Blood Lipids and First-Ever Ischemic Stroke/Transient Ischemic Attack in the Bezafibrate Infarction Prevention (BIP) Registry: High Triglycerides Constitute an Independent Risk Factor
Abstract
Background — Despite unclear associations between blood lipids, including fractionated cholesterol and triglycerides, and stroke, recent evidence demonstrates that lipid-modifying agents decrease the risk of stroke in patients with coronary heart disease (CHD). Methods and Results — Patients with documented CHD who were screened for but not included in the Bezafibrate Infarction Prevention study and had no history of stroke or transient ischemic attack (TIA) (n=11 177) were followed up. At baseline, medical histories were obtained and blood lipids assessed at a central study laboratory. During a 6- to 8-year follow-up period, 941 patients were identified as having nonhemorrhagic cerebrovascular disease, of whom 487 had verified ischemic stroke (per clinical findings and brain CT) or TIA. Patients experiencing an ischemic stroke/TIA had higher mean levels of triglycerides, lower levels of HDL cholesterol, and lower percentages of cholesterol contained in the HDL cholesterol moiety (%HDL; P <0.01 for all). In a logistic regression model, the adjusted ORs for developing an ischemic stroke/TIA were 1.27 (95% CI 1.01 to 1.60) associated with triglycerides >200 mg/dL and 0.87 (95% CI 0.78 to 0.97) associated with a 5% decrease in %HDL. The increased risk associated with high triglycerides was found across subgroups of age, sex, patient characteristics, and cholesterol fractions. Conclusions — High triglycerides constitute an independent risk factor for ischemic stroke/TIA across subgroups of age, sex, patient characteristics, and cholesterol fractions, whereas high %HDL was an independent protective factor among patients with CHD. These findings support the role of blood lipids, including triglycerides, as important modifiable stroke risk factors.
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Increased concentrations of triglycerides and low HDL cholesterol are associated with non-haemorrhagic stroke.
“Increased concentrations of triglycerides and low HDL cholesterol are also associated with non-haemorrhagic stroke.490,491”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [490]
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References 34 · Cited by 158
Research works printed but not linked: 1
- Koren-Morag N, Tanne D, Graff E. et al. Cholesterol in low and high density lipoproteins and ischemic cerebrovascular disease: the Beza- fibrate Infarction Prevention (BIP) Registry. Arch Intern Med. In press.
- Authors
- Tanne, D., Koren-Morag, N., Graff, E., & Goldbourt, U.
- Affiliations
- From the Department of Neurology, Stroke Unit (D.T.), and Neufeld Cardiac Research Institute, Sheba Medical Center (U.G.), Tel Hashomer; Biochemical Laboratory, Ichilov Hospital, Tel Aviv Medical Center and Institute for Physiological Hygiene, Wolfson Medical Center, Holon (E.G.); and Division of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv (N.K., U.G.), Israel.
- Tel Aviv University (IL)
- Venue
- Circulation
- Published
- 2001-12-11
- Volume
- 104
- Issue
- 24
- Pages
- 2892-2897
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2158294316
- Cited by
- 158
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 9
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- ischemic stroke, transient ischemic attack, serum lipids, triglycerides, HDL cholesterol, cholesterol fractions, coronary artery disease, stroke risk factors, lipid-modifying drugs
- MeSH terms
- Age Factors, Aged, Hypolipidemic Agents, Bezafibrate, Ischemic Attack, Transient, Cerebrovascular Disorders, Coronary Disease, Female, Follow-Up Studies, Humans, Lipids, Male, Middle Aged, Registries, Risk Factors, Triglycerides, Multivariate Analysis, Logistic Models, Randomized Controlled Trials as Topic, Myocardial Ischemia
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