The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability
Open accessAbstract
Background Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown. Methods and Results In the present study, we examined stable and unstable human carotid atherosclerotic plaques retrieved by endarterectomy for the presence of IL-18 using reverse transcription-polymerase chain reaction (PCR), Western blot, and immunohistochemical techniques. IL-18 was highly expressed in the atherosclerotic plaques compared with control normal arteries and was localized mainly in plaque macrophages. IL-18 receptor was also upregulated in plaque macrophages and endothelial cells, suggesting potential biological effects. To examine the role of IL-18 in atherosclerosis, we determined the relation between IL-18 mRNA expression and signs of plaque instability using real-time quantitative PCR. Interestingly, significantly higher levels of IL-18 mRNA were found in symptomatic (unstable) plaques than asymptomatic (stable) plaques ( P <0.01). Conclusions These results suggest, for the first time, a major role for IL-18 in atherosclerotic plaque destabilization leading to acute ischemic syndromes.
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Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
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IL‐1, IL‐18, and IL‐33 families of cytokines
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New Markers of Inflammation and Endothelial Cell Activation: Part I
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Metadata
- Authors
- Mallat, Z., Corbaz, A., Scoazec, A., Besnard, S., Lesèche, G., Chvatchko, Y., & Tedgui, A.
- Venue
- Circulation
- Published
- 2001-10-02
- Volume
- 104
- Issue
- 14
- Pages
- 1598-1603
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2098444146
- Cited by
- 636
- References
- 4
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mallat, Z., Corbaz, A., Scoazec, A., Besnard, S., Lesèche, G., Chvatchko, Y., & Tedgui, A. (2001). Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability. Circulation. https://doi.org/10.1161/hc3901.096721
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