
6
Pages
688-693
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/hc3201.092285
OpenAlex
W2096667649
Cited by
205
References
29
Citations by year
2026: 3 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 15 · 2012: 9
FWCI
9.99
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Institut National de la Santé et de la Recherche Médicale
  • Centre National de la Recherche Scientifique
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
heart failure, myocardial infarction, excitation-contraction coupling, calcium transients, sarcoplasmic reticulum calcium release, calcium current, cardiomyocyte contractile dysfunction, ouabain, cardiac glycosides, Na+/K+-ATPase, cardiac sodium channel, coronary artery ligation, rat model
MeSH terms
Animals, Calcium, Cardiotonic Agents, Heart Failure, Hypertrophy, Male, Membrane Potentials, Myocardial Contraction, Myocardial Infarction, Myocardium, Ouabain, Sarcoplasmic Reticulum, Tetrodotoxin, Calcium Channels, Survival Rate, Rats, Wistar, Calcium Signaling, Cell Size, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review