The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Differing Pattern of Sympathoexcitation in Normal-Weight and Obesity-Related Hypertension
Open accessAbstract
Hypertension in normal-weight and obese individuals is characterized by activation of the sympathetic nervous system. Measurement of spillover of the sympathetic transmitter, norepinephrine, to plasma indicates that the regional pattern of sympathetic activation in the 2 “variants” of essential hypertension differs, excluding the heart in obesity-related hypertension. Whether sympathetic nerve firing characteristics also differ is unknown. We studied multiunit and single fiber sympathetic nerve firing properties in patients with normal-weight hypertension and obesity-related hypertension, comparing these with nerve characteristics in normal-weight and obese people with normal blood pressure. Both normal-weight hypertensive (n=10) and obese hypertensive (n=14) patients had increased total multiunit muscle sympathetic nerve activity compared with the normal-weight (n=11) and obese (n=11) people with normal blood pressure (65±4 versus 47±6 bursts per 100 heartbeats, P <0.01 in the normal-weight groups and 68±4 versus 53±3 bursts per 100 beats, P <0.01 in the obese groups). Sympathetic activation in normal-weight hypertension was characterized by increased firing rate of single vasoconstrictor fibers (70±8 versus 28±3 spikes per 100 beats; P <0.001), increased firing probability per heartbeat (39±3% versus 20±3%; P <0.001), and higher incidence of multiple spikes per heartbeat (30±4% versus 17±4%; P <0.05). Sympathetic activation in obesity-related hypertension differed, involving recruitment of previously silent fibers, which fired at a normal rate. The pattern of sympathetic activation in normal-weight and obesity-related hypertension differs in terms of both the firing characteristics of individual sympathetic fibers and the sympathetic outflows involved. The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In lean hypertensive patients, the increase in sympathetic activity evident in multiunit burst number and size is because of an increase in the firing rate of individual single fibers, and to the common presence of firing salvos, multiple firings in a single cardiac cycle 31 (Figure 2).”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [31]
In the citing paper
“That multiunit sympathetic nerve firing is similarly increased in both lean and obese hypertensive patients is well known.31,32”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [31]
In the citing paper
“Conversely, with the coexistence of impaired norepinephrine reuptake with firing salvos in normal-weight essential hypertension 31,[33][34][35][36] and in depressive illness 42,51,79 and panic disorder, 51,79,80 there is evidence of cardiac risk, 84 even in panic disorder.[85][86][87]”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [31]
In the citing paper
“In obese hypertensive humans, there is enhanced muscle sympathetic nerve activity, but the neurophysiologic basis of this increase is different in obese vs lean hypertensive subjects67.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [67]
In the citing paper
“In lean hypertensive patients, the increased sympathetic activity is related to increased firing frequency of single nerve fibers.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [67]
In the citing paper
“In contrast, in obese normotensive and hypertensive subjects, the increased activity is due to recruitment of additional fibers and not to increasing firing frequency of single nerve fibers67.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [67]
In the citing paper
“The most likely is a prohypertensive contribution of increased muscle sympathetic nerve activity which is higher in hypertensive vs normotensive obese humans67.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measures of Reliability in Sports Medicine and Science
Hopkins, W. G. (2000) · Sports Medicine · doi:10.2165/00007256-200030010-00001 · Cited by 4,635
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642
Self-citationAnderson, E. A., Sinkey, C. A., Lawton, W. J., & Mark, A. L. (1989) · Hypertension · doi:10.1161/01.hyp.14.2.177 · Cited by 632
Sympathetic Activation in Obese Normotensive Subjects
Grassi, G., Seravalle, G., Cattaneo, B. M., Bolla, G. B., Lanfranchi, A., Colombo, M., Giannattasio, C., Brunani, A., Cavagnini, F., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.560 · Cited by 614
Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age
Sundlöf, G., & Wallin, B. G. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012170 · Cited by 601
Baroreflex Control of Sympathetic Nerve Activity in Essential and Secondary Hypertension
Grassi, G., Cattaneo, B. M., Seravalle, G., Lanfranchi, A., & Mancia, G. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.68 · Cited by 526
Sympathetic Activity in Obese Subjects With and Without Obstructive Sleep Apnea
Narkiewicz, K., van de Borne, P. J. H., Cooley, R. L., Dyken, M. E., & Somers, V. K. (1998) · Circulation · doi:10.1161/01.cir.98.8.772 · Cited by 525
Fasting, Feeding and Regulation of the Sympathetic Nervous System
Landsberg, L., & Young, J. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197806082982306 · Cited by 492
Relation Between Cardiac Sympathetic Activity and Hypertensive Left Ventricular Hypertrophy
Schlaich, M. P., Kaye, D. M., Lambert, E., Sommerville, M., Socratous, F., & Esler, M. D. (2003) · Circulation · doi:10.1161/01.cir.0000081775.72651.b6 · Cited by 459
Self-citationRegional Sympathetic Nervous Activity and Oxygen Consumption in Obese Normotensive Human Subjects
Vaz, M., Jennings, G., Turner, A., Cox, H., Lambert, G., & Esler, M. (1997) · Circulation · doi:10.1161/01.cir.96.10.3423 · Cited by 404
Self-citation
Cited by
Sorted by citations
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 696
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616
Self-citationThe human sympathetic nervous system: its relevance in hypertension and heart failure
Parati, G., & Esler, M. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs041 · Cited by 538
Self-citationTranslational medicine: the antihypertensive effect of renal denervation
DiBona, G. F., & Esler, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00647.2009 · Cited by 432
Self-citationShariq, O. A., & McKenzie, T. J. (2020) · Gland Surgery · doi:10.21037/gs.2019.12.03 · Cited by 427
Metadata
- Authors
- Lambert, E., Straznicky, N., Schlaich, M., Esler, M., Dawood, T., Hotchkin, E., & Lambert, G.
- Affiliations
- From the Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia.
- Baker Heart and Diabetes Institute (AU)
- Venue
- Hypertension
- Published
- 2007-11
- Volume
- 50
- Issue
- 5
- Pages
- 862-868
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2168053032
- Cited by
- 195
- References
- 41
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 17 · 2015: 14 · 2014: 12 · 2013: 11 · 2012: 13
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Australia
- Medical Research Council
- National Health and Medical Research Council (225108)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- obesity-related hypertension, sympathetic activation, muscle sympathetic nerve activity, norepinephrine spillover, firing probability, sympathetic outflow, essential hypertension
- MeSH terms
- Action Potentials, Adult, Aged, Blood Pressure, Electrocardiography, Electrophysiology, Female, Heart Rate, Humans, Hypertension, Male, Microelectrodes, Middle Aged, Obesity, Peroneal Nerve, Sympathetic Nervous System, Thinness, Sympathetic Fibers, Postganglionic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
